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Biomedical subjects

A Putz

Publications and source records attributed to A Putz.

14 recordsLinked to original sources

Quantitative EEG analysis during motor function and music perception in Tourette's syndrome.

Gilles de la Tourette's syndrome (TS) is a neurobehavioral disorder of childhood onset that is characterized by motor and vocal tics and associated behavioral disturbances including obsessive-compulsive symptoms. We performed 30 channel quantitative electroencephalograms (EEGs) on 13 Tourette patients and 26 controls and studied both resting and manumotor/music perception activation conditions. Resting EEGs did not show any differences between patients and controls, as known from the literature. However, during simple and complex hand movements, as well as music perception tasks, there were subtle differences predominantly in alpha frequency. They suggested reduced brain activation during motor tasks in frontal and central regions, and on music perception in temporal and parietal regions, respectively. These findings may add evidence to the functional neuroanatomy of Tourette syndrome, affecting more areas than disturbed motor circuits.

Adolescent

[Compulsive disorder and Gilles de la Tourette syndrome. On the differential diagnosis of organic and psychogenic compulsive symptoms].

A high prevalence of obsessions and compulsions is recognized in patients with Gilles-de-la-Tourette syndrome. Comparison of a group of patients with Gilles-de-la-Tourette syndrome with a group with obsessive-compulsive disorder, using the diagnostic criteria of the DSM-III-R, showed significantly higher scores in both groups of patients in the Hamburg obsessive-compulsive inventory (short version) than in a control group. When selected items from this Inventory were entered in a discriminant analysis, it was shown that there were specific differences in the obsessive-compulsive symptoms in the Gilles-de-la-Tourette syndrome compared to an obsessive-compulsive disorder. Eighty-eight percent of the patients were correctly classified with respect to their diagnosis with eight items of the Hamburg obsessive-compulsive inventory. This result leads to the conclusion that differential observation of the psychopathology of obsessions and compulsions can contribute to the differential diagnosis in obsessive-compulsive disorder and Gilles-de-la-Tourette syndrome, which is still underdiagnosed in Germany compared to epidemiological data in the USA. Moreover, the different psychopathology may reflect differences between a neurotic and an organic basis for obsessions and compulsions.

Adult

Blunted growth hormone response to clonidine in Gilles de la Tourette syndrome.

Noradrenergic mechanisms have been involved in the pathogenesis of Gilles de la Tourette Syndrome (GTS). Since the central alpha 2 adrenergic agonist clonidine is widely used as a therapeutic agent in GTS, the present study aimed at assessing whether GH release after clonidine, representing central alpha 2-adrenergic receptor sensitivity, was altered in GTS. After administration of 2 micrograms/kg body weight clonidine, the GH response was examined in nine drug-free, alcohol-abstinent GTS patients (eight men, one woman) and in nine age- and sex-matched abstinent healthy controls. A blunted response of GH release (< 5 ng/ml) was observed in seven patients and the area under the curve (AUC) of the GH-release was significantly reduced (p < .01) compared to controls. This finding indicates an involvement of the noradrenergic system in GTS.

Adult

[Laparoscopic appendectomy as a routine procedure].

At the Gynaecology Department of the Bethesda Hospital, 100 patients undergoing a laparoscopic appendectomy were recruited for a prospective study. The first ten patients received no antibiotic, the second ten were given a three-day course of cephazolin, the third ten were treated with a combination of sulbactam and ampicillin and the remaining 70 received cefuroxime. There were no significant differences between the four groups in the mean operating time, the intraoperative complication rate or in the degree of inflammation as classified by the histological examination. The reduced rate of postoperative complications defined as pyrexia > 38 degrees C, elevated WBC and peritoneal irritation for more than two days, showed the advantage of antibiotic prophylaxis with cefuroxime with respect to single parameters and overall complication rates. There were no intraoperative or severe postoperative complications.

Adolescent

[Clinical studies of the proper indication of inlay and crown therapy in lateral tooth areas].

187 students were examined an epidemiological study for their dental conditions and requirements with respect to preservation and prosthetics. The persons tested showed a DMF-T index of 11.6 and a DMF-S index of 24.2 in the lateral tooth area. In our opinion the clinical investigation revealed that the total number of caries cases will rise three-fold due to the above-average frequency of secondary caries cases as the filling size (or the number of filling surfaces) increases. The amount of single crown dentures found in the lateral tooth area with 0.1 crowns per person tested turned out to be fairly low. The actual need for a tooth-preserving therapy concept by crowning in preference to the concept of filling therapy amounts to the twelve-fold of the existing single crown dentures.

Adolescent

Cystectomy: the treatment of choice in patients with carcinoma in situ of the urinary bladder?

Patients (n = 46) with carcinoma in situ (Tis) of the urinary bladder were treated by intravesical chemotherapy. The complete remission rate was 75%. After a mean interval of 17 months recurrent tumours were diagnosed in 47%. Radical cystectomy with urethrectomy was performed in eight patients. Distal ureterectomy and uretercystoneostomy was done in six patients because of a distal ureteric tumour. Based on this group of 46 patients and the current literature, the following criteria are essential in indicating cystectomy: (1) micro-invasion; (2) persistent Tis after adequate intravesical treatment; (3) progressive tumour; (4) Tis of ureter and/or prostate; (5) tumour recurrence at more advanced stage.

Administration, Intravesical

Carcinoma in situ of the bladder extending into the seminal vesicles.

Involvement of the urethra or distal ureter in 30 to 50 per cent of the patients with carcinoma in situ of the bladder is well known. Carcinoma in situ of the bladder extending to the seminal vesicles rarely has been mentioned. We discuss 2 patients with extension of carcinoma in situ into the seminal vesicles and replacement of the normally present cylindroid mucosal lining. Carcinoma in situ of the ureter, bladder and prostatic ducts also was present in both patients.

Aged

Early surgery in the management of pediatric blunt renal trauma.

Of 40 children with major blunt renal injuries managed surgically 30 (75 per cent) could be followed up to 13 years postoperatively (mean 4.5 years). Measurements of renal size on sequential excretory urograms demonstrated normal growth of the traumatized kidney in all but 1 child. No hypertrophy of the contralateral kidney was noted in any child. Kidney length correlated with renal plasma flow calculated by sequential scintiscans (r equals 0.77). Hypertension was noted in 3 patients. Split renal vein renin studies and angiography showed that hypertension was caused by renal artery stenosis in 1 patient. Although we cannot draw any firm conclusions with regard to the optimal management of major blunt renal injuries, we present precise data that are valuable in comparison to other series of patients managed conservatively or surgically.

Adolescent

[Urethral prolapse. Case report].

The article reports on the case of a girl of 11 1/2 years of age who was referred to hospital with an urethral prolapse. The prolapsed urethral mucosa was excised and the wound closed by suturing.

Age Factors