PubMed Health⌕ Search

Biomedical subjects

A Richardson-Jones

Publications and source records attributed to A Richardson-Jones.

5 recordsLinked to original sources
PubMed1992

A method for the independent assessment of the accuracy of hematology whole-blood calibrators.

An independent assessment of the accuracy with which a large manufacturer assigned values to hematologic calibrators was performed. Data were collected from 1,767 hospitals and clinics distributed over North America. Statistical analysis of the mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration of these patient data confirmed the accuracy of the values for hemoglobin, erythrocyte count, hematocrit, and erythrocyte indices for the calibrators manufactured and released during a 9-month period. This approach proved both workable and effective in detecting inaccuracies of less than 1%. Few technologist-users have the time or the equipment to verify independently the accuracy of hematologic calibrators. The manufacturers should perform ongoing, independent assessments of the accuracy of their products. The statistical analysis of patient data provides manufacturers with a suitable method.

Calibration↗
PubMed1990

Assignment of assay values to Coulter controls and calibrators.

The whole blood reference specimens are carefully selected in order to minimize errors in either reference methods or the assay method that might be produced by interferants in the specimens. Fundamental to the process of assigning values to calibrators and controls is the rule that fresh whole blood from normal donors be used as the transfer medium between reference measurement methods and the automated blood cell counter that will be used to assay the stabilized whole blood product. Increasing recognition is being given to the need to adopt K2EDTA salts as global standards for reference specimen anticoagulant. The reference methods used by Coulter closely follow the methods recommended by the Cytometry Panel of the International Committee for Standardization in Haematology and by the National Committee for Clinical Laboratory Standards. Methods used for the statistical control of value assignment are appropriate for commercial rather than institutional use. Simplification of methods is possible because of high levels of test replication and the homogeneous nature of stabilized blood products.

Automation↗
PubMed1985

The Coulter Counter leukocyte differential.

The leukocyte differential counting capability of the Coulter Counter model S-PLUS IV was evaluated for precision, accuracy, and clinical sensitivity. The evaluation used procedures described in the NCCLS tentative standard (H20-T) when these were appropriate for this technology. Within its inherent constraints, the system was found to be more reproducible than the stained-film reference method and at least as accurate. Clinical sensitivity was equivalent to that of a four-slide, microscope differential count. Reference ranges for the cell classes identified by the instrument were similar to those given by the stained-film method.

Biometry↗
PubMedDate not supplied

Continuum analysis method applied to blood count reference intervals.

Conventional methods for extracting reference values from a sample of a purported normal population have a tendency to include some paranormal individuals and to obscure the existence of marginal or subclinical disorders. The suggestion is offered of defining the normal range of an analyte by extrapolation of the portion of its dispersion that fits a continuum. The method softens the present dichotomous character of the reference range. It narrows the normal range of some hematology parameters, suggesting that some paranormal individuals are excluded.

Adolescent↗