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Biomedical subjects

A Proietti

Publications and source records attributed to A Proietti.

At least 37 records · Page 2Linked to original sources
PubMed1986

Role of arachidonate metabolism on the in vitro release of luteinizing hormone and prolactin from the anterior pituitary gland: possible involvement of lipoxygenase pathway.

The aim of the present study was to evaluate whether arachidonic acid metabolism may play a role on luteinizing hormone (LH) and prolactin (PRL) release directly at the pituitary level. To this purpose, exogenous arachidonic acid, alone or in presence of inhibitors of cyclooxygenase (indomethacin:IND) and lipoxygenase pathways (nordihydroguaiaretic acid:NDGA), was added to perfused rat anterior pituitary cells. PGE, PGF alpha, LH and PRL levels present in the eluate were assayed with specific RIA methods. Both PGE and PGF alpha show a dose-related response after the addition of increasing doses of arachidonic acid. The addition of 0.05 mM arachidonic acid induces an increase of LH and PRL. The addition of IND to the perfusion medium highly potentiates the stimulatory effects induced by arachidonic acid on LH and PRL release. On the contrary, the addition to the medium of either NDGA or IND plus NDGA completely reverses the stimulatory action induced by arachidonic acid alone. The present results suggest that: adenohypophyseal cells are able to metabolize exogenous arachidonic acid; arachidonic acid induces an elevation in LH and PRL levels; lipoxygenase pathway metabolite(s) are likely involved in these activities, and the site of action of arachidonic acid is at the pituitary level.

Animals↗
PubMed1984

[Whole-body irradiation for bone marrow transplantation].

High dose total body irradiation is widely used in conditioning regimens to treat patients undergoing bone marrow transplantation. Radiation-related complications observed in 67 patients who received total body irradiation and their correlation with physiopathological mechanism of clinical manifestations are discussed. Interstitial pneumonitis occurred in 9 patients in our study (14%); the relationship between the incidence of interstitial pneumonitis and many factors such as irradiation treatment techniques, pre-graft chemotherapy, bone marrow malignant as well hereditary diseases, are discussed and related to a detailed literature review. Radiation techniques are different in leukemic and thalassemic patients.

Adolescent↗
PubMedDate not supplied

[Antibioticotherapy based on statistics in intensive therapy].

The authors present the epidemiological data concerning nosocomial infections in their Intensive Care Unit, and discuss an antibiotic strategy statistically oriented by these data. In their experience, treatment based on statistical criteria, brought to a reduction in antibiotic consumption with particular regard to broad-spectrum antibiotics, and to a decrease in individual budget.

Anti-Bacterial Agents↗
PubMedDate not supplied

[Nodular pulmonary lesions. Evaluation of the significance of the radiographic semeiotics correlated with the results of transbronchial fiberscopic pulmonary biopsy and transparietal needle aspiration].

The results obtained in 148 patients affected by nodular lung lesions have been evaluated. Transbronchial pulmonary biopsies (TBPB) and/or transthoracic fine needle biopsies (NB) have been performed. Diagnostic yield of the performed procedures was 61.5% for TBPB and 91.5% for NB. Radiographic findings and their incidence rates in benign and malignant nodular lung lesions have been considered. Accuracy rate of radiographic features, evaluated by discriminant analysis, was 77.4%. Radiographic appearance has been more related to NB (87.6%) than to TBPB (72.5%).

Adolescent↗
PubMedDate not supplied

[Cancer of the bladder. Results of radiotherapy after partial cystectomy].

The authors evaluate 374 patients treated by adjuvant radiotherapy after conservative surgery or radiotherapy alone for bladder carcinoma, from 1974 to 1982. The five year survival rate was 61, 39, 8 and 43 percent, respectively, for stages A (84 pts), B (154 pts), C (65 pts) and NOS (71 pts). Two homogeneous groups of patients staged B, treated by conservative surgery and adjuvant radiotherapy were evaluated: group I by "high" dose radiotherapy (TDF greater than 95), group II by "low" dose (TDF between 50 and 95); the five years survival rates were, respectively, 59% and 28% (P less than 0.05). It is discussed the value of treatment of the bladder carcinoma by high dose radiotherapy after conservative surgery.

Adenocarcinoma↗
PubMedDate not supplied

[Normal values of T3-index and of thyroxine (T4) (author's transl)].

The normal values of T3-index and of thyroxine (T4) have been evaluated comparing a binomial distribution to frequential curve of all the values obtained. The findings are: T3-index = 89 divided by 112; T4 = 3.7 divided by 15.3 microgram/100 cm3 of serum.

Humans↗