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Biomedical subjects

A Righetti

Publications and source records attributed to A Righetti.

At least 37 records · Page 2Linked to original sources
PubMed1994

Factors influencing the communication of the diagnosis to patients who have cancer.

Medical attitudes and behaviors in communicating diagnoses to patients found to have cancer were investigated in a sample of 126 practitioners in Italy. The research aimed at analyzing the medical approach to oncology patients and how they were provided information about their cancers and relevant treatments. In particular, psychosocial factors influencing the physician's decision whether or not to inform the patient of the diagnosis were examined. The results showed a significant interaction between the working environment and the practitioner's perception of cancer, which can impinge on the decision whether to provide the patient with information.

Adult↗
PubMed1993

Comparison of planar imaging and single-photon emission computed tomography for the detection and localization of coronary artery disease.

Although single photon emission computed tomography (SPECT) has become widely utilized, the superiority of this technique compared to planar conventional imaging remains controversial. In order to compare these two techniques, we retrospectively analysed the results obtained in 70 patients who performed a thallium-201 exercise scintigraphy with a double acquisition during the same test, and who also underwent coronary and ventricular angiography. Overall, SPECT imaging yielded a higher sensitivity (93% vs 82% for SPECT and planar imaging respectively, p < 0.05), especially in the inferior and anterior regions. SPECT was also more sensitive for the detection of a single-vessel disease (90% vs 74% for SPECT and planar imaging respectively, p < 0.01). The specificity was assessed for both techniques with the help of circumferential computerized analysis, avoiding known causes of false positive scintigrams. We found a high specificity for both SPECT and planar imaging, without any significant difference between the two methods (87% vs 91% for the overall specificity of SPECT and planar imaging respectively, p = NS). Therefore, SPECT imaging analysed with discrimination shows an enhanced reliability over planar imaging for the detection and the localization of coronary artery disease, without increasing the risk of false positive tests.

Coronary Disease↗
PubMed1993

Early exercise testing after acute myocardial infarction in the elderly: clinical evaluation and prognostic significance.

Early exercise testing (EET) after acute myocardial infarction (MI) is a well-established means of detecting patients at high risk for subsequent cardiac events. However, the value of this test is not well documented in elderly patients. We evaluated the clinical and prognostic significance of EET in 188 patients, aged 70 years or more, 14 +/- 3 days after an uncomplicated acute MI. The mean follow-up period was 3.6 years (range 1 to 6 years) in 95% of the patients. The total mortality rate was 13.5% (24/178) and the cardiac-related mortality rate was 7.8% (14/178), with 64% of the deaths occurring in the first 3 years. There were no complications during EET. The following parameters measured during EET on a bicycle ergometer were predictive of subsequent cardiac death: an increase in systolic blood pressure of less than 30 mm Hg (p < 0.001), an increase in the double product of less than 12,500 mm Hg.beats/min (p < 0.001), a maximal load less than 60 W (p < 0.001), and a total duration of exercise less than 5 minutes (p < 0.001). The combination of these four parameters increased the predictive value of the test (p < 0.0001). ST segment depression and ventricular arrhythmias during exercise were not correlated with the incidence of subsequent cardiac death, but the degree of ST segment depression was directly and significantly (p < 0.0001) associated with the incidence of subsequent nonlethal cardiac events (coronary bypass surgery, coronary angioplasty, reinfarction, or unstable angina).(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1993

Cooperatives as a social enterprise in Italy: a place for social integration and rehabilitation.

This article analyses the history and development of an integrated cooperative established in 1981 in northern Italy. Integrated cooperatives, otherwise known as social enterprises, are among the most interesting activities developed in the area of social assistance and rehabilitation in recent years in Italy. In particular, they acquired relevance in the care of mentally disordered people by providing them with job opportunities, which is an important rehabilitative and integrative factor. The aim of social enterprises is two-fold. They have the economic goal of offering remunerative work just as any other commercial enterprise, as well as the social mandate of promoting the physical, social, and mental health of their members. A positive coexistence between market competition and rehabilitation is therefore constantly pursued. This research aimed at analysing the working and social experience of people employed by the cooperative during its 10-year life. The study was limited to those who had a social or health problem when entering the cooperative. The investigation was promoted by cooperative members, who felt the need to document their experience and to undertake initiatives towards evaluating the rehabilitative value of the social enterprise. The results show that cooperative members come from different marginalized areas of social and health distress, of which the two largest are social service users and psychiatric service users. There is a noticeable turn-over rate, which underlines one function of the cooperative as being a transitional working context from which users can gain access to other more rewarding job opportunities in the labour market.

Adult↗
PubMed1993

Early stress tests after successful coronary angioplasty.

The aim of this study was to determine feasibility, safety and yield of early stress tests after successful coronary angioplasty. In 351 consecutive patients with an early stress test performed within 3 days after successful coronary angioplasty, no cardiac or puncture site complications occurred. Seventeen percent of the stress tests remained positive after successful coronary angioplasty. An angiographic explanation, based on the data collected at the time of the angioplasty procedure, was present in 82% of the cases. Positive early stress tests typically only prompted modifications of the drug regimen.

Angioplasty, Balloon, Coronary↗
PubMed1992

Effects of exercise test on plasma markers of an activation of coagulation and/or fibrinolysis in patients with symptomatic or silent myocardial ischemia.

It has been suggested that unstable angina at rest, like acute myocardial infarction, might be associated with a thrombotic process. In order to study the hypothesis that myocardial ischemia during exercise could also be associated with an activation of blood coagulation and/or fibrinolysis, we investigated the presence of plasma markers of a prethrombotic or thrombotic state (thrombin-antithrombin III complexes TAT, prothrombin fragment F1 + 2, and D-dimers DD) in 100 consecutive patients with confirmed or suspected coronary artery disease during ergometric test with myocardial thallium-201 scintigraphy. Symptoms and scintigrams allowed to define three groups of patients: those showing no ischemia (n = 79) and those with symptomatic (n = 8) or silent myocardial ischemia (n = 13). Before exercise, DD and TAT levels were not significantly different among the three groups. On the other hand, the F1 + 2 levels were slightly albeit significantly higher in the patients without ischemia than in the patients with symptomatic or silent ischemia. After exercise, no significant difference was found between the three groups. Exercise induced a significant and parallel increase in both the TAT and the F1 + 2 levels (but not of the DD levels) in the three groups. Thus, our study does not support the hypothesis that myocardial ischemia, silent or symptomatic, is associated with an activation of plasma coagulation and fibrinolysis that can be distinguished from the exercise-induced thrombin generation.

Adult↗
PubMed1992

Limits of thallium-201 exercise scintigraphy to detect coronary disease in patients with complete and permanent bundle branch block: a review of 134 cases.

We reviewed the records of 68 patients with right bundle branch block (RBBB) and 66 patients with left bundle branch block (LBBB), who had undergone thallium-201 exercise scintigraphy and coronary arteriography, to determine the sensitivity, specificity, and positive and negative predictive values of thallium-201 imaging for the detection of coronary artery disease in the presence of intraventricular conduction abnormalities. In patients with RBBB the sensitivity, specificity, and positive and negative predictive values were, respectively, 83%, 89%, 79%, and 92% for the anteroseptal region and 83%, 84%, 83%, and 84% for the inferoposterior region. In patients with LBBB these values were, respectively, 94%, 33%, 36%, and 93% for the anteroseptal region and 77%, 90%, 81%, and 88% for the inferoposterior region. In this second group defects limited to the septal region were a good predictor of false positive scintigrams (9/10 cases), but if apical defects used as the sole criterion for detecting lesions in the left anterior descending artery improved the specificity to 85%, the sensitivity was greatly reduced (35%). We conclude that exercise scintigraphy is a reliable method for detection of coronary lesions in patients with RBBB and in patients with LBBB and inferoposterior perfusion defects, but it is unable to discriminate between normal subjects and patients with coronary disease in the presence of LBBB and anteroseptal perfusion defects. In addition, limited septal defects are highly suggestive of false positive scintigrams in this latter group of patients.

Adult↗
PubMed1992

Computer probability estimates of angiographic coronary artery disease: transportability and comparison with cardiologists' estimates.

A computer algorithm for estimating probabilities of any significant coronary obstruction and triple vessel/left main obstructions was derived, validated, and compared with the assessments of cardiac clinician angiographers. The algorithm performed at least as well as the clinicians when the latter knew the identity of the patients whose angiograms they had decided to perform. The clinicians were more accurate when they did not know the identity of the subjects but worked from tabulated objective data. Referral and value induced bias may affect physician judgment in assessing disease probability. Application of computer aids or consultation with cardiologists not directly involved with patient management may assist in more rational assessments and decision making.

Adult↗
PubMed1992

Exercise-induced ST depression and ST/heart rate index to predict triple-vessel or left main coronary disease: a multicenter analysis.

The aim of this investigation was to determine the difference in accuracy between two frequently published noninvasive indicators of severity of coronary artery disease (exercise-induced ST segment depression and heart rate-adjusted ST depression [ST/HR index]). The study was designed as a survey of consecutive patients undergoing exercise electrocardiography and coronary angiography. There were a total of 2,270 patients without prior myocardial infarction or cardiac valvular disease referred for angiography from eight institutions in three countries; 401 of these patients had triple-vessel or left main coronary artery disease. The sensitivities of ST depression and ST/HR index in detecting triple-vessel or left main coronary artery disease were, respectively, 75% and 78% (p = 0.08) at cut point values where their specificities were equal (64%). This small increase in the accuracy of the ST/HR index was evident only at peak exercise heart rates below the median value of 132 beats/min, where the sensitivities of ST depression and ST/HR index were 73% and 76% (p = 0.03), respectively, at cut point values corresponding to a specificity of 60%. These results were consistent at all eight participating institutions. The increase in accuracy achieved by dividing exercise-induced ST depression by heart rate is small and confined exclusively to a low exercise heart rate. This lack of superiority cannot be generalized to all methods of heart rate adjustment.

Bias↗
PubMed1992

Effects of oral isradipine on left ventricular function at rest and during exercise in patients with stable chronic angina: a double-blind, placebo-controlled crossover study.

We evaluated the effects of a single oral dose of 5 mg of isradipine compared to placebo in a randomized, double-blind, crossover study using gated radionuclide angiography at rest and during exercise in 20 patients with stable chronic angina. Isradipine improved both anginal symptomatology and ST-segment depression during exercise, with a concomitant favorable effect on the isotopic parameters exploring systolic and diastolic left ventricular function. There was a marked increase of the ejection fraction during exercise with isradipine compared to placebo (61 +/- 14% vs. 55 +/- 15%, respectively, p less than 0.001) as well as a significant improvement in the peak ejection rate and the peak filling rate at rest [2.56 +/- 0.62 vs. 2.16 +/- 0.54 end diastolic volume (EDV) per second and 2.14 +/- 0.59 vs. 1.87 +/- 0.37 EDV/s, respectively] and during exercise (3.49 +/- 0.97 vs. 3.10 +/- 1.07 EDV/s and 4.05 +/- 1.34 vs. 3.65 +/- 1.25 EDV/s, respectively). We conclude that isradipine has a beneficial effect on the clinical and electrocardiographic signs of exercise-induced ischemia, leading to a significant improvement of the systolic and diastolic parameters of left ventricular function. Therefore, isradipine is potentially a useful treatment for patients with exertional angina and hypertension, alone or associated with beta blocker medication.

Adult↗
PubMed1991

[Effect of high-dose verapamil on systolic and diastolic cardiac function of non-cardiological patients and review of the literature].

We studied the effects of high doses of oral verapamil (480 mg daily) in a group of 28 patients undergoing intravenous drug therapy for terminal digestive tumor. One additional patient was prematurely withdrawn from the study due to the occurrence of second degree atrioventricular block, which regressed after the interruption of verapamil. Gated radionuclide angiocardiography was performed before and after treatment (mean duration 2 days). Verapamil induced a significant reduction of blood pressure and heart rate (132 +/- 19 mm Hg vs 124 +/- 18 mm Hg, p = 0.005 for systolic blood pressure, 80 +/- 13 mm Hg vs 76 +/- 9 mm Hg, p = 0.04 for diastolic blood pressure and 81 +/- 17 bpm vs 77 +/- 13 bpm, p = 0.02 for heart rate). Left ventricular ejection fraction and peak filling rate were not impaired (65 +/- 7% vs 64 +/- 7%, p = NS and 2.52 +/- 0.65 EDV/s vs 2.42 +/- 0.51 EDV/s, p = NS), while peak ejection rate decreased slightly (2.96 +/- 0.72 EDV/s vs 2.72 +/- 0.50 EDV/s, p = 0.01). Conversely, there was significant alteration of right ventricular systolic indexes (50 +/- 7% vs 46 +/- 7%, p = 0.01 for the ejection fraction and 2.06 +/- 0.53 EDV/s vs 1.88 +/- 0.44 EDV/s, p = 0.008 for the peak ejection rate), without change in the peak filling rate (1.54 +/- 0.46 EDV/s vs 1.46 +/- 0.46 EDV/s, p = NS).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1990

Long-term results of successful and failed angioplasty for chronic total coronary arterial occlusion.

The results over a mean period of 2 years of successful percutaneous transluminal coronary angioplasty (PTCA) in 100 consecutive patients with chronic total coronary occlusion were compared with those in 100 consecutive patients whose PTCA was unsuccessful. The groups were comparable in terms of gender, age and arteries attempted. A control angiography in the group with successful PTCA was performed in 62 patients and showed a restenosis in 28 (45%). Repeat PTCA was performed in 21 versus 1 patient with failed PTCA (p less than 0.0001). At follow-up, in the group with successful PTCA, there were 57 symptom-free patients versus 26 patients in the group with failed PTCA (p less than 0.0001). Coronary artery bypass surgery was performed in 7 versus 37 patients (p less than 0.0001), and there were 5 versus 3 deaths (difference not significant), respectively. In the group with successful PTCA, 27 of 82 patients (33%) had positive stress test results, compared with 49 of 85 patients (58%) in the group with unsuccessful PTCA (p less than 0.001). The double product (beats/min x mm Hg/100) in patients with successful PTCA improved from 247 +/- 57 before PTCA to 277 +/- 61 (p less than 0.001) at follow-up, whereas it did not significantly change in patients with failed PTCA. The work load (W) in patients with successful PTCA improved from 95 +/- 34 before PTCA to 124 +/- 40 at follow-up (p less than 0.001). In patients with failed PTCA, work load improved less significantly, from 98 +/- 37 before PTCA to 108 +/- 34 at follow-up (p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Angioplasty, Balloon, Coronary↗
PubMed1990

Computerized determination of lactate threshold during three modes of exercise.

The lactate threshold (LT) and corresponding exercise levels (rate-pressure product, workload, and exercise duration) have been proposed as objective quantitative parameters of functional capacity and cardiovascular status. The purpose of the present study was to compare three modes of exercise and to evaluate the influence of the body position, using a rapid lactate analyser and computerized determination of the LT. Eight healthy male subjects were studied. No significant difference was found between the LT measured during treadmill (1.55 +/- 0.22 mmol/l), upright bicycle (1.61 +/- 0.17 mmol/l), and supine bicycle (1.41 +/- 0.05 mmol/l) exercises. However, while exercise levels corresponding to the lactate threshold were similar in running and upright bicycling, the supine bicycle was associated with lower exercise duration and workload corresponding to the LT.

Adult↗
PubMed1989

[Diagnosis of acute myocardial infarct using 2 new tracers: 111indium-labeled antimyosin antibodies and 99m-technetium isonitriles].

The clinical usefulness of scintigraphies with 111Indium radiolabeled antimyosin antibodies (Myoscint) and 99mTc isonitriles (Cardiolite) for the detection and topographic location of acute myocardial infarction (AMI) has been evaluated in 29 patients admitted for suspected AMI. The scintigraphic results were compared to ECG and enzymatic data and, in 22 patients, to coronaro-angiography. The CK enzymes (from 258 to 4986 IU/l, mean 1429) were elevated in all, while the ECG showed diagnostic Q waves in only 21 patients. 2 patients died in cardiogenic shock, one after massive extension of AMI. Myoscint and Cardiolite images were positive in all 29 patients. Both techniques showed concordant results in 27/28 comparable patients, and localized the AMI in 8 patients without diagnostic ECG. Regional comparison in 140 segments of 28 patients was concordant in 91% of the segments, totally discordant in 3 segments and partially discordant in 9 segments. In conclusion, this preliminary study in selected patients shows the clinical usefulness of 111In radiolabeled antimyosin antibodies and 99mTc isonitriles for detection of AMI in all 29 patients and for topographic localization in more than 90% of the cases. Imaging with 111In radiolabeled antimyosin antibodies seems particularly useful in patients with non diagnostic ECG and previous MI and for the detection of right ventricular infarct extension.

Acute Disease↗
PubMed1989

Radionuclide evaluation of right ventricular wall motion after surgery in tetralogy of Fallot.

Regional wall motion patterns in tetralogy of Fallot and its postoperative modifications by electrical and hemodynamic factors were assessed by Fourier analysis of gated radionuclide angiograms in 24 studies performed in children after surgical correction of tetralogy of Fallot. The range of right ventricular (RV) phase angles (standard deviation of the peak [SDP] of RV) as well as the difference between RV and LV (delta MPh) were used as indices of the synchronicity of wall motion and were correlated with RV apical electrical activation time determined by endocardial electrical mapping. Postoperative studies were divided into two groups according to apical activation: (a) those involving right bundle branch block (RBBB) (nine patients), and (b) those involving distal RBBB (15 patients). delta MPh was longer in proximal than in distal RBBB. Best discrimination between the two groups was obtained with SDP of RV (proximal = 24 degrees +/- 3 degrees, and distal = 17 degrees +/- 2 degrees; p less than 0.0001). These results showed that the range of ventricular phases measured by the SD of the phase distribution of the right ventricle is a good index for distinguishing between proximal and distal RBBB after cardiac surgery.

Adolescent↗