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Biomedical subjects

A Pyne

Publications and source records attributed to A Pyne.

3 recordsLinked to original sources
PubMed1988

Antagonism of neuromuscular blockade. The cardiovascular effects in children of the combination of edrophonium and glycopyrronium.

Glycopyrronium 5 or 10 micrograms/kg was administered either simultaneously with, or 1 minute before, edrophonium 1 mg/kg in order to antagonise competitive neuromuscular blockade in 80 children. Both doses of glycopyrronium given before the edrophonium resulted in an initial significant (p less than 0.01) increase in heart rate. Heart rate decreased significantly (p less than 0.01) in all groups after the edrophonium was given, and only glycopyrronium 10 micrograms/kg administered before edrophonium prevented a substantial decrease below baseline. Initial heart rate responses to glycopyrronium or edrophonium are rapid, and measurements at intervals of 30 seconds may be necessary to record these changes.

Child↗
PubMed1984

Age differences in memory for movement.

Two experiments were conducted. The purpose of the first experiment was to determine whether memory deficits for movement occur with age. The 52 subjects for Experiment 1 were placed in four age groups: 18-32; 33-47; 48-62; and 63-77. Tests were administered to determine each subject's ability to encode and recall as many as 12 consecutive linear movement lists. When minimal memory requirements were imposed, there was no significant difference in the ability of the older and younger subjects to immediately recall movements. Older subjects, however, could not recall movements as well as younger subjects when greater memory demands were placed on them. Experiment 2 was conducted to determine why memory impairments occurred in older subjects. Organizational schemes were imposed on the subjects, but age differences were still apparent when greater memory requirements were essential or a larger memory capacity was demanded.

Adolescent↗