PubMed Health⌕ Search

Biomedical subjects

A Pourany

Publications and source records attributed to A Pourany.

3 recordsLinked to original sources
PubMed1991

Effects of thiamine deficiency on the secretion of insulin and the metabolism of glucose in isolated rat pancreatic islets.

Isolated pancreatic islets from thiamine deficient rats secrete less insulin. The secretion of insulin in response to glucose and tolbutamide is also decreased in these islets. Glucose and pyruvate oxidations to CO2, were decreased in the islets isolated from thiamine deficient rats. In the islets from control but not from thiamine deficient rats the oxidations of glucose and pyruvate to CO2 were increased by tolbutamide. The results suggest that in thiamine deficiency the insulin secretion is impaired due to the decreased glucose oxidation.

Animals↗
PubMed1990

Effect of cyproheptadine on glucose tolerance, serum insulin and structure of pancreatic islets in rats.

The effect of cyproheptadine (CPH) on glucose tolerance, serum immunoreactive insulin (IRI) and structure of pancreatic islets in albino rats has been studied. Hyperglycemia with glucose intolerance was observed after 10 days of administration of CPH (40 mg/kg, ip). There was insignificant change of fasting IRI after the treatment. Histological studies indicated degranulation and vacuolation of beta cells with enlargement of capillaries. Improvement in blood glucose, glucose tolerance and structure of islets with proliferation of small pancreatic ducts and cell cords were observed 10 days after the withdrawal of CPH.

Animals↗