Plasma 6-keto-PGF1 alpha in acute myocardial infarction.
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Biomedical subjects
Publications and source records attributed to A Raineri.
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In a group of 31 healthy subjects submitted to the exercise test and subdivided according to the presence or absence of hypertensive reaction we have evaluated at rest, at the maximum of the exercise and at recovery the hemodynamic and metabolic parameters and the hemorheological determinants. From the obtained results it is evident that the hemorheological determinants in the two groups of subjects show an almost similar behavior and, in any case, they behave in a manner that the hemorheological pattern cannot be considered sufficient by itself for clarifying the physiopathological mechanism of the hypertensive reaction.
4 months of supervised physical training carried out by 70 male postinfarction patients resulted in a 30% statistically significant increase in the total work load achieved, an increased VO2 and O2 pulse, with an equally significant double-product (DP) decrease. Follow-up ergometric tests performed by 35 patients 24 months after rehabilitation exhibited DP comparable to those found at the end of the program. R wave change during exercise ECG, ejection fraction detected by a nuclear probe, echocardiographic assessment of left ventricular performance were compared with training results. The CPI and IPAT tests were used for psychological evaluation. After rehabilitation, the 50% Sten score drop shows that the patients reached almost normal anxiety levels.
The haemorheological determinants were studied in 83 patients with acute myocardial infarction (AMI); the survivors were subdivided in relation to diabetes and haemodynamic class. All viscosity determinants were measured at the early stage (within 48 hours) and in the two weeks after AMI. The haemorheological changes that are more evident in MI patients deceased, are not dependent on diabetes and haemodynamic class, except for the haematocrit, in MI patients survivors. The authors suggest that the blood rheology should form part of the parameters studied at the different stages of AMI. The also hold, according to indications reported by other authors, that the correction of their alterations is useful.
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