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Biomedical subjects

A Prior

Publications and source records attributed to A Prior.

28 records · Page 2Linked to original sources
PubMed1987

Reduction of colonic motility by intravenous nicardipine in irritable bowel syndrome.

The effect of nicardipine, a new dihydropyridine calcium antagonist, on postprandial colonic motility was assessed in 10 patients with irritable bowel syndrome. Each patient was studied twice receiving intravenously either N saline or nicardipine after a 1000 calorie meal. In the control study there was a significant (p less than 0.01) postprandial increase in the contractile activity of the colon, reaching a peak at approximately 20 minutes. Intravenous nicardipine completely abolished the colonic response, with a significant reduction in the number (p less than 0.005) and amplitude (p less than 0.005) of contractions and of the motility index (p less than 0.025). These results support the need for further studies to evaluate the therapeutic role of nicardipine in the irritable bowel syndrome.

Adult↗
PubMed1987

Hypnotherapy in severe irritable bowel syndrome: further experience.

Fifteen patients with severe intractable irritable bowel syndrome previously reported as successfully treated with hypnotherapy, have now been followed up for a mean duration of 18 months. All patients remain in remission although two have experienced a single relapse overcome by an additional session of hypnotherapy. Experience with a further 35 patients is reported giving a total group of 50. This group was divided into classical cases, atypical cases and cases exhibiting significant psychopathology. The response rates were 95%, 43%, and 60% respectively. Patients over the age of 50 years responded very poorly (25%) whereas those below the age of 50 with classical irritable bowel syndrome exhibited a 100% response rate. This study confirms the successful effect of hypnotherapy in a larger series of patients with irritable bowel syndrome and defines some subgroup variations.

Adult↗
PubMed1986

What determines whether an elderly patient can use a metered dose inhaler correctly?

The metered dose inhaler (MDI) technique of 30 elderly patients (mean age 79.9 years) was assessed. Sixty per cent were competent, though only 10% had an ideal technique; 40% were incompetent. Inadequate timing of actuation and inhalation was the most frequent error made. Competence was significantly related to mental status questionnaire (MSQ) scores of 7/10 or more. Patients who were first prescribed an MDI in hospital were significantly more likely to be competent than those prescribed an MDI by the general practitioner. Competence was not related to age, underlying diagnosis or duration of MDI therapy. Elderly patients requiring MDI therapy should be carefully selected and properly instructed by the prescribing doctor.

Aerosols↗
PubMed1986

Cardiogenic shock without a critically raised left ventricular end diastolic pressure: management and outcome in eighteen patients.

Eighteen patients in whom shock developed after acute myocardial infarction are described. There was electrocardiographic evidence of acute inferior infarction in 11, of inferolateral infarction in three, and of anteroseptal infarction in four. In all cases the right atrial pressure was the same as or exceeded the end expiratory pulmonary artery wedge pressure. Plasma volume expansion of 100-2500 ml was needed to produce an optimum pulmonary artery wedge pressure. Eleven patients needed additional inotropic support with dopamine. Despite the absence of a critical increase in pulmonary artery wedge pressure, potential or actual hypoxia was almost always present. Six patients needed endotracheal intubation and mechanical ventilation because they had severe hypoxia that was unresponsive to supplemental inspired oxygen. Life threatening arrhythmias were also common (ventricular fibrillation in seven patients and complete heart block in four). Five patients died. All surviving patients are well and only one requires treatment for heart failure.

Aged↗
PubMed1986

Management of irritable bowel syndrome.

Few drugs are of proven efficacy in irritable bowel syndrome. Bulking agents probably relieve constipation, spasmolytics may alleviate pain and antidiarrhoeals help control urgency and diarrhoea. With a combination of reassurance and therapeutic intervention up to 75% of patients can be expected to improve. For the 25% who do not, alternative therapies such as stress management, psychotherapy or hypnotherapy may prove effective.

Antidepressive Agents↗
PubMed1986

Irritable bowel syndrome. Definitions and epidemiology.

Irritable bowel syndrome affects up to 20% of the population, is more common in females and is one of the commonest disorders dealt with by gastroenterologists. It is now recognised that the disorder is not confined to the colon and can give rise to a wide variety of different symptoms.

Colonic Diseases, Functional↗
PubMed1986

Familial Barrett's oesophagus?

Two sisters presenting with Barrett's oesophagus both at the age of 66, are described. The endoscopic appearances revealed striking similarities in terms of severity and extent of the lesion and the presence of a hiatus hernia. At oesophageal manometry low lower oesophageal sphincter pressures were recorded in each case. These observations raise the possibility that familial factors may influence the development of this condition, and likely mechanisms are discussed.

Aged↗
PubMed1977

The anion gap.

Explore the source record for details and available documents.

Aged↗
PubMedDate not supplied

A self-regulating device for continuous reinfusion of jejunostomy effluent.

The management of a patient with an enteric fistula producing a large volume of effluent is time-consuming and complicated. In patients requiring defunctioning procedures the eventual aim is restoration of intestinal continuity. Prior to surgery however it is prudent to ensure that the bowel distal to the stoma will cope with the sudden return to its normal role without diarrhoea or colic. This paper describes a simple, cheap, portable device which can be easily made. The device is closed, self-regulating and can be adjusted to patients' requirements.

Equipment Design↗