Biomedical subjects

A Put

Publications and source records attributed to A Put.

At least 19 recordsLinked to original sources

PubMed1990

[Micromorphology of dentine in rats with chronic exposure to ammonium fluoride].

Wistar rats were exposed chronically to ammonium fluoride in a toxicological chamber where the concentration of fluoride ions was 0.0016 mg/m3 of air. The exposure lasted 6 hours daily five times weekly. The animals were sacrificed after 3.6 and 9 months of the experiment. Histological preparations were made from upper incisors with surrounding tissues. Microscopic examination demonstrated striation of dentine in the teeth, of these animals, which was due to development of decalcification bands. This type of changes was observed also by other authors and it is regarded as a characteristic feature of dentine damage by fluorine compounds.

Ammonium Compounds↗

PubMed1989

Studies on the toxicology of fluorine compounds. I. Histological and histochemical investigations on the liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride.

The liver, heart, lungs, and stomach of rats exposed to hydrogen fluoride were studied. Histological examination showed partial liver necrosis and emphysema. Using histochemical methods the effect of fluorine ions was found in: a reduction of the activity of succinic and beta-hydroxybutyric dehydrogenases in the liver, heart muscle, superficial and glandular epithelium cells, and in lamina propria of the gastric mucosa; an increase in the activity of lactate dehydrogenase in liver cells; an increase in the activity of acid phosphatase in the liver, heart muscle, bronchus epithelium, bronchioli, and interalveolar septum cells; an increase in the activity of alkaline phosphatase in the liver, lungs, and heart muscle connective tissue, and in all gastric epithelium cells. The results obtained mainly point to the inhibition of oxidative metabolism by fluoride ions.

Animals↗

PubMed1989

[Effect of essential phospholipids (EPL) on the course of chronic poisoning with organic solvents in rats].

Male Wistar rats were exposed in toxicological camera to the mixture of organic solvents. Composition and concentrations of the mixture were similar to the conditions in the production hall. The influence of essential phospholipids (EPL) on changes in the liver caused by the organic solvents were studied. Animals were exposed for 6 months. Histochemical and histological evaluation was performed after 2 and 6 months. In the liver of intoxicated animals marked vacuolar degeneration and diminution of glycogen contents were observed. Simultaneously, the protective effect of EPL was noted. It was expressed by distinctly decreased vacuolar degeneration, probably corresponding to neutral fat in hepatocytes as well as by normalization of glycogen contents.

Animals↗

PubMed1989

[Morphologic evaluation of the effect of long-term administration of ammonium fluoride on the seminiferous epithelium and epididymis in the rat].

Male rats were subjected to 9-month-long exposure to ammonium fluoride. The performed evaluation covered the seminiferous epithelium and epididymis. The greatest changes in animals used in the experiment were observed in epididymis. A small number of spermatozoa were seen in the lumen of ductus epididymis, while in the epithelial cells there were increased phagocytic processes, providing a proof that injured reproductive cells were eliminated from the genital tract.

Air Pollutants↗

PubMed1988

[The influence of long-term utilization of some herbicides on oral cavity tissues of white rats].

Three mixtures of herbicides have been administered to white rats of Wistar strain by means of stomach tube. After 9 months of studies laboratory examinations were carried out in these animals namely analysis of urine, peripheral blood, bone marrow smears and segments of parotid glands and cheek's mucous membrane were uptaken to histopathological examinations. Morphological changes whose intensification didn't depend on the dose and type of preparation have been found in the glands. These changes were of non-specific character--similar changes were also present in the glands in rats in the course of poisoning by other toxic agents. Vacuolar changes whose intensification was increasing with the exposure time have been observed in the cells of mucous membrane epithelium.

Animals↗

PubMed1985