Sally Clark--a lesson for us all.
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Diagnosis, Differential↗
Biomedical subjects
A R Forrest
Publications and source records attributed to A R Forrest.
A method for the rapid detection of the zopiclone degradation product 2-amino-5-chloropyridine.
Zopiclone (Zimovane) is a cyclopyrrolone compound which exhibits hypnotic and sedative effects while also exhibiting anticonvulsant and muscle relaxant activities. The detection and quantification of zopiclone is difficult. It has a high molecular weight compared to most other commonly used drugs, therapeutic levels are not high, and it is unstable in nucleophilic solvents. A degradation product of zopiclone, 2-amino-5-chloropyridine (ACP) together with a method for its detection using high-performance liquid chromatography with diode array detection has been described previously. An account is presented of a simple method for the detection of ACP using gas chromatography with mass selective detection (GC/MS) which will facilitate detection of zopiclone use as part of a routine screen.
Azabicyclo Compounds↗
A simple and rapid method for the estimation of quinine using reversed-phase high-performance liquid chromatography with UV detection.
A method for measurement of quinine by high-performance liquid chromatography with detection by absorbance at 240 nm is described. The method is sensitive and free from analytical interferences from other drugs, including the quinine diastereoisomer quinidine. Data obtained by analysis of serum from a patient who took a quinine overdose are reported, and the results are compared to those obtained with a spectrofluorometric method.
Adolescent↗
A rapidly fatal overdose with flecainide.
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Adolescent↗