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Biomedical subjects

A R Benedetto

Publications and source records attributed to A R Benedetto.

9 recordsLinked to original sources
PubMed1989

Population exposure from nuclear medicine procedures: measurement data.

In order to estimate the public radiation burden from nuclear medicine studies, a TLD chip in a sealed plastic bag was taped on the abdomen of patients who received 111In as chloride or oxine, 201T1 chloride, or one of four common 99mTc agents. The TLD chip was removed after 24 h. Additionally, abdominal skin surface exposure rate measurements were performed with an ionization chamber survey meter at various times (0 to about 60 h). There was superb correlation between TLD and integrated exposure rate measurements and between TLD and ionization chamber measurements and MIRD calculated doses. Scenarios postulated for exposure of co-workers and family members yielded doses between 7 muSv (0.7 mrem) and 20 muSv (2 mrem) for the selected radiopharmaceuticals. Calculations of the total population exposure from nuclear medicine procedures indicate the per capita dose (amortized over the entire population) is approximately 0.4 muSv (0.04 mrem), a negligible dose compared to natural background and total medical irradiation.

Body Burden↗
PubMed1986

Intravascular hemolytic transfusion reaction without detectable antibodies: A case report and review of literature.

A case of intravascular hemolytic transfusion reaction without detectable antibodies occurring in a 55-year-old male is reported. Specificity for the C antigen in the Rh system was demonstrated by technetium-99m red cell survival studies. A cell-mediated mechanism of hemolysis was suspected and investigated. Previously reported cases are reviewed and discussed. The entity of intravascular hemolytic transfusion reaction associated with minimal symptoms and no detectable antibodies deserves further investigation.

Antigens, Surface↗
PubMed1979

A mathematical index of uniformity (IOU) for sensitivity and resolution.

The authors define a mathematically precise index of uniformity (IOU) and show that the IOU is a convenient tool to quantitate uniformity of sensitivity and resolution response for any given area of interest on the detector face. They also show that the IOU is an appropriate factor for weighing the mean values of sensitivity and resolution for nonuniformity of response; these weighted sensitivity and resolution factors are used to derive a weighted figure of merit which takes into account, in a single parameter, the nonuniformities of response inherent in the determination of sensitivity and resolution.

Mathematics↗
PubMed1978

Blood clearance rates of technetium-99m albumin preparations: concise communication.

Technetium-labeled human serum albumin (HSA) is extensively used as a cardiac imaging agent. An evaluation of the blood-clearance rates of electrolytically reduced HSA (EHSA) and four stannous-reduced HSA (SnHSA) preparations was conducted in dogs, and was compared with that of radioiodinated HSA (IHSA). The EHSA was found to have a clearance rate only about 1.5 times that of IHSA, whereas the SnHSA agents were cleared at two to five times the rate of IHSA. Thus, EHSA has definite advantages over SnHSA preparations for the purposes of blood-volume determinations required in quantitative cardiac studies and for the reduction of extravascular background in the accurate delineation of cardiac boundaries.

Animals↗
PubMed1976

A simplified radiopharmaceutical accountability record-keeping system.

A comprehensive system has been developed to ensure that a patient receives the proper radiopharmaceutical dose and that records of accountability are conveniently maintained. A radiopharmacy assay/utilization record serves as the control document for source products and derived new products. Color-coded numbered labels are used to maintain accountability among source products, derived products, prescriptions, logbooks, and patient doses. These measures have proved effective in simplifying documentation, minimizing dose-administration errors, and providing for radiopharmaceutical accountability.

Humans↗
PubMed1975

Simplified method for determining the modulation transfer function for the scintillation camera.

The modulation transfer function (MTF) has long been accepted as an index of scintillation camera system resolution, but the technique necessary for the derivation of the MTF has discouraged its widespread acceptance because of its tedious and time-consuming nature. We have shown that the generation of LSFs for input into computer programs for MTF generation can be accomplished very easily and in short periods of time by using a simplified method. Establishment of the validity of this simplified procedure should contribute to more widespread utilization of the MTF in routine quality control programs as a check for crystal deterioration, electronic circuitry degradation, and/or collimator damage.

Radionuclide Imaging↗
PubMed1975

Calculation of an estimate of throxine-binding globulin capacity.

An estimate of the serum thyroxine-binding globulin (TBG) may be computed from determinations of serum thyroxine and triiodothyronine uptake. A general equation for this computation is presented and a computer program for the calculation of the estimating parameters is dicussed. With these methods, the regression equation for the calculated TBG and the observed TBG is the line of identity, and the correlation coefficients from determinations on data from two laboratories were +0.88 and +0.96. The calculated TBG may be used as a screening test for abnormalities of thryoxinebinding protein and as an aid in the proper interpretation of thyroid function studies.

Computers↗