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Biomedical subjects

A R Fahmy

Publications and source records attributed to A R Fahmy.

14 recordsLinked to original sources
PubMed1968

The inhibition of deoxyribonucleic acid nucleotidyltransferase by stilboestrol derivatives.

The inhibition by diethylstilboestrol of DNA nucleotidyltransferase isolated from calf thymus was studied. The inhibition exercised by diethylstilboestrol appears to obey competitive kinetics with respect to DNA primer. The activities of both replicative and terminal enzymes were affected to the same extent. There was no evidence of binding between DNA and diethylstilboestrol. A comparative study of the inhibitory effects of some stilboestrol derivatives is presented. The alkyl substitution in the alphaalpha'-positions seem to alter the inhibitory effect of these compounds: dimethylstilboestrol was more inhibitory than stilbene, and diethylstilboestrol was more inhibitory than dimethylstilboestrol. Hexoestrol, in which the alphaalpha'-ethylenic linkage is saturated, was the most effective inhibitor.

Animals↗
PubMedDate not supplied

Visualization of coronary artery fistula with transesophageal echocardiography.

Coronary artery fistulas are relatively uncommon and are usually initially suspected on auscultation of a continuous murmur. Long-term complications include congestive heart failure, endocarditis, ischemia, and atrial arrhythmias. The role of echocardiography in visualization and diagnosis of these fistulas is expanding. We report two cases in which transesophageal echocardiography was used to visualize and better define proximal coronary arteries and coronary artery fistulas.

Adult↗