Biomedical subjects
Publications and source records attributed to A Ravi.
Malignancy has been reported with chronic lymphedema, especially lymphangiosarcoma. The authors report on a patient with lymphedema due to filariasis, presenting with an ulcerated pigmented lesion that was malignant melanoma. A literature search revealed no previous report of such lesions existing together.
Villonodular synovitis are a group of idiopathic lesions that affect the synovial surfaces of joints, tendon sheaths, and bursae, causing tumor-like lesions. Pigmented villonodular synovitis rarely affects the tendon sheaths; its occurrence in extra-articular sites is uncommon. This case is presented for the rarity of occurrence. The literature is also reviewed.
Schwannomas are benign tumors of the nerve sheath, commonly seen in the vestibular nerve. Although they are common in the head and neck areas, their occurrence in extra-cranial locations is rare. We report a case of a sciatic nerve schwannoma and review the literature.
Lupus vulgaris (LV)is a progressive form of cutaneous tuberculosis (TB)that may occur in a patient with a moderate or high degree of immunity. The incidence of LV has declined with that in TB; it is relatively uncommon even in developing countries. LV commonly presents in the head and neck regions as flat plaques. Variants of LV form huge, soft, tumor-like forms with deep tissue and cartilage destruction resulting in deformities. The authors report a case of LV in a patient who presented with an ulcero-proliferative growth in the lower extremity, mimicking a malignancy.
Extra medullary deposits are often associated with myeloproliferative disorders, especially with myeloid neoplasia. These are called granulocytic sarcoma, aleukemic leukemia cutis, myeloblastoma, chloroleukemia, extra-medullary myeloid tumor, and chloroma. They commonly present in the bone, periosteum, soft tissue, lymph nodes, and the skin but can occur anywhere. The authors present their experience with a patient with no history of neoplasm presented with a nonhealing ulcer of the lower limb that was a chloroma associated with chronic myeloid leukemia.
We report the first case of bullous pemphigoid complicating radiation therapy for vulvar cancer. Shortly after completion of postoperative radiation therapy for a TIN1 vulvar carcinoma, the patient presented with a rash that started within, but continued to extend, well beyond the radiation field. A biopsy of the lesions confirmed the diagnosis of bullous pemphigoid, and she had prompt clinical resolution with systemic tetracycline and steroids.
We report a rare case of dual infection in a psoas abscess. Pus from the abscess grew Salmonella typhi and the abscess wall showed epitheloid granulomas giant cells, which we confirmed as tuberculosis by PCR. Such dual infection cases may be missed unless looked for since both these infections are common in our country.
Explore the source record for details and available documents.
A synthetic model peptide, (formula; see text) which mimics the active-site disulfide loop of thioredoxin has been prepared. 270 MHz 1H-NMR studies establish that Cys-4 and methylamide NH groups are solvent-shielded, using hydrogen-deuterium exchange, solvent and temperature dependence of chemical shifts and nitroxide radical-induced broadening as diagnostic criteria. Infrared measurements provide supporting evidence for intramolecularly hydrogen-bonded conformations. The related peptide in which Gly-2 is replaced by alpha-aminoisobutyric acid has been shown to adopt a similar backbone conformation based on NMR and CD data. Based on the known stereochemical preferences of alpha-aminoisobutyric acid residues, a consecutive beta-turn conformation involving two intramolecular 4 leads to 1 hydrogen bonds is proposed for both disulfides. Vicinal coupling constants and CD data are discussed with reference to the side-chain conformation of the cysteine residues. Large structural differences have been established between the thioredoxin active-site model disulfide and its acyclic precursor.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.