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A R Chogle

Publications and source records attributed to A R Chogle.

34 records · Page 2Linked to original sources
PubMed1996

American Rheumatism Association 1958 and 1987 revised criteria for rheumatoid arthritis--how useful to the clinician.

The American Rheumatism Association (ARA) criteria for rheumatoid arthritis (RA) were evaluated in 52 newly referred consecutive, clinically diagnosed cases of RA. The 1958 and 1987 criteria were highly correlated (r = 0.795). By the 1958 criteria, 48 cases (92.3%) had classical/definite RA while 40 cases (76.9%) satisfied the 1987 criteria traditional format. By the 1987 classification tree 50 cases (96.2%) belonged to the first three RA subsets while 2 cases (3.8%) belonged to the non-RA subsets. Comparing the clinicians opinion of the outcome with the statistical modelling of variables based on ARA criteria, we conclude that the clinicians opinion of the outcome is reflected by a combination of morning stiffness duration, number of swollen joints, erosion score on hand radiographs and erythrocyte sedimentation rate. We conclude that evaluation of ARA 1958 and 1987 criteria in individual cases has both diagnostic and prognostic significance. We propose a short questionnaire based on ARA criteria, for use in hospital out patient clinic for diagnosis of RA.

Adult↗
PubMedDate not supplied

Efficacy of a 14-day primaquine regimen in preventing relapses in patients with Plasmodium vivax malaria in Mumbai, India.

We studied the antirelapse efficacy of a supervised 14-d 15 mg/d regimen of primaquine therapy (n = 131) compared with no antirelapse therapy (n = 142) in 273 patients with confirmed Plasmodium vivax malaria in Mumbai, India, between July 1998 and April 2000. There were 6/131 (4.6%) recurrences in patients given primaquine compared with 13/142 (9.2%) in those not given antirelapse therapy. In the 14-d primaquine group, polymerase chain reaction-single strand conformational polymorphism (PCR-SSCP) genotyping analysis of pre- and post-treatment blood samples was done for the 6 patients who had a recurrence of parasitaemia and the results gave a true relapse rate of 2.29% (3/131), 2 samples were classified as reinfections and 1 sample did not amplify. Our results indicate probable resistance to the 14-d regimen of primaquine for the first time in India and illustrate the need to (i) monitor patients given this regimen and (ii) carry out comparative studies between primaquine and new drugs such as tafenoquine and bulaquine for preventing relapses.

Adolescent↗