PubMed Health⌕ Search

Biomedical subjects

A R Bhavsar

Publications and source records attributed to A R Bhavsar.

5 recordsLinked to original sources
PubMed1999

Safety of repeated intravitreous injections of antibiotics and dexamethasone.

PURPOSE: To determine the retinotoxicity of repeated intravitreous injections of vancomycin, ceftazidime, and dexamethasone in rabbit eyes. METHODS: Twenty pigmented New Zealand rabbits were divided into two groups. In Group 1, the right eyes received repeated intravitreous injections with vancomycin 0.3 mg, ceftazidime 0.7 mg, and dexamethasone sodium phosphate 0.13 mg at three consecutive 48-hour intervals. Group 2 right eyes received three times higher dose of the same intravitreous drugs as used in Group 1, repeated at the same frequency. All left eyes served as control eyes. Retinotoxicity was monitored by slit-lamp biomicroscopy, indirect ophthalmoscopy, electroretinography, and light and electron microscopy. RESULTS: No evidence of retinotoxicity was found in Group 1 eyes. Photopic A-waves were significantly elevated, and 30- and 50-Hz flicker fusion amplitudes were significantly depressed in Group 2 eyes. No changes were found by clinical or histopathologic examination in the retinas of either group. CONCLUSIONS: Three repeated intravitreous injections at 48-hour intervals of a combination of vancomycin, ceftazidime, and dexamethasone in rabbit eyes at dosages that approximate drug concentrations recommended for human endophthalmitis were nontoxic. Similar injections at three times higher doses resulted in mild electroretinogram changes.

Animals↗
PubMed1998

Simplified technique for suturing a temporary keratoprosthesis for pars plana vitrectomy.

PURPOSE: To describe an efficient technique for suturing a Landers wide-field temporary keratoprosthesis for intraocular surgery in an eye with an opaque cornea. METHODS: Two sutures were preplaced at partial thickness into corneal stroma parallel to the corneoscleral limbus. Suture ends were placed through corresponding holes in the keratoprosthesis and tied. RESULTS: The temporary keratoprosthesis was held firmly in place with two sutures and provided clear visualization for extensive intraocular surgery. CONCLUSION: The preplaced two-suture technique for securing a temporary keratoprosthesis to the globe decreased the time that the globe was open.

Cornea↗
PubMed1997

Intraorbital air simulating an intraocular foreign body.

PURPOSE: To present an ultrasonographic finding that simulated an intraocular foreign body after repair of a ruptured globe. METHOD: Case report. An ultrasonogram of a post-trauma eye was correlated with a computed tomographic scan. RESULTS: B-scan ultrasonography was performed on an eye after repair of a corneoscleral laceration. The ultrasonogram showed a highly reflective echo source suggestive of a foreign body; however, an orbital computed tomographic scan demonstrated that the lesion was intraorbital air. CONCLUSION: Although a highly reflective echo source in the presence of a ruptured globe may suggest a foreign body, the presence of orbital air should also be considered when interpreting ultrasonograms used in the preoperative and postoperative management of globe trauma.

Adult↗