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Biomedical subjects

A Prieto González

Publications and source records attributed to A Prieto González.

At least 19 recordsLinked to original sources

[Kidney lipomatosis in a transplantation donor].

OBJECTIVES: The aim of this clinical note is to report one case of incidental superficial renal mass during an organ explantation. METHODS: The renal donor was a 56-years-old male patient death for subaracnoidea haemorrhage without urological history. RESULTS: The anatomopathologic intraoperative study of the renal masses informed about the fatty nature of the tissue, and the renal implantation was performed. CONCLUSIONS: The find of a superficial renal mass during an organ explantatiation determine the necessity of a preoperative biopsy.

Humans↗

[Can PSA density predict the response to alpha-blockers in benign prostatic hyperplasia?].

INTRODUCTION AND OBJECTIVES: In BPH there is a growth of both glandular and stromal components. Most of adrenoceptors sites are in the fibromuscular stroma. So the higher is the stromal/epithelial ratio, the more effective will alpha-blockers be. There in an indirect way of stimating this ratio without performing a biopsy. Bearing in mind that PSA is produced by the prostatic epithelium, the lower PSA density (PSAd), the higher the stromal/epithelial ratio and the higher alpha-blocker activity. We pretend to study if PSAd is useful for predicting the response to alpha-blockers in BPH. MATERIAL AND METHODS: We studied 75 patients suffering from prostatism and diagnosed of bladder outlet obstruction secondary to BPH through IPSS symptom score, digital rectal examination, PSA, uroflowmetry, and transrectal ultrasound. All of them received Alfuzosin, 5 mg twice daily during 3 months, and then were evaluated again with IPSS and uroflowmetry. RESULTS: A statistically significant improvement was appreciated of the two studied parameters and in both groups of patient with regard to the pretreatment situation. A statistically significant better answer was also appreciated in the group of patient with smaller PSAd in comparison with the higher PSAd patients. CONCLUSIONS: Our results show that PDAd is usefu to estimate the stroma/epithelium ratio, and therefore the clinical response to alpha-blockers.

Adrenergic alpha-Antagonists↗

[Brucellar orchiepididymitis].

The brucellosis is an unusual entity whose incidence has diminished due to the improvement in preventive measures. We have carried out a retrospective study of all the patients admitted in our service between 1996 and 1998, with diagnosis of orchitis. Two of the 31 patients admitted for this reason presented a final diagnosis of brucellar orchiepididymitis. Both patients presented clinic of affectation from the general state accompanied by resistance to habitual antibiotic treatment. The patient's epidemic antecedents, accompanied by the suitable clinical evolution took to the suspicion of orchiepididymitis of brucellar etiology, with change in the antibiotic rule. The diagnosis of the process was obtained by means of serologic tests and blood cultures.

Adult↗

[Malignant neoplasms of the penis].

OBJECTIVE: To assess the behaviour and management of these uncommon neoplasias. MATERIAL AND METHODS: Between March 1975 and July 1999, a total of 95 malignant neoplasias of the penis were diagnosed and treated by our unit. Patients mean age was 62 years (28 to 87 years). A retrospective analysis of any associated lesions, biological behaviour of the various neoplasias, as well as therapies used is carried out. RESULTS: The squamous carcinoma of the penis (SCP) is the most frequent pathohistological entity entailing 78 cases (82%), followed by verrucous carcinoma (VC) 13 cases (13.5%), basal cells carcinoma 1 case, and melanoma, lymphoma and penile metastasis 1 case each. There is a significant presence of associated lesions with marked predominance of phimosis. The most frequent reason for the call is an injury of the penis (74 cases; 78%). Treatment was mainly partial penectomy (51 patients; 53.7%), followed by conservative treatment in 28 cases (30%). Inguinal lymphadenectomy was performed in 13 patients (14%), due to either a positive nodular biopsy or a persistent adenopathy following antibiotic therapy. CONCLUSIONS: Neoplasias showing superior biological behaviour are basal cell carcinoma of the penis, and verrucous carcinoma. Prognosis in SCP is based on pathological status and node involvement. Patients with pT1 tumours showed no metastatic adenopathies after follow-up regardless of cytological grading, and are therefore candidates to watchful waiting with regular monitoring. Melanoma of the penis is a highly aggressive tumour due to its high metastatic capacity with a poor prognosis.

Adult↗

[Basal cell carcinoma of the penis].

OBJECTIVE: To report an uncommon case of basal cell carcinoma of the penis. METHODS: A case of basal cell carcinoma of the penis is presented. This has been the only case of this tumor type detected in our setting. The literature is briefly reviewed. RESULTS/CONCLUSIONS: Basal cell carcinoma of the penis is rare. To date only 20 cases have been reported in the literature. To our knowledge, no case of distant metastasis has been documented. Diagnosis by gross examination may be difficult due to the broad polymorphism of this lesion and must be confirmed by histological analysis.

Basal Cell Carcinoma↗

[Management of obstructive uropathy in pregnancy].

INTRODUCTION: Obstructive uropathy in pregnant women is a relatively common condition. It can be difficult to assess due to the frequency with which physiologic dilation of the upper urinary tract is seen in pregnant women. PATIENTS AND METHOD: Over the past 3 years 40 pregnant women with symptomatic obstructive uropathy were seen in our service. RESULTS: Most pregnant women responded to conservative treatment (pain killers and antibiotics). In the remaining group, instrumentation was necessary through the urinary route: double J ureteral catheterism (10 patients: 6 due to uterine compression and 4 to lithiasis), percutaneous nephrostomy (4 patients: 2 due to ureteral catheter obstruction impossible to replace, and two due to urinary sepsis), or ureterorenoscopy (1 patient with lithiasis). CONCLUSIONS: The single most common cause for obstructive uropathy in our experience is ureteral compression due to a gravid uterus. Choice therapy in most cases is conservative treatment. When in spite of conservative treatment signs and symptoms persist, urinary by-pass with antibiotic prophylaxis must be performed. Ureterorenoscpy as a diagnostic and therapeutical approach should be taken into consideration in pregnant women with ureteral lithiasis. Incidence of pre-term labour was not higher than usual.

Adult↗

[Penile verrucous carcinoma].

OBJECTIVE: To report our experience with verrucous carcinoma of the penis. METHODS: Our series of penile carcinoma over the last 25 years were reviewed; 13 cases of verrucous carcinoma were found. The histological and clinical features, course and treatment of these patients are discussed and current literature reviewed. RESULTS: Of 95 cases of penile carcinoma diagnosed in our hospital, 13 were verrucous carcinoma of the penis (13.7%). Patient mean age was 64.7 years (range 33 to 93). The urethra was compromised in 2 (15.4%) and the corpora cavernosa in 4 (30.7%) patients. Five patients presented with inguinal lymphadenopathy. Treatment was by posthectomy in 3, resection of the glans penis in 2, partial penectomy in 6 and total penectomy in 2. One patient showed local recurrence at a mean follow-up of 7 years. No lymph node or distant metastasis from the primary penile tumor was observed. CONCLUSION: Verrucous carcinoma of the penis shows an aggressive behavior locally, but not biologically. Treatment continues to be by surgery. Patients undergoing surgery aimed at organ preservation should be carefully followed. In most of the patients, early diagnosis could have avoided more aggressive surgical techniques.

Adult↗

Renal vein thrombosis caused by laparoscopic cholecystectomy.

A 48-year-old woman was diagnosed with right renal vein thrombosis (RVT) 2 weeks after a laparoscopic cholecystectomy. The patient had none of the major risk factors for RVT or deep vein thrombosis. She was treated with long-term anticoagulation. Complete dissolution of the thrombi was reached 1 month after diagnosis.

Cholecystectomy↗

[Incidence and risk factors for calculi formation in patients treated with augmentation cystoplasty or intestinal substitution].

OBJECTIVE: Bladder stones have been observed more frequently in patients undergoing bladder augmentation or substitution than in the normal population. We analyzed the etiological factors influencing bladder stone formation in patients submitted to the foregoing procedures. METHODS: Between December 1986 and October 1994, 12 augmentation cystoplasties with detubularized ileum or colon (group I) and 24 substitution ileocystoplasties (group II) were performed. None of the patients were known to have urinary stone formation. The possible causes of bladder stone formation were analyzed in both patients groups. The patients were evaluated for urinary infection, post micturition bladder residue, urinary pH, and stone forming metabolic alterations in blood or urine. The latter consisted in determining the blood levels of creatinine, calcium, uric acid and phosphorus and the 24-hr urine levels of calcium uric acid, phosphorus, creatinine, urea, oxalic acidi citric acid and magnesium. The statistical analysis consisted of an unweighted logistic regression test and a chi square test between each of the above variables and the existence of bladder stones. RESULTS: In group I, 10 patients revealed recurrent urinary infections, 0 showed a significant post-micturition bladder residue, a pathologically alkaline pH was observed in 2 and the metabolic study of blood and urine revealed alterations in 9 patients. In group II, 18 patients revealed recurrent urinary infection, 13 patients had post-micturition bladder residue, a pathologically alkaline pH was observed in 1, and the metabolic study of blood and urine revealed alterations in 13 patients. The statistical analysis using the unweighted logistic regression test showed no significant relation between any of the parameters and the presence of stones, for the substitution group pr augmentation group. However, the chi-square test to determine the relation between the different varikables and the existence of stones, showed a statistically significant relation between an elevated urinary pH, recurrent urinary infection, post-micturition bladder residue and bladder stone formation for groups I. Concerning the type of suture employed, some degree of relation between the use of non-resorbable suture and stone formation was found, although it was not statistically significant. CONCLUSION: We can therefore conclude that urinary pH, recurrent urinary infection annd post-micturition bladder residue, and probably use of nonreabsorbable suture, are among the etiological factors that we should avoid and treat in order to prevent the formation of bladder stones in patients undergoing augmentation or substitution cystoplasty.

Adolescent↗

[Right varicocele as first manifestation of situs inversus].

Traditionally, right varicoceles have been considered a rare entity nearly always secondary to a neoplastic or retroperitoneal disease. There are other possible etiologies for right varicoceles such as the venous disease of the large veins and visceral malposition syndromes. This paper presents one case report of right varicocele as the only clinical sign of situs inversus. Revision of the literature and nomenclature of these syndromes.

Adult↗

[Ultrasonography and intravenous urography in the diagnosis of blunt renal trauma].

OBJECTIVE: To analyze the sensitivity of renal ultrasonography and intravenous urography in renal trauma. METHODS: An extensive analysis on the sensitivity of IVP and US in the assessment of renal trauma was conducted using CT, renal selective arteriography or surgical exploration as the gold standard tests of reference to validate the initial diagnosis. RESULTS: IVP and US are useful techniques because of their high sensitivity in the diagnosis of renal trauma. The sensitivity of US decreases as the severity of the trauma increases (75% for grade I, 88.9% for grade II, 73.3% for grade III and 0% for grade IV), while that of IVP remains high for all degrees of severity (100% for grade I, 92% for grade II, 100% for grade III and 100% for grade IV). CONCLUSIONS: IVP and US were found to be useful techniques because of their high sensitivity in the diagnosis of blunt renal trauma. The sensitivity of US decreases as the severity of the trauma increases, while that of IVP remains high for all degrees of severity.

Humans↗

[The clinical evaluation of kidney trauma: the practical indications for complementary examinations].

The aim of the present work is to try to know the clinical data that can provide directions on the attitude to take with patients who seek advise with a suspicion of renal traumatism, thus allowing to select those that may require complementary examination. This is a retrospective revision of 190 cases of renal trauma admitted in our hospital between 1971 and 1992. We rated 3 large syndrome groups based on the patient's major signs and symptoms. The first indication in 71 patients was haemorrhagic syndrome (shock or anaemia); 100 patients had microscopic or gross haematuria non-associated to anaemia; and 6 patients showed painful signs and symptoms. Existence of renal injury should be suspected in patients that came to the hospital with a background of trauma, microscopic or gross haematuria, shock with or without haematuria or intraabdominal lesions; the performance of complementary examinations is necessary in patients with evidence of gross haematuria, microscopic haematuria associated to shock or suspected associated extra-renal intra-abdominal lesions, or shock whether or not associated to haematuria.

Abdominal Pain↗

[Local anesthesia in inguinoscrotal pathology].

Surgery, requiring the use of general orotracheal anaesthesia, has been the traditional treatment for many inguino-scrotal conditions. Over a number of years a gradual implementation of an alternative procedure consisting in the adoption of locoregional anaesthetic techniques has taken place, allowing to shorten hospital stays with the subsequent benefit for both the society at large, due of lower costs, and the patient through avoidance of general orotracheal anaesthetics and a faster discharge and return home. Based on these premises, 54 procedures were performed (16 inguinal varicocelectomies, 6 transinguineal orchiectomies, 21 hydrocelectomies, 3 spermatic cord cyst removals, 6 orchidopexy and 2 orchiectomies in patients diagnosed with testicular torsion). Our results demonstrate that this is an excellent technique which allows a ruled surgical procedure well tolerated by the patient and which allows to perform surgery without need of hospital stay.

Adolescent↗

[Inguinal bladder hernia. Report of 4 cases].

Vesical hernias are, in general, a rare condition, except when they have an inguinal location. These are common, although their diagnosis is not so, and it is not infrequent that they are a chance finding of an inguinal herniorrhaphy procedure, during which relevant, but rare, complications have been described when the bladder has not been suitably identified. We present four cases of inguino-vesical hernia (three, massive hernia), and include a literature review.

Aged↗

[Thalamic abscess. A stereotaxically treatable lesion].

Solitary abscesses of the thalamus are an infrequent entity which carry serious problems with regard to treatment. We present a patient with an unknown septic focci who developed a right thalamic abscess due to Streptococcus constellatus and was treated by stereotaxic drainage for the suppuration and antibiotics. The patient was clinically and radiologically (CAT) controlled up until total cure of the lesion. Complications included dissemination of the infection to the meningeal space and a residual coreic picture controlled with tetrabenzine. The authors believe that evacuation by stereotaxic punction should be included among the therapeutic options available for deeply localized cerebral abscesses.

Abscess↗

Gallbladder cholesterolosis: an aetiological factor in acute pancreatitis of uncertain origin.

To investigate the possible relationship between gallbladder cholesterolosis and acute pancreatitis, we studied 3797 cholecystectomy specimens and found 55 cases of gallbladder cholesterolosis unassociated with biliary lithiasis. From the reviewed case notes, 27 of these patients presented with recurrent attacks of acute pancreatitis which disappeared after cholecystectomy (follow-up 65.1 months). A microscopic study revealed frank cholesterolosis in all cases with a pseudopolyp transformation of the mucosa, some polyps reaching a diameter of 2 mm. We postulate that the mechanism could be temporary impaction of cholesterolosis polyps at the sphincter of Oddi and suggest that patients with recurrent attacks of acute pancreatitis and negative aetiological investigation must be considered as at high risk of having gallbladder cholesterolosis and that they could benefit from cholecystectomy.

Acute Disease↗