Cataract in chronic renal failure.
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Biomedical subjects
Publications and source records attributed to A R Musa.
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One hundred adult Sudanese patients who presented to Soba University Hospital (SUH) with established chronic renal failure (CRF) were studied to determine the aetiology. Thirty-eight had chronic glomerulonephritis, 12 renal calculi, nine diabetic renal disease, seven chronic pyelonephritis, five sequelae of acute renal failure (ARF), four renal vascular disease, three polycystic disease of the kidneys, and two obstructive uropathy. In 20 patients the aetiology was not determined because of late presentation to hospital. The results were compared with those of the developed countries, which differ greatly from Sudan in climate, diet, race, culture and social habits. The main differences were in the prevalence of renal calculi which, although being the second commonest cause of CRF in the Sudan, were rare in European countries. Also, diabetes mellitus was a much commoner cause of CRF in Sudan than Europe. Other aetiological factors were similar.
The effects of sorghum and wheat bran were compared and contrasted in a group of healthy Sudanese subjects. Ten medical students were studied while taking their normal diet, a diet of 20 g/day of sorghum bran and a diet of 20 g/day of wheat bran, each for 3 wk. Toward the end of each dietary period the wet stool weight, gut transit time, and frequency of bowel evacuation were estimated. The mean stool weight on normal diet was 136.6 +/- 43.1 g/day, on sorghum bran 173.3 +/- 48.4 g/day, and on wheat bran 219.1 +/- 98.3 g/day. The increase produced by wheat bran was significant, p less than 0.001. Both brans produced a similar number of bowel evacuations. The results suggest that sorghum bran, which is both cheap and readily available in the Sudan, produces a similar number of bowel evacuations to those of wheat bran without significantly affecting stool weight or transit time.
The morphology of 68 renal biopsies from the Sudan is analysed. Schistosomal infection was more common among the nephrotic patients than in the average population (32% against less than 1%). In the schistosomal group the high incidence of focal sclerosing glomerulonephritis (28%) and of secondary amyloidosis (38%) was remarkable. The history is described of a boy in whom repeated biopsies showed the decrease of glomerular amyloid depositions accompanied by mesangial cell proliferation following treatment for schistosomiasis.
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