The relative contribution of somatomedin to the serum-stimulated growth of human fibroblasts.
Explore the source record for details and available documents.
Cell Division↗
Biomedical subjects
A Plet
Publications and source records attributed to A Plet.
Leprechaunism: studies of the relationship among hyperinsulinism, insulin resistance, and growth retardation.
Explore the source record for details and available documents.
Abnormalities, Multiple↗
Determination of human serum somatomedin activity in rabbit articular chondrocytes isolated and incubated in vitro-a critical study.
Explore the source record for details and available documents.
Adolescent↗
[Relationships between growth, and plasma growth hormone and growth factors under normal physiological conditions and during pathological states (author's transl)].
Growth hormone (GH) and somatomedin (Sm) are the main factors of human growth. Sm is GH-dependent, but Sm increase after hGH injection in hypopituitary dwarfs is slow, and preceded by a decrease. The liver and kidneys are the main places of Sm production in vivo, the liver having probably also a regulatory effect. In vitro, GH-dependent production of Sm may be obtained from fibroblasts as well as from liver cells. Sm activates thymidine uptake by cultured human fibroblasts and by activated human lymphocytes, this effect needing cofactors from serum. Discrepant correlations between growth, GH and Sm are found in some pathological situations, such as obesity, craniopharyngioma, celiac disease, infantile malnutrition. Moreover, transferrin, a plasma protein, correlates also with growth.
Dwarfism↗