[Relations between structure and activity in local anesthetics. I. Amino-esters and amino-éthers].
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Biomedical subjects
Publications and source records attributed to A Quevauviller.
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In order to study the modifications in the activity on some CNS drugs by the experimental diabetes, the authors are proposing a model of alloxanic diabetes in the mouse. Diabetes is induced by administering pure alloxan to a well selected brand of mice. Biochemical and histological observations obtained on different vital organs are comparable with those obtained with spontaneously diabetic mice (stable and steady glycemia). This model is consequently a good way of assessing pharmacological comparison.
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Polyalthia oliveri leaf alkaloid, oliveroline, shows in Mice antiparkinsonian properties which decrease or disappear with the alkaloïds extracted from the bark of the trunk, oliveridine and oliverine. The latter alkaloid has an antihypertensive effect which is not found in oliveridine, only hypotensive by a relaxant close to papaverine action on vascular smooth muscles.
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DL50 of the total alkaloids of Xylopia quintasii is 850 mg/kg per os in the mice. Papaverine like properties are described.
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