PubMed Health⌕ Search

Biomedical subjects

A Riedl

Publications and source records attributed to A Riedl.

8 recordsLinked to original sources
PubMed2004

[Stigmatization. Consideration from a theological-dermatologic perspective].

Stigmatization is associated with considerable psychosocial impairment. Patients with chronic skin disease are especially prone to stigmatization and reduced quality of life. In contrast, patients with self-produced cutaneous artifacts receive an emotional response from family members and doctors. Stigmatization of a religious nature is always difficult for non-participants to understand. We focus on the suffering of the patient, using the example of a historical person, Saint Rita of Cascia, who bore a stigma on her forehead. We discuss why suffering is presented in this manner, and how salvation can be the positive effect of suffering.

Christianity↗
PubMed2001

Developmental regulation of an instability element from the Drosophila fushi tarazu mRNA.

The Drosophila fushi tarazu (ftz) mRNA is one of the shortest-lived metazoan mRNAs, and its instability is crucial for proper development of the embryo. Previously, we identified two cis-acting elements that are required for ftz mRNA degradation, one within the 5' one-third and another in the 3'UTR of the message. Here we focus on the 3'UTR element termed FIE3 (ftz instability element in the 3'UTR). To investigate the developmental regulation of the FIE3-dependent degrading activity we measured the abundance of an FIE3-containing mRNA in ovaries, unfertilized eggs, and different larval and adult tissues. We found that FIE3-degrading activity is present at all developmental stages and tissues examined, except in the ovary. Activation of the FIE3-dependent mRNA decay is independent of fertilization because it could be triggered by egg activation. Finally, we provide evidence that mutation of conserved elements within FIE3 had no effect on mRNA instability.

3' Untranslated Regions↗
PubMed1996

Determinants of Drosophila fushi tarazu mRNA instability.

The fushi tarazu gene is essential for the establishment of the Drosophila embryonic body plan. When first expressed in early embryogenesis, fushi tarazu mRNA is uniformly distributed over most of the embryo. Subsequently, fushi tarazu mRNA expression rapidly evolves into a pattern of seven stripes that encircle the embryo. The instability of fushi tarazu mRNA is probably crucial for attaining this localized pattern of expression. mRNA stability in transgenic embryos was measured by a new method that does not use drugs or external interference. Experiments using hybrid genes that fuse fushi tarazu sequences to those of the stable ribosomal protein A1 mRNA provide evidence for at least two destabilizing elements in the fushi tarazu mRNA, one located within the 5' one-third of the mRNA and the other near the 3' end (termed FIE3 for ftz instability element 3'). The FIE3 lies within a 201-nucleotide sequence just upstream of the polyadenylation signal and can act autonomously to destabilize a heterologous mRNA. Further deletion constructs identified an essential 68-nucleotide element within the FIE3. Lack of homology between this element and other previously identified destabilization sequences suggests that FIE3 contains a novel RNA destabilization element.

Animals↗
PubMed1977

[Functional disorders of distal colon in children (author's transl)].

Functional disorders of the distal part of the colon in neonates and infants should be diagnosed by X-ray investigations (defecograms), double-suction biopsies (Erlanger children suction biopsy apparatus), anorectal and sigmoidal manometry and coloscopic functional investigations. 90% of all disorders of the distal colon can be diagnosed by manometric studies, in 40% X-ray investigations will lead to an exact diagnosis, in 12% double suction biopsies and in 10% coloscopic investigations establish the right diagnosis. The double suction biopsy is important for the exclusion of aganglionosis. Either a conservative or a surgical treatment is necessary, depending on the primary lesion. Wash outs, sphinctertraining, toilet training are necessary in cases of prolonged constipation following sigmaresection with restmegacolon, in cases of rectal inertia syndrom, and in cases of overflow incontinence. A pressure reducing operation (a sphincteromyotomy) is indicated in ultrashort aganglionic segments, in special cases of elongated sigma, in cases of prolonged constipation after sigma resection and with disturbed reflex mechanism, in cases of sphincter inhibition syndrome, and in children with paradox reflex mechanism. A resection is indicated in Hirschsprung disease, mechanical obstruction of the bowel, very large and severe cases of sigma elongatum and in cases of overflow-incontinence.

Biopsy↗