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Biomedical subjects

A Rodriguez

Publications and source records attributed to A Rodriguez.

At least 379 records · Page 21Linked to original sources
PubMed1978

Transcatheter embolization of autologous clot in the management of bleeding associated with fractures of the pelvis.

Extraperitoneal hemorrhage, associated with a fracture of the pelvis, is a major cause of death in pedestrian accidents. Transfusion alone may be unsatisfactory. Direct control of bleeding may be required. Surgically, this may be technically difficult or inadequate. Transcatheter embolization of autologous clot was used to control hemorrhage in three patients with such a fracture. If laparotomy is required immediately, arteriography of the pelvic area may be done postoperatively, If laparotomy is not performed, arteriography may define pelvic bleeding sites. Transcatheter embolization of autologous clot controls hemorrhage from branches of the hypogastric artery.

Accidents, Traffic↗
PubMed1977

Diagnosis of retinoblastoma by cytologic examination of the aqueous and the vitreous.

Cytological examination by aspiration of the aqueous and the vitreous can be an additional useful technique to aid in the diagnosis of certain anteriorly located unusual appearances of retinoblastoma with opaque media, particularly if the information from ultrasound is not available or is unsatisfactory. A positive cytological diagnosis should be immediately followed by enucleation. Personal experience is presented.

Aqueous Humor↗
PubMed1976

Ethylenimine-inactivated rabies vaccine of tissue culture origin.

The replication of seven rabies virus strains (CVS, HEP, PV, ERA, WIRAB, CPZ and BOLIVAR) in BHK cells and the inactivation dynamics of these strains by beta-propiolactone, acetylethylenimine, and ethylenimine were studied to find the most immunogenic strain and the most economic and stable inactivating agent for the production of an inactivated tissue culture rabies vaccine for animal use. The seven strains reached the peak of virus production 3 to 5 days after inoculation of the cell culture; PV yielded the highest virus titer (10(9) plaque-forming units/ml). The infectivity of virus suspensions containing 10(7) to 10(8) plaque-forming units/0.1 ml was inactivated by beta-propiolactone in 0.5 h, acetylethylenimine in 3.0 h, and ethylenimine in 1.0 h. Most of the vaccine lots prepared with the different strains and inactivating agents passed a modified National Institutes of Health potency test. The vaccines prepared with the PV strain had consistently higher antigenic values (equal or better than four) than the other six strains. This difference was highly significant (F6,12=59.8), whereas there were no statistically significant differences among the antigenic values of the vaccine lots prepared with the three inactivating agents. Batches of lyophilized and liquid vaccine stored at 4 C maintained potency for over 1 year. Ten dogs vaccinated with a vaccine prepared with the PV strain and inactivated with ethylenimine developed a good antibody response and resisted challenge 60 days after vaccination, while seven of eight nonvaccinated controls died of rabies. This information indicates that an inactivated, stable, economic, and easy-to-prepare rabies vaccine can be produced in BHK cells by using the PV strain and ethylenimine as an inactivating agent.

Animals↗
PubMed1976

Pituitary and testicular response to hypothalamic LH-releasing hormone (LH-RH) in normal and oligospermic men.

A comparative study was done of the basal and post-LH-RH stimulation levels of LH, FSH and Testosterone (T) in 10 healthy, male volunteers, aged 24-35 years, and in 25 normogonadotropic oligospermic men aged 23-43 years in whom other endocrine, urologic and/or vascular diseases had been rules out. Seventeen of the latter group underwent bilateral testicular biopsy. Each subject received rapid i.v. injection of 50 mug synthetic LH-RH at 8:00 A.M. Serum levels of LH, FSH and T were determined by radioimmunoassay on samples obtained immediately before and 30 and 45 minutes after injection. As compared to normals, oligospermic men had a lower average LH response, although the basal values did not differ significantly from normal. FSH levels did not differ significantly between groups, although some individual patients showed higher and some lower than normal values. The possibility of stimulating T secretion with LH-RH was confirmed. Average serum T levels rose more slowly and reached lower levels in the oligospermic men than in normal men. There was no correlation between LH and FSH rises. It is postulated that some patients with normogonadotropic oligospermia may have latent insufficiency of pituitary gonadotropic functional reserve for one or both hormones and/or of the Leydig cell function. The need for individual analysis of results and their correlation with testicular biopsy findings is commented.

Adult↗
PubMed1976

Characterization of T4 mutants that partially suppress the inability of T4rII to grow in Lambda lysogens.

In the course of isolating viable T4 deletions that affect plaque morphology (HOMYK and WEIL 1974), two closely linked point mutant, sip1 and sip2, were obtained. They map between genes t and 52, cause a reduction in plaque size and burst size, and partially suppress the lethality of rII mutants for growth in lambda lysogens. The characteristics demonstrate that sip1 and sip2 are similar to mutants previously reported by FREEDMAN and BRENNER(1972). In addition, D. Hall (personal communication) has shown that sip1 and sip2 are similar to the mutant farP85, which affects the regulation of a number of early genes (Chace and Hall 1975).--Sip suppression of rII mutants can be demonstrated in one-step growth experiments, even when both rII genes are completely deleted. This indicates that sip mutants do not simply reduce the level of rII gene products required for growth in a lambda lysogen. Instead, they alter the growth cycle so as to partially circumvent the need for any rII products.--Mutations at two other sites, designated L1 and L2, reverse the poor phage growth caused by sip and, in the one case tested, reverse the rII-suppressing ability of sip.

Chromosome Deletion↗
PubMed1975

Infantile autism. I: A prospective study of the diagnosis.

A prospective study was made of 200 consecutive children to evaluate the usefulness in the diagnosis of infantile autism of the behavioral scale reported by Clancy and coworkers in 1969. On this scale seven or more of 14 behavioral manifestations must be present before a diagnosis of autism can be made. Using this scale alone, 48 of the 200 children studied were "scale positive", i.e. could be considered autistic. However, further study of this group showed that only one child fulfilled the classical criteria of Kanner (1943) for a diagnosis of early infantile autism. Scale "positivity" was found to correlate with mental retardation and to be associated with other developmental defects, especially learning disorders and hearing loss.

Adolescent↗
PubMed1975

Intraocular injection of balanced salt solution and/or air as aids in the release of subretinal fluid.

Intraocular BSS and air used in combination with buckling procedures and exoplants have been helpful as aids in the release of subretinal fluid. BSS can be injected into the anterior chamber or through the pars plana and the buckling area. Air should only be injected through the pars plana. The advantages are discussed. Careful technique is generally exempt of complications.

Adolescent↗
PubMed1975

Late removal of dense posthemorrhagic vitreous membranes following cataract extraction.

Severe, seemingly permanent intraocular hemorrhages caused by ocular trauma, Eales' disease and retinal vein thrombosis, lead to late formation of a dense retrolental membrane, vitreous liquefaction and intumescent cataract with faulty light perception. In the absence of ultrasound, the diagnosis was made possible only after removal of the cataract. Lens extraction and excision of the vitreal membrane led to surprisingly good recovery of vision. Three cases are presented and the pathological study of a posthemorrhagic membrane.

Adult↗