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Biomedical subjects

A R Føreland

Publications and source records attributed to A R Føreland.

6 recordsLinked to original sources

Personality structure in patients with winter depression, assessed in a depression-free state according to the five-factor model of personality.

BACKGROUND: Depressive disorders are often associated with abnormalities of personality. This has also been found in Seasonal Affective Disorder, Winter Depression type (W-SAD), although relatively few and small studies have been done on this disorder so far, and mainly in the depressed phase. The aim of this study was to explore the personality structure and its possible background and clinical correlates in a larger group of patients with W-SAD, assessed in a non-depressed state, in the Five-Factor (or "Big Five") model of personality paradigm. METHODS: 82 persons (87% of those asked) with diagnosed W-SAD, most of them originally self-referred, who had previously received light treatment at our unit, completed a Norwegian version of an inventory yielding the personality factors Agreeableness, Surgency, Conscientiousness, Emotional stability, and Openness to experience. RESULTS: Compared to a Norwegian reference group, the mean scores of the W-SAD patients were significantly lower on the factors agreeableness, surgency and emotional stability, and significantly higher on conscientiousness. However, very few patients had scores outside the reference range. The personality factors do not seem to be associated with the core physiological manifestations of winter depression, but rather with the psychic aspects, and are poor predictors of response to light treatment. LIMITATIONS: Some reservations should be made as to the generalisability of the findings to SAD patients in general. Thus, increased conscientiousness may reflect help-seeking behaviour. CONCLUSIONS: Personality structure does not seem to predict occurrence of physiological reactions to lack of adequate daylight in autumn/winter, and is a poor predictor of improvement after light treatment, but may predict the associated psychic symptomatology.

Adult↗

Can winter depression be prevented by Ginkgo biloba extract? A placebo-controlled trial.

OBJECTIVE: The aim was to test the hypothesis that the Ginkgo biloba extract PN246, in tablet form (brand name Bio-Biloba), may prevent the symptoms of winter depression (WD) in patients with seasonal affective disorder (SAD). METHOD: A total of 27 SAD patients were randomized to receive double-blind placebo or Bio-Biloba for 10 weeks or until they developed symptoms of WD, starting in a symptom-free phase about 1 month before expected WD symptoms. An extended Montgomery-Asberg Depression Rating Scale was completed before and immediately after termination of medication. The patients also self-rated some key symptoms on a visual analogue scale every 2 weeks during the trial. RESULTS: There were no significant differences between the treatment groups in the number of patients who developed treatment-requiring WD, or in the development of single key symptoms during the trial. CONCLUSION: We did not find that Ginkgo biloba was able to prevent the development of the symptoms of winter depression.

Adult↗

Direct assessment of improvement in winter depression with a visual analogue scale: high reliability and validity.

Reliability and validity of direct visual analogue scale (VAS) ratings of improvement were assessed in 162 patients with Seasonal Affective Disorder, Winter Depression type (W-SAD), after light treatment for 6 consecutive days. The patients were rated with the Montgomery-Asberg Depression Rating Scale (MADRS) and a scale for the 'atypical' symptoms hypersomnia, hyperphagia and carbohydrate craving (the ATYP scale) before and after treatment. After treatment the patients also self-rated their global improvement on a 10-cm VAS, with anchoring points of 'No improvement' and 'Complete improvement'. VAS ratings were repeated several times, with 1-4 weeks between assessments, in a follow-up period, always referring to improvement in relation to baseline, and accompanied by a statement whether there had been any change since the former VAS rating. Shortly after treatment there was a mean reduction of 59.8% on the MADRS and 57.1% on the ATYP score, and 58.4% improvement as measured by the VAS. VAS rating correlated highly with percentage reduction of MADRS scores (r=0.85) and somewhat less with reduction of ATYP scores (r=0.64). VAS ratings in the follow-up period showed an extremely high test-retest reliability (r=0.96) for two consecutive ratings between which the patient stated that there had been no definite change. The results support the use of VAS ratings for assessment of global improvement after light treatment in patients suffering from W-SAD; use in other kinds of depression and with other types of treatment remains to be explored.

Adult↗

Dawn simulation vs. lightbox treatment in winter depression: a comparative study.

Dawn simulation, with gradually increasing bedside light in the morning, has shown promising results as an alternative to bright light treatment for winter depression. To compare these treatments, 61 out-patients with winter depression (20-70 years of age, 80% women) were randomized to receive either lightbox treatment with 1500-2500 lux white light for 2 h in the morning for 6 days on an out-patient basis (n=34), or dawn simulation treatment in their homes, with 60 or 90 min of light augmentation time to 100-300 lux, for 2 weeks (n=27). Patients' ratings of improvement on a visual analogue scale (correlating strongly with percentage reduction in an extended Montgomery-Asberg Depression Rating Scale (MADRS) score) at the end of treatment showed a mean of 40.0% (SD 27.7%) in the dawn simulation group and 57.4% (SD 29.9%) in the lightbox group (P=0.02). The majority of the patients in both groups maintained their improvement during a 9-week follow-up. Age, sex, current major depression or current use of antidepressants did not predict outcome in either group. No serious side-effects were observed.

Adult↗

Winter depression with spring exacerbation: A frequent occurrence in women with seasonal affective disorder.

Winter depression (WD) usually starts in October/November and remits in February/March, but some experience a relatively short depressive exacerbation in spring. To further characterize this spring exacerbation (SE), 84 previously diagnosed WD patients rated in retrospect whether they had experienced SE after their otherwise typical WD in the years before receiving active treatment. Thirty-nine percent of the women and 12% of the men reported to have experienced SE many times or practically every year; another 28 and 29%, respectively, had experienced SE a few times. In general, the symptomatology during SE was about the same as during WD. Female patients who had experienced SE many times or practically every year were marginally older (p = 0.05) and had suffered many more previous WD episodes (p = 0.0005) than female patients having experienced SE only a few times or never.

Adult↗