A novel pharmacological approach to herpes virus infections.
Explore the source record for details and available documents.
HeLa Cells↗
Biomedical subjects
A Rebuzzini
Publications and source records attributed to A Rebuzzini.
Nucleoside analogs as non-substrate inhibitors of herpes simplex viruses thymidine kinase.
We have examined the capacity of a series of 6-substituted pyrimidine and 2-substituted purine derivatives to inhibit mammalian thymidine kinase and the thymidine kinases encoded by type 1 and type 2 herpes simplex viruses. Several N2-substituted guanine and deoxy guanosine derivatives displayed selective inhibitory activity against the HSV-1 and HSV-2 thymidine kinases by competing with the phosphorylation of thymidine, suggesting a possible novel pharmacological approach to herpes viruses infections.
Cells, Cultured↗
N2-substituted guanine derivatives act as selective non substrate inhibitors of HSV I thymidine kinase.
Explore the source record for details and available documents.
Guanine↗
In vivo distribution and activity of aphidicolin on dividing and quiescent cells.
In view of a possible use of aphidicolin, an inhibitor of DNA polymerases (including viral DNA polymerases), to control excessive cell proliferation we have investigated: the effect of the drug on the growth of several human neoplastic cells; the activity of synthetic analogs aimed at relating the structural feature of aphidicolin to cytotoxicity; the in vivo fate and distribution of aphidicolin in different fluids, organs and tissues of mice following parenteral and/or peroral administration.
Animals↗
DNA methylation and DNA structure.
Explore the source record for details and available documents.
Animals↗