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Biomedical subjects

A Ponzone

Publications and source records attributed to A Ponzone.

At least 37 records · Page 2Linked to original sources
PubMed1977

Cellular and humoral factors involvement in the enhanced NBT reduction by neutrophil leucocytes of newborn infants.

The histochemical NBT test was performed on blood samples from ten healthy newborn infants. High spontaneous NBT reduction has been confirmed for neutrophils and assessed for monocytes. The stimulation of both neutrophils and monocytes with Escherichia coli endotoxin induces a statistically significant increase of NBT positive cells. The reason for the false positive test results in neonates was investigated by incubating neutrophils from adult donors and for different time periods in either neonatal or adult plasma before the addition of NBT. NBT reduction by adult neutrophils was increased after incubation in neonatal plasma, and this increase was related to the concentration of the plasma used. Maximum NBT reduction was observed after 90 min of incubation, at which time the NBT scores of adult cells incubated in neonatal plasma were similar to the results of tests performed on whole neonatal blood. It is concluded that neonatal leucocytes demonstrate efficient spontaneous and stimulated phagocytosis, and that there are, in the plasma of neonates, humoral factors which stimulated phagocytosis by neutrophils and are thus responsible for the false positive NBT test results observed in these subjects.

Endotoxins↗
PubMed1976

Casein phenotyping in witch's milk.

18 neonatal colostrum samples were analyzed by urea-starch-gel electrophoresis to determine their casein patterns. It was found that precise typing of both alpha-and beta-casein could be obtained after the secretory burst. This genetic marker can be employed at the family level.

Caseins↗
PubMed1976

Milk casein polymorphism in man.

Urea-starch-gel electrophoresis was used to examine 175 casein samples, 130 collected at random from women from the urban area of Turin, and 45 from women resident in villages in the Sardinian hinterland. Two polymorphic systems controlling alpha- and beta-casein were demonstrated in both groups, together with similar gene frequencies for individual alleles. In addition, a rare variant was discovered in the Sardinian group.

Caseins↗
PubMed1975

A new beta-chain variant in human milk.

Investigation on the genetic polymorphism of human casein at the population level resulted in the identification of a new variant within the beta-casein system. This discovery throws new light on the type of genetic control applicable to beta-casein.

Caseins↗
PubMed1975

Milk casein polymorphism in the Kikuyu population.

Urea-starch-gel electrophoresis of casein samples from women of the Kikuyu tribe (central Africa) shows that this Negroid population had the same alpha- and beta-casein polymorphic pattern as Caucasoids, though their gene frequencies for the beta-locus were inverted. A new beta-casein variant (named beta-E) was identified.

Black People↗