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Biomedical subjects

A Pollock

Publications and source records attributed to A Pollock.

At least 37 records · Page 2Linked to original sources

Protection of cattle against heartwater in Botswana: comparative efficacy of different methods against natural and blood-derived challenges.

Five groups of Tswana-cross castrated male cattle between 20 and 30 months of age (a total of 158 animals) were transported from a ranch in a heartwater-free area of south Botswana to a feedlot near Gaborone in the east of Botswana where heartwater is endemic. On arrival, one group was vaccinated intravenously with the Onderstepoort sheep blood heartwater vaccine, one group was vaccinated intravenously with the new Onderstepoort tick-derived heartwater vaccine and a third group was vaccinated subcutaneously with this tick-derived vaccine. Vaccine reactions were blocked with long acting oxytetracycline on the first day of fever. A fourth group had a series of injections of long acting oxytetracycline on days 0, 7, 14 and 21 after arrival, and a fifth served as untreated controls. The animals remained at the feedlot for 65 days during which time they faced a low level of challenge by Amblyomma hebraeum ticks. None contracted heartwater and so they were then challenged, together with a further group of control cattle, with a dose of the sheep blood vaccine. Some animals in all groups had severe heartwater reactions and died despite therapy, but 76.7 per cent, 64.5 per cent and 74.3 per cent of the cattle in the blood vaccine, intravenous tick vaccine and long acting oxytetracycline groups respectively were resistant to challenge, compared with 48.3 per cent of the subcutaneous tick vaccine group and 36.4 per cent of the controls. It was concluded that intravenous vaccination of susceptible adult cattle with either the blood or the tick-derived vaccine needs careful monitoring in the month after vaccination and does not necessarily result in immune animals.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals

Therapy-related acute nonlymphocytic leukemia with inversion of chromosome 16 and a sustained remission.

Acute nonlymphocytic leukemia, apparently without a preleukemic phase, developed in a 48-year-old male who had received oral cyclophosphamide and razoxane in succession. Inversion of chromosome #16 was present in association with the morphologic features typically seen with this abnormality in de novo acute leukemia. Conventional chemotherapy resulted in complete remission, which lasted for 13 months. The importance of performing cytogenetic studies in cases of secondary leukemia is emphasized.

Acute Disease

Neutrophil FC-receptor expression in cells of the circulating and marginated pools.

A method for rosetting neutrophils was developed and optimal rosetting conditions determined. The adhesive properties of neutrophils and their ability to form rosettes were studied for cells in the circulating pool, and following exercise when the circulating pool had been enriched by neutrophils from the marginated pool. We found the marginated pool to be the same as the circulating pool in terms of rosetting subpopulations and the in vitro adhesive properties of these subpopulations, indicating that the two pools can be considered kinetically as one. We also showed that non-rosetting neutrophils can develop the ability to form rosettes following adhesion to glass in the presence of autologous serum.

Adolescent

Plastic ESR tubes: does static electricity affect the results?

Static electrical charges were applied to the inside and outside surfaces of plastic ESR tubes, and this had no demonstrable effect on the results of the test. A further study confirmed that the plastic apparatus gave identical results to the standard Westergren method using glass tubes.

Blood Sedimentation

Viral hepatitis.

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Hepatitis

The leukaemias.

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Bacterial Infections

The effect of cigarette smoking on blood sugar, serum insulin and non esterified fatty acids in diabetic and non diabetic subjects.

The effect of cigarette smoking on carbohydrate metabolism has been investigated in 10 diabetic and 18 non-diabetic subjects. All were habitual smokers. Neither the fasting plasma sugar nor the plasma sugar response to an oral glucose load was significantly altered by smoking. Serum insulin, free fatty acids, cholesterol and triglyceride were measured in 10 non-diabetic patients, and were not significantly altered by smoking. It is concluded that in habitual smokers at least, cigarette smoking does not impair carbohydrate metabolism. In addition, it seems that smoking before or during oral glucose tolerance test is unlikely to influence the diagnostic value of the test.

Adult