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Biomedical subjects

A Pottage

Publications and source records attributed to A Pottage.

28 records · Page 2Linked to original sources
PubMed1978

Fluorouracil cardiotoxicity.

Our of 140 patients treated with intravenous 5-fluorouracil, four developed ischaemic chest pain within 18 hours of either the second or third dose. In three of these patients the pain recurred after subsequent doses. Predose electrocardiograms in two cases were normal. None of the four patients had a history of ischaemic heart disease, although all had received left ventricular irradiation. Although cardiotoxicity is a rare complication of fluorouracil treatment, it merits wider recognition.

Adult↗
PubMed1977

Varicella myocarditis presenting with unusual ventricular arrhythmias.

A 10-year-old boy with varicella developed syncopal episodes caused by runs of self-terminating ventricular tachycardia and ventricular fibrillation. These arrhythmias were thought to be caused by varicella myocarditis and were resistant to most common antiarrhythmic agents. Continuous electrocardiographic recording and analysis proved extremely useful in the management of this case. Mexiletine, a new antiarrhythmic drug, was finally effective in controlling recurrent attacks of ventricular tachycardia.

Arrhythmias, Cardiac↗
PubMed1977

Drug-induced extrapyramidal signs in chronic liver disease--a case report.

Extrapyramidal effects of phenothiazines and related compounds are well documented and may be dose related. Impaired drug metabolism can occur in chronic liver disease. A case is reported of extra pyramidal signs occurring in a patient with alcoholic liver disease given the antiemetic Ancoloxin in therapeutic dosage.

Basal Ganglia Diseases↗
PubMedDate not supplied

Mexiletine in the prophylaxis of ventricular arrhythmias during acute myocardial infarction.

In a double-blind study involving 165 patients we examined the role of mexiletine, a new antiarrhythmic drug, for the prophylaxis of ventricular arrhythmias after acute myocardial infarction. Mexiletine or placebo was given orally to patients on arrival in the coronary care unit, and continuous electrocardiographic tape recordings were used to document arrhythmias. Ventricular tachycardia and R-on-T ventricular ectopic beats were significantly reduced in the mexiletine patients, but too few episodes of ventricular fibrillation occurred for statistical comment. When arrhythmias did occur in the mexiletine group, it was usually early in the study, at which time plasma drug levels were low. Adverse effects were uncommon. Patients who were given therapy, but in whom acute myocardial infarction could not be confirmed, suffered no serious consequences of taking mexiletine. The results demonstrate the benefit and limitations of prophylactic oral antiarrhythmic therapy for patients with acute myocardial infarction.

Acute Disease↗