Biomedical subjects

A Pradignac

Publications and source records attributed to A Pradignac.

21 records · Page 2Linked to original sources

PubMed1991

Antispermatozoal autoantibodies and genital infection.

The aim of this study was to evaluate why high levels of antispermatozoa autoantibodies (SPZAA) in seminal fluid represent a particularly detrimental factor in male fertility. We studied a population of 219 patients consulting us on conjugal sterility associated with an initial asthenospermia. We looked in each case for the presence of SPZAA at the surface of spermatozoa in the seminal fluid and in the serum. We found 31 patients positive for surface SPZAA, 26 of whom had urogenital infections. We also demonstrated statistically significant correlations between high levels of SPZAA in seminal fluid and both a reduction in ejaculate volume and a tendency to oligospermia. A similar correlation was found between the reduction in ejaculate volume and oligospermia. These results suggest that urogenital infection is at present the main cause of SPZAA production, that testicular damage is frequently associated with apparently isolated glandular damage, and above all that a high level of SPZAA in seminal fluid has a more detrimental effect on male fertility due to more severe genital (glandular and testicular) damage.

Autoantibodies↗

PubMedDate not supplied

[Treatment and monitoring of primary hypothyroidism].

Treatment of primary hypothyroidism requires a long-term hormonal therapy with levothyroxine which restores a normal TSH value. In a series of 192 patients followed up for at least 3 years we tried to evaluate the variability of maintenance dosage and to analyse the factors predictive of replacement dosage. The L-T4 dosage varied from one individual to the other, from 0.6 to 3.2 micrograms/kg. The mean maintenance dosage (118 +/- 38 micrograms/day) was similar in men and women weight for weight, but it was higher in subjects aged under 60 and in those with Hashimoto's or congenital hypothyroidism. There is a positive linear relation between the equilibrium dose and the TSH value (n = 0.84; p < 0.001) and a negative relation with the L-T4 concentration (n = 0.71; p < 0.001). The yearly variation of dosage in each individual was small (about 3.5%) and of the same order as the variation of weight. We conclude that the L-T4 maintenance dosage depends on the cause of hypothyroidism, on the importance of biochemical abnormalities and on the patient's age, sex and weight. In practice, however, the necessary dosage is difficult to predict. In the equilibrium phase the need for replacements is remarkably stable. A yearly assay of baseline TSH seems to be sufficient to evaluate the quality of hormonal compensation in the absence of intercurrent events.

Adolescent↗

PubMedDate not supplied

Comparative study of semen in diabetic and healthy men.

This study examines the consequences of diabetes on male reproductive function. We have studied a group of 18 diabetics (15 type I, 3 type II) age 24 to 40 years (mean 34 +/- 5.3) with duration of diabetes from 2 to 30 years (mean 11.8 +/- 8.3). This group was compared to 20 semen donors. In diabetics higher sperm (p = 0.0063) and round cell (p = 0.031) concentrations/ml as well as a higher total spermatozoa count (p = 0.023) were observed. The percentage of abnormal sperms were also higher. None of the couples had consulted for sterility and they had a mean of 2 children. In this group of patients, diabetes was not a cause of subfertility. Specific spermiological alteration in diabetics might reflect a testicular damage secondary to their diabetes or disease.

Adult↗