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A Rioseco

Publications and source records attributed to A Rioseco.

8 recordsLinked to original sources

Plasma prolactin/oestradiol ratio at 38 weeks gestation predicts the duration of lactational amenorrhoea.

BACKGROUND: Fully breastfeeding women experience an amenorrhoea of variable duration. Our aim was to identify in pregnancy, endocrine markers that could predict the duration of subsequent lactational amenorrhoea. METHODS: We studied 17 healthy women at 34 and 38 weeks gestation, and 1 and 3 months post-partum. The women fully breastfed until 6 months post-partum. During pregnancy, prolactin (PRL), oestrogens (total oestradiol, unconjugated oestrone, unconjugated oestriol), sex hormone binding globulin (SHBG), dehydroepiandrosterone sulphate (DHEA-S), progesterone and placental lactogen, and during post-partum PRL, oestrogens and SHBG, were measured. Free oestradiol in pregnancy and post-partum was calculated. RESULTS: Ten women experienced long (>6 months) and seven experienced short (<6 months) lactational amenorrhoea. At 38 weeks gestation, the women who experienced a long lactational amenorrhoea had twice as much PRL, about half the total oestradiol, lower SHBG concentration (P < 0.05, Student's t-test, Bonferroni modification) and similar free oestradiol concentration, compared with those who experienced short lactational amenorrhoea. The difference in PRL concentration persisted in post-partum postsuckling samples. CONCLUSION: At 38 weeks gestation, the ratio PRL/oestradiol identified all individual women according to the subsequent duration of their lactational amenorrhoea, suggesting that duration of lactational amenorrhoea is conditioned during pregnancy.

Adult↗

[Spontaneous regression of a cystic hygroma].

A case of a nonseptated cystic hygroma with spontaneous resolution in utero is presented. The clinic, sonographic, and morphologic findings as well as the prognosis of septated and nonseptated cystic hygromas are discussed.

Adult↗

Surgery, BCG immunotherapy, and multichemotherapy in T3 stage-3 bronchogenic carcinoma.

Thirteen consecutive unselected patients suffering from stage-3 bronchogenic carcinomas (12 with T3 tumors and one T2 primary bilateral simultaneous carcinoma) underwent surgical resection followed by intrapleural, deep upper bilateral intercostal injections and oral immunostimulation with living fresh Pasteur strains of bacillus Calmette-Guérin (BCG). Since the 30th postoperative day, patients were started on intermittent multichemotherapy with suboptimal doses of methotrexate, 5-fluorouracil, and cyclophosphamide associated with oral therapy with BCG. The length of survival in the "study group" was compared to the results observed in nine unselected, consecutive, and concomitant semirandomized patients with T3 stage-3 carcinomas treated with cobalt therapy plus identical immunochemotherapy (control group A). Comparison of results was also made with 69 out of 100 consecutive patients with T3 stage-3 unresectable carcinomas who survived longer than two months after exploratory thoracotomies (control group B), representing the natural course of unresectable cases. Twelve (92 percent) of the 13 patients in the study group survived longer than six months, ten (77 percent) survived more than 12 months, six (46 percent) lived 18 months or more, and five (37 percent) have surpassed the 24th month of survival to date. Differences in survival at 6, 12, 18, and 24 months and the average length of survival in the study group to date (19.1 months) are statistically significant when compared to control groups A and B. The quality of postoperative life measured by the performance status according to Karnofsky's scale demonstrates an average of 79.3 percent for the entire study group.

Adult↗

Antibiotic treatment in preterm labor and intact membranes: a randomized, double-blinded, placebo-controlled trial.

Although an association between microbial invasion of amniotic cavity and preterm birth has been extensively demonstrated, there is conflicting evidence regarding the benefits of antibiotic therapy in patients with preterm labor and intact membranes. We attempted to assess the efficacy of amoxicillin and erythromycin on pregnancy outcome in those patients. A randomized, double-blinded, placebo-controlled trial was designed and implemented. A total of 196 patients with singleton pregnancies and preterm labor with intact membranes (22-36 weeks) were randomly allocated to receive either antibiotics or placebo, plus adjunctive parenteral tocolysis, and 173 patients (antibiotics group n = 83 vs. placebo group n = 90) completed the treatment. The overall prevalence of microbial invasion of the amniotic cavity was 5.2% (9/173). No significant difference between both groups was found in maternal outcomes, including duration of randomization-to-delivery interval, frequency of preterm delivery, and frequency of clinical chorioamnionitis and endometritis. Rate of cesarean section was significantly higher in the placebo group (28% vs. 12%). Regarding neonatal outcome, no significant difference was detected between both groups in neonatal death, respiratory distress syndrome, proven sepsis, and birthweight. Suspected sepsis was significantly more frequent in the placebo group (6/90 vs. 0/78). The results of this trial indicate that amoxicillin and erythromycin do not prolong pregnancy in patients with preterm labor and intact membranes. A significant reduction in the rate of cesarean section was observed in patients receiving antibiotics. A significant reduction in the rate of neonatal suspected sepsis was also demonstrated.

Adult↗