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Biomedical subjects

A Rook

Publications and source records attributed to A Rook.

At least 19 recordsLinked to original sources
PubMed1992

Treatment of erythrodermic cutaneous T-cell lymphoma with extracorporeal photochemotherapy.

BACKGROUND: This original cohort of patients with erythrodermic cutaneous T-cell lymphoma (CTCL) was reported to have clinical improvement with photopheresis during the 12 months of the original study. No long-term follow-up data have been available to examine the impact of this therapy on the disease. OBJECTIVE: Our purpose was to provide long-term follow-up on the original 29 erythrodermic CTCL patients treated with photopheresis and to compare these results with historical controls. METHODS: Files of patients from the original photopheresis study centers were reviewed and their current status was documented. RESULTS: The median survival of the treated patients was 60.33 months from the date of diagnosis and 47.9 months from the date of the start of photopheresis therapy. A complete remission has been maintained in four of the six patients who achieved complete responses in the original study. The best responses were seen in patients with a lower CD4/CD8 ratio in the peripheral blood at the start of therapy. CONCLUSION: Photopheresis can influence the natural history of erythrodermic CTCL by inducing remissions and prolonging survival with minimal toxicity.

CD4-CD8 Ratio↗
PubMed1990

A controlled trial of intralesional recombinant interferon-gamma in the treatment of keloidal scarring. Clinical and histologic findings.

Interferon-gamma (IFN-gamma) suppresses the synthesis of collagen by fibroblasts in vitro and the synthesis of collagen in vivo in animal models. Therefore, recombinant human IFN-gamma was examined for its ability to clinically modify keloids. Subjects were treated by injection of either 0.01 or 0.1 mg of recombinant human IFN-gamma into one lesional site and diluent alone into another lesional site three times per week for 3 weeks. Keloids were measured and photographed before beginning therapy and weekly thereafter. Three days after the final injection, biopsies were performed on treated and control sites. Six of eight subjects who finished the course of treatment demonstrated reduction in size at the treated site with an average reduction in height of 30.4% vs 1.1% for control sites. Lesions treated with recombinant human IFN-gamma demonstrated alterations in both the epidermis and dermis. The epidermis showed thinning of the suprapapillary plates, compact hyperkeratosis, focal or diffuse parakeratosis, exocytosis of lymphocytes, and an increased quantity of mucin. The dermis contained a diminished quantity of thickened collagen bundles and active fibroblasts and an increased number of inflammatory cells and quantity of mucin. These results suggest the feasibility of using IFN-gamma in the treatment of abnormal fibrosis. Dose-ranging studies are required to establish whether IFN-gamma can fulfill a true clinical need in the treatment of keloidal scarring.

Adolescent↗
PubMed1989

[Family groups and family self-help groups for schizophrenic patients. Concepts, establishment, problems in implementation].

In Münster/W.-Germany the effect of therapeutical work with relatives of young schizophrenic patients is investigated in a government supported prospective study. In this paper we reveal therapeutical concepts and difficulties dealing with the formation and guidance of the relatives groups. After a personal interview about one third of the relatives was interested in relatives groups (151 relatives of 99 patients). Relatives of younger patients with a shorter duration of illness were somewhat more interested. During the one-year-period of group-work about one third of the relatives left the groups. The motivation for a regular participation dependent on the symptoms of the patients. A special training produced better motivation for taking part in long-term self-help-groups.

Adult↗
PubMed1979

Results of retransplantation in individuals who received two successive cadaver kidneys.

At the Royal Victoria Hospital in Montreal, 22 patients received two successive cadaver renal transplants. The results were analysed to determine which factors have the best predictive value for success or failure in renal retransplantation. The fate of a second cadaver renal allograft was found to be about the same as the first if the initial transplant has been lost because of rejection and not technical failure. The duration of survival of the initial transplant serves as the best guide to potential outcome of retransplantation after rejection of the initial graft.

Adolescent↗
PubMed1976

Congenital triangular alopecia.

Three new cases of congenital triangular alopecia are reported and the differential diagnosis of this rare developmental defect is discussed.

Alopecia↗
PubMed1975

The first experiences with ether anaesthesia in Cambridgeshire and West Suffolk 1847.

A search through the files of a local newspaper, the Cambridge Chronicle, has brought to light in numerous references to ether anaesthesia during the years 1847 and 1848. From this and other sources it has been possible to establish that the first operation under ether was performed at Addenbrooke's Hospital, Cambridge on 2 January 1847, only 12 days after Liston's well known demonstration in London. By 13 March over fifty operations under ether had been successfully carried out at this hospital. The first experiences with ether at Wisbech, Cambridgeshire and Bury St Edmunds, West Suffolk are also described. It is suggested that much material important in determining the extent to which the practice of anaesthesia was rapidly adopted in the English provinces awaits the historian in the local newspaper, since the early experiences with anaesthesia were often not recorded in the Minute Books of hospital committees, and indeed, often took place outside the hospitals.

Anesthesia, Dental↗