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Biomedical subjects

A Riley

Publications and source records attributed to A Riley.

10 recordsLinked to original sources
PubMed1987

Reproducibility of oesophageal transit studies: several 'single swallows' must be performed.

The 'single swallow' technique for the isotopic investigation of oesophageal function has been widely accepted. In our experience the results obtained when several consecutive 'single swallow' tests are performed show considerable variation. Although one or two swallows may be enough to diagnose abnormality, the exclusion of a motility disorder requires more, preferably six consecutive swallows.

Adult↗
PubMed1987

Initial clinical experience with degradable starch microspheres.

Four patients with advanced hepatic malignancy have been investigated with a view to intra-arterial treatment with degradable starch microspheres (DSM) and mitomycin-C (MMC). Computer-assisted interpretation of data gathered during the administration of technetium-labelled albumin allows the degree of arteriovenous shunting within the liver to be measured. In a similar way, the effectiveness of DSM in blocking hepatic arterial flow is determined. Two patients showed unacceptably high levels of shunting (75% and 100%) and were excluded from further study. One patient with hepatocellular carcinoma shunted only 24% of the macroaggregated albumin, and flow through the liver was reduced to 48% by DSM therapy. This patient has undergone four courses of MMC without significant toxic complications. The last patient had 25% shunting. The DSM titration and the first MMC administration had to be abandoned because of severe abdominal pain and nausea related to a fracture of the intra-arterial catheter. Complications directly associated with the procedures have been acceptable. The relationship between flow reduction and the amount of DSM administered is non-linear, and the appropriate dose of DSM for each treatment must be titrated against both the patient's symptoms and the computer-generated flow indices.

Adult↗
PubMed1986

A new approach to the construction of small animal inhalation chambers: design and evaluation.

Cylindrical, all glass, inhalation chambers are described which are suitable for the exposure of small laboratory animals to atmospheric pollutants. The main feature of the design is the ability of the investigator to construct a chamber with an internal volume which best approximates the animal loading requirement and/or the availability of test material. Evaluation of the distribution of a gaseous material within the chamber has shown that animals will be exposed to a specified atmospheric concentration of the material irrespective of their position within the chamber. Catch pans for the collection of excreta can be used which do not affect the uniformity of material distribution. Preliminary evaluation of the distribution of a particulate atmosphere indicates that the same will be true for liquid and solid aerosols.

Animals↗
PubMed1975

Stimulation effect of prostaglandin F2ALPHA on the plasma concentration of testosterone in bulls.

The concentrations of peripheral plasma testosterone were measured by radioimmunoassay in samples collected from five bulls, each given i.m. injections of 0, 5. 15, 30 and 60 mg prostaglandin F2alpha (PGF2alpha). Synchronized peaks in testosterone concentration occurred with maximum values 1.2h after treatment. These increases of testosterone persisted significantly longer than those observed to occur as natural episodic peaks during two 24 h periods in the same bulls. The mean peak testosterone concentration after PGF2alpha injection was related to the dose of PGF2alpha, values after 60 and 30 mg doses being significantly greater than after 15 mg. The response produced by a 5 mg dose was not significant. The results indicate that intramuscular injection of PGF2alpha, acutely stimulates synthesis and release of testosterone in fulls.

Animals↗