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Biomedical subjects

A Rasmussen

Publications and source records attributed to A Rasmussen.

At least 109 records · Page 6Linked to original sources
PubMed1985

Reduced tubular reabsorption of phosphate during post-operative glucose infusions in humans.

It is well-known that serum phosphate concentration decreases considerably during post-operative glucose infusions. The purpose of this study was to elucidate whether the renal handling of phosphate could be responsible for this fall. Twelve patients were studied during glucose and saline infusions on the 2 first post-operative days. The maximal tubular capacity for reabsorption of phosphate per litre of glomerulus filtrate (TmP/GFR) was significantly reduced during glucose infusions in relation to saline infusions. The glucose induced fall in serum phosphate concentration was correlated to the change in TmP/GFR (r2 = 0.71). This study did not explain the reduced TmP/GFR during the glucose infusions, but a high correlation was found between TmP/GFR and the changes in plasma glucose concentration during the infusions (r = -0.91).

Calcium↗
PubMed1985

Postoperative myocardial performance during glucose-induced hypophosphatemia.

Long-lasting hypophosphatemia was previously found to diminish myocardial performance. The present study aimed to elucidate if postoperative glucose-induced hypophosphatemia is of importance for myocardial performance. Sixteen patients undergoing elective colonic or rectal surgery were given 100 g glucose intravenously (as 20% glucose solution) on the first and second postoperative days. The infusion rate was 0.3 g/kg/hour. On both days the glucose infusion caused significant fall in P-phosphate (0.94 to 0.67 and 0.71 to 0.47 mmol/l, respectively). No changes were seen in P-calcium, P-potassium or P-sodium. Measurements of stroke volume and frequency, central venous pressure and mean arterial pressure were made immediately before and after the glucose infusions. Stroke volume and cardiac output were unaffected during the infusions, and also from the first to the second postoperative day. As the preload (central venous pressure) and the afterload (arterial pressure) similarly were unchanged by the glucose infusion, glucose-induced hypophosphatemia following elective surgery was judged to lack importance for the myocardial performance.

Aged↗
PubMed1985

Hypophosphatemia during postoperative glucose infusion.

The study was undertaken to elucidate if hemodilution is a cause of the fall in serum concentration of inorganic phosphate during postoperative infusion of glucose, and if the fall in serum phosphate is related to the tonicity of the solutions and/or the rate of infusion. The study comprised 48 patients in five subgroups. Hemodilution was clearly demonstrated not to be responsible for any of the fall in serum phosphate. The size of this fall was independent of whether the administered solution was isotonic or hypertonic. Reducing the infusion rate from 0.30 to 0.15 g glucose/kg/hour did not reduce the fall in serum phosphate. It was therefore concluded that whenever glucose solutions are administered in the postoperative period, a fall in serum phosphate of c. 0.25-0.35 mmol/l is to be expected.

Aged↗
PubMed1984

Azathioprine as single drug in the treatment of rheumatoid arthritis induces complete suppression of natural killer cell activity.

Natural killer (NK) activity against K 562 target cells was studied in 60 patients with definite or classic rheumatoid arthritis (RA), grouped by medication into 1) Controls not in remission-inducing therapy, 2) Patients treated with penicillamine, and 3) Patients treated with azathioprine. NK activity was found to be completely suppressed in the azathioprine group as compared with the controls (3.2 +/- 4.2% versus 35.9 +/- 14.8% specific lysis; p less than 0.01) except for one patient who received incomplete azathioprine treatment. The NK activity was not suppressed in the penicillamine group.

Arthritis, Rheumatoid↗
PubMed1984

Methylprednisolone pulse therapy induced fall in natural killer cell activity in rheumatoid arthritis.

Natural killer (NK) cell activity was studied in 8 patients with classic or definite rheumatoid arthritis (RA) by investigating the killing of K 562 cells by peripheral blood lymphocytes before, during, and after intravenous methylprednisolone pulse therapy (MPPT). MPPT produced a considerable fall in NK activity and after 3 months NK activity was less than half that before MPPT.

Adult↗
PubMed1984

Characteristics of resistance vessels in pre-eclampsia and normotensive pregnancy.

Isolated omental resistance vessels from women with pre-eclampsia had an increased media thickness/lumen diameter ratio compared to similar vessels from normotensive pregnant women. The active and passive tension length curves for the two groups of vessels were similar and like the classical tension length curve for skeletal muscles. The maximal media stress (force per media cross-section) was also similar; however, calculating in terms of equivalent pressure (on basis of Laplaces law) indicated that the vessels in vivo would have been able to contract against an increased blood pressure. The results indicate that pre-eclampsia is associated with structural alterations of the resistance vessels which might be of importance for the haemodynamics of pre-eclampsia.

Arteries↗
PubMed1983

Effect of cervical application of prostaglandin (PG) E2 on plasma 13,14-dihydro-15-keto-PGF2 alpha and oxytocin in pregnant women at term.

The concentrations of 13,14-dihydro-15-keto-prostaglandin F2 alpha (PGFM) and oxytocin were measured by radioimmunoassay in the peripheral plasma of 21 women with low Bishop scores in whom cervical ripening and labour were induced with a cervical cap containing 1.5 mg of prostaglandin (PG) E2, left in place for 6 h. Blood samples were taken before and at 3, 6, 9 and 24 h after the cap was applied. Four women (control group) had a cap without PGE2. Labour began in 13 women receiving PGE2, 12 of whom were delivered within 24 h. In these women plasma PGFM rose progressively to levels seen during spontaneous labour, paralleling the changes in cervical dilatation. The increase became significant at 6 h, when cervical dilatation was 4.5 cm (SEM 0.5). Plasma oxytocin also increased significantly while the cap was in place and then decreased. Plasma PGFM and oxytocin did not change in the control subjects, and in the eight women needing further induction of labour the initial rises were transient and not statistically significant.

Cervix Uteri↗
PubMed1982

General and local toxicity of 5-hydroxymethyl-2-furfural in rabbits.

General toxicity (A) and vein damaging properties (B) of 5-hydroxymethyl-2-furfural (HMF) were studied in rabbits. A. 400 mg HMF was given as subcutaneous injections twice a day for a week. It was not possible to demonstrate any harmful effect of the injections on the following parameters: weight, haemoglobin, leucocytes, platelets, serum-protein, serum-alanine-aminotransferase, alkaline phosphatase, liver cell necrosis or hepatic steatosis as compared with a control group. B. Addition of 200 mg HMF/l isotonic NaCl solution did not increase the vein irritating effect of the solution, when given as a 5 hours' continuous intravenous infusion. The amounts of HMF used in this study far exceeded what patients receive from glucose solutions.

Animals↗
PubMed1982

Phosphate addition to glucose solutions- effect on hypophosphataemia and risk of infusionthrombophlebitis.

The object of this study was to show (A) whether the transient fall in plasma phosphate during carbohydrate infusions could be prevented by adding 10 mmol phosphorus to 1 litre of 10% glucose solution, (B) whether this unphysiologically high concentration would change the vein damaging properties of the acid sugar solution, when the phosphorus was added as a phosphate buffer. Study A comprised 16 patients undergoing colonic surgery. On the second postoperative day the patients received 1 litre 10% glucose, half of the solutions were added 10 mmol phosphate buffer. Plasma phosphate dropped during the infusion in all the patients in the unsubstituted group, whereas there was no fall in the phosphate substituted group. The difference between the two groups was significant. Study B comprised 23 rabbits. Sequential analysis demonstrated that the phosphate addition did not change the vein damaging properties of a 10% glucose solution.

Animals↗
PubMed1980

Prevention of hypophosphatemia during postoperative routine glucose administration.

The main study comprised 16 patients undergoing colon surgery. On the day of operation and the 3 following days 100 g of glucose was infused at the rate of 0.3 g/kg/h. Half the patients had 10 mmol of phosphorus added to each 1 000 ml 10% glucose solution. The investigation demonstrated that two different kinds of hypophosphatemia occur in the immediate postoperative period. A significant decrease in fasting plasma phosphate was found at the first, second and the third postoperative morning, most pronounced at the second day (1.20 +/- 0.05 to 0.78 +/- 0.07 mmol/l). A significant correlation between these changes and the corresponding 24-hour phosphorus balance was demonstrated (r = 0.61, p < 0.001). The falls in fasting phosphate could not be prevented by phosphorus addition because an amount of phosphorus corresponding to the amount added was excreted in excess in the urine. The plasma phosphate was decreased furthermore during and even 4 hours after the 5-hour glucose infusion (from 0.76 +/- 0.05 to 0.49 +/- 0.07 nmol/l at the end of the infusion at the second day). This hypophosphatemia was prevented by the phosphorus addition.--In average 3% of the infused sugar was lost in the urine. The solitary examples of higher losses (10-20%) were not followed by a higher urinary production. It is therefore concluded that 0.3 g glucose/kg/h is a suitable infusion rate in the immediate postoperative period.

Colon↗