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Biomedical subjects

A Reignier

Publications and source records attributed to A Reignier.

At least 19 recordsLinked to original sources
PubMed1993

[Does manometric megarectum have a symptomatic role in patients complaining of dyschezia?].

UNLABELLED: Adults with dyschezia are occasionally diagnosed as having megarectum when anorectal manometry identifies rectal sensory disturbances. It remains difficult however to ascertain whether this state represents a part of the pathophysiological process responsible for symptoms, or just an associated phenomenon. The aim of this study was to highlight the symptomatic and functional features encountered in patients with dyschezia and megarectum, and to compare them with those obtained in an asymptomatic group and in a group of patients complaining of dyschezia without manometric megarectum. PATIENTS AND METHODS: The maximum tolerable volume (MTV) was defined as the highest tolerable volume which induced painful and irrepressible repletion upon inflation of the rectum with air. The upper normal range of MTV (330 mL) was obtained from rectal manometry performed in a group of 18 healthy volunteers and asymptomatic patients (mean age: 37.8 +/- 14 years, 12 F, 6 M). Between February 90 and February 92, 27 consecutive adults (48 ans +/- 15 years, 26 F, 1 M) suffering from dyschezia were found to have abnormally increased MTV, and were compared to a group of 35 patients (47 +/- 15.3 years, 34 F, 1 M) with dyschezia with MTV within normal ranges. Symptomatic patients underwent detailed interrogation, clinical examination, anorectal manometry, and evacuation proctography. RESULTS: Parity, prevalence of hysterectomy, symptoms and natural history did not differ between the two groups except for increased use of antidepressive agents in the megarectum group.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1989

[Remission of Lambert-Eaton syndrome over a 10-year period. Recurrence without evidence of tumor at autopsy].

A case of Lambert-Eaton's syndrome with onset 18 months prior to detection of an epidermoid cancer of the larynx is reported. Regression of the syndrome, and its total remission over 10 years without treatment following excision of the tumor, suggested a possible relationship as a paraneoplastic disorder. However, doubt was cast on any possible link by recurrence of the Lambert-Eaton's syndrome after 10 years remission, and the satisfactory course without treatment over the next 6 years combined with failure to detect any tumor recurrence or metastases, even at autopsy. The question raised is whether this is indeed a true paraneoplastic affection or a fortuitous association of an idiopathic form of Lambert-Eaton's syndrome and an infrequent cancer which, in addition, has never been reported at the origin of the Lambert-Eaton syndrome.

Aged↗
PubMed1980

[Giant cell thromboangiitis in a patient taking an oral contraceptive (author's transl)].

Pathological examination in a patient who developed an ischemic cerebrovascular accident while taking an oral contraceptive demonstrated widespread lesions in the right and left carotid regions. Histological examination revealed the presence of an obliterating thromboangiitis in the arterial walls, with subendothelial fibrosis of the intima, arterial thrombosis, and a marked giant cell reaction where the lesions were in contact with the internal elastic layer. Immunological and biological anomalies confirmed the inflammatory nature of the lesion with the presence of anti-ethinyl estradiol antibodies in the serum and circulating blood immune complexes. These biological and histological results suggest the immunological nature of the mechanism of origin of the cerebrovascular accident in this case.

Adult↗
PubMed1979

[Syphilitic meningo-encephalitis with probable associated arteritis (author's transl)].

A 21-year-old woman was referred for consultation because of sensory and motor disorders of sudden onset but on lung duration. Neurological examination was normal. Lumbar puncture confirmed the presence of a clear liquid meningitis. Arteriography demonstrated segmental arteritis of the anterior cerebral vessels. Systematic serological tests were positive for syphilis. The authors discuss the relation between arteritis and syphilitic meningitis in this young woman taking oral contraceptives.

Adult↗
PubMed1978

[Neurological disorders and perhexiline maleate therapy. Clinical study of 10 cases. Neuropathological, pharmacocinetic and biochemical studies (author's transl)].

Ten new cases of perhexiline induced peripheral neuropathies are reported. The authors emphasize the possible association of other neurological disorders: cerebellar symptoms in one case, complex tremor in two other cases, marked decrease of photomotor reflexes in one case and disgeusia in another one. The pharmacocinetic study of 4 cases revealed the presence of a low metabolism of the drug in one of them. Polymorphous inclusions have been seen in Schwann cell and endothelial cell cytoplasm in the three patients with electron microscopic study of the nerves. The pathological study of one case showed the demyelination of spinal cord posterior columns. In another case, who died from hepatic coma, the biochemical study of cerebral lipids revealed the low values of cerebrosides and sulfatides in cerebellum and cerebral white matter.

Cerebellar Diseases↗
PubMed1976

Unusual aspects of the dialysis disequilibrium syndrome.

In five patients with chronic renal failure, rapid correction by dialysis of hypertension and/or high blood urea levels provoked acute neurological disorders, followed by slowly reversible neuropsychiatric disturbances. Focal EEG alterations were noted in three patients with normal carotid angiograms. Our cases differed from those usually described as suffering from the dialysis disequilibrium syndrome because of their duration, the severity of mental disturbances, and the asymmetrical pattern of EEG abnormalities. We propose that the symptoms observed could be due to cerebral ischemia. This possibility emphasizes the importance of limiting the duration and efficiency of the first dialyses in patients with severe hypertension and high nitrogen retention, especially if high performance dialyzers are used.

Adult↗