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Biomedical subjects

A R Lea

Publications and source records attributed to A R Lea.

5 recordsLinked to original sources

Developments in near-patient testing.

Important technologies for near-patient testing include 'desk-top' analysers, kits and systems for continuous monitoring, with the possibility of advances through approaches to genetic testing. Near-patient testing is now used in physicians' office, hospital ward, home care and population screening applications. Analytical performance achieved by operators in these settings may frequently cause concern and has led to increased support for accreditation and educational measures. While near-patient testing has much potential to contribute to health care, hard evidence of benefit is sparse, and the costs of such testing to health care systems may be substantial. The place of this technology still requires critical evaluation, in the context of system performance and relevance to health care.

Cost-Benefit Analysis

Assessment of physicians' office pathology testing: organisational considerations.

In this paper we consider organizational and design aspects of an assessment of physicians' office pathology testing, and discuss difficulties in measuring the level of performance and effectiveness of such diagnostic services. A major consideration is the trade-off between compliance with a well-defined protocol, and use of the technology in a way which resembles normal operating practice.

Australia

A comparative study of BP and USP rotating basket dissolution apparatus.

The difference between BP and USP rotating basket dissolution apparatus was investigated by applying both methods to a range of commercial formulations and the NCDA Performance Standard II. No significant differences were obtained between the two sets of apparatus for the commercial tablets. However appreciable difference was observed with the NCDA calibrator.

Pharmacopoeias as Topic

Analysis of diethylstilbestrol and its impurities in tablets using reversed-phase high-performance liquid chromatography.

A high-performance liquid chromatographic (HPLC) method is described which is capable of resolving cis- and trans-diethylstilbestrol (DES), DES mono- and dimethyl ethers and 4,4'-dihydroxystilbene. The mobile phase and internal standard used stabilise the cis-trans DES isomer ratio, and the method is capable of quantitating both isomers in dosage forms without derivatisation. Recovery of DES from tablets is quantitative. Results of tablet analyses using this method are compared with those obtained with the official spectrophotometric procedure.

Chromatography, High Pressure Liquid