Biomedical subjects
Publications and source records attributed to A R Siam.
In chronic tophaceous gout, tophi may occur in various tissues of the body. The joints are one of the main tissues of the tophaceous deposits. The articular surface may be coated by heavy deposits. We present a case of a patient with chronic tophaceous gout where the tophaceous deposits formed an intra-articular mass causing symptoms of a loose body.
Calcium pyrophosphate dihydrate (CPPD) crystal deposition disease is conventionally classified into cases that are hereditary, idiopathic (sporadic) or associated with other disorders. In the idiopathic form, the disease usually occurs in middle-aged or elderly patients. An earlier age of disease onset is observed in the hereditary form and the form associated with other disorders. Therefore, the occurrence of CPPD crystal deposition disease in a young patient merits thorough investigation for an underlying cause such as haemochromatosis, hyperparathyroidism, Wilson's disease, hypophosphatasia or hypomagnesaemia and requires a family study to investigate a possible hereditary cause. We report a case of a young female patient who presented with pseudogout at the age of 24 years; no associated diseases or familial occurrence were found despite a follow-up of more than 12 years.
We describe a patient with abdominal pain and ascites, mesenteric lymphadenitis and peritoneal panniculitis. Initially her ANA was negative. The abdominal pain recurred again three years later and in between the two episodes she had had skin rash, alopecia, arthralgia, and positive Coombs' test-haemolytic anaemia. Her ANA became positive a few years after the initial episode.
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OBJECTIVES: To report two patients who developed reactive arthritis in association with Staphylococcus aureus infection. METHODS: A review of the case notes of two patients. RESULTS: Two adult female patients have developed sterile arthritis in association with Staph aureus infection. The first patient has had two episodes of arthritis; the first followed olecranon bursitis, the second followed infection of a central venous catheter used for dialysis. The second patient developed sterile arthritis while being treated for pyomyositis. Both patients had a self limited arthritis and were HLA-B27 negative. CONCLUSION: Reactive arthritis may rarely follow Staph aureus infection. HLA-B27 negativity may be associated with a self limited arthritis in these cases.
Dissection and rupture of popliteal cysts occur commonly. We describe a case of a 13-year-old girl with polyarticular juvenile rheumatoid arthritis who presented with anterior tibial swelling and dropped foot. She was found to have dissecting popliteal cyst resulting in anterior compartment syndrome.
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We describe here a 14-year old male patient with a life-long history of deformities of hands and feet, swelling of both knees and both wrists and limited motion of hips and elbows. His paternal aunt has similar findings. A two-month-old brother developed flexion deformities of the hands similar to those of the patients.
We describe our experience in handling six cases of pyogenic sacroiliitis. Two were males and four were females with a mean age of 24.9 years. None had a history of i.v. drug abuse. Blood cultures were positive in half of the patients. The sacroiliac joint aspirate was positive in one additional patient. Staphylococcus aureus was recovered from three of four culture positive cases. Bone and CT scans revealed abnormalities in all patients. Response to antibiotic therapy was satisfactory in all except one patient who had an early relapse. Early diagnoses and proper treatment would result in improved outcomes.
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A man with longstanding systemic lupus erythematosus who developed anterior dislocation of both shoulder joints is described. He also had typical Jaccoud's deformities of his hands and feet.
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