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Biomedical subjects

A Rose

Publications and source records attributed to A Rose.

At least 109 records · Page 6Linked to original sources
PubMed1984

Effects of mianserin on noradrenergic mechanisms.

Mianserin increased stimulation-induced release of noradrenaline from guinea-pig atria and brain cortex slices. The increase still occurred when neuronal reuptake of noradrenaline was blocked by cocaine. Mianserin blocked the neuronal uptake of 3H-noradrenaline only in high concentrations (1 microM in atria produced 40% block; 10 microM in cortex produced 57% block). Lower concentrations (0.01 microM in atria; 1 microM in cortex) significantly increased stimulation-induced release of noradrenaline. It is concluded that increases in transmitter release from noradrenergic nerves produced by mianserin can be attributed to blockade of the alpha 2-adrenoceptors involved in autoinhibitory feedback mechanism at nerve terminals, rather than to blockade of neuronal reuptake of noradrenaline. This effect on noradrenergic transmission in the central nervous system could explain the antidepressant actions of mianserin in accordance with the hypothesis of Schildkraut.

Animals↗
PubMed1984

Effect of antiorthostatic suspension on interferon-alpha/beta production by the mouse.

Mice were suspended in a model that simulates weightlessness that occurs during prolonged space flight. After 1 and 2 weeks of suspension in an antiorthostatic (head-down tilt) position, the mice were challenged with polyriboinosinic-polyribocytidylic acid to induce interferon-alpha/beta. Interferon production was severely reduced in mice that had been suspended. When mice were allowed to recover in cages for a week following removal from suspension, they recovered their full interferon-production capacity. Mice suspended in an orthostatic (horizontal) position did not have their interferon production capabilities affected, which indicates that stress per se was not a major component in the effects of antiorthostatic suspension on interferon induction.

Animals↗
PubMed1984

Deaths in a general practice.

The practice records were an inadequate source of information except when the certificate of death had been issued by the practice or a hospital report had been received. Autopsies were done only for deaths reported to the coroner and for some which occurred in public hospitals; in most cases the cause of death recorded by the doctor could not be verified. The lack of accurate information recorded about the cause of death in a patient who did not die in a hospital suggests that the doctor's clinical interest dissipates once death has occurred. Notes about the death were found in some records of relatives of the deceased but were not sufficient to substantiate the suggestion that the doctor had other demands at the time in supporting the bereaved. It was not certain that every death in the practice population was known to the practice; this could be overcome by the use of a computer which could identify inactive records and thus enable further enquiry. Malignant disease was the most commonly recorded cause of death. It is possible that most of the 27 deaths of unknown cause were due to myocardial infarction (which would parallel the causes recorded for all Australia) because they were unexpected. Three quarters of those who died were older than 65 years. A doctor was in attendance at 63 per cent of all deaths in the practice; the major determinant of this involvement was the place of death.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1983

Face up to it.

Explore the source record for details and available documents.

Acute Disease↗
PubMed1982

Nonconvulsive epileptiform activity appearing as ataxia.

Ataxia may be the result of otherwise silent epileptiform activity. We studied three patients, between 3 and 5 years of age, whose initial complaint was unsteadiness of gait. Each one of the patients had an epileptiform EEG with bursts of slow spike and wave activity. Each had normal results of diagnostic studies for other causes of ataxia. Specifically, none had anticonvulsant drug levels in the toxic range. Modification of the anticonvulsant regimen resulted in dramatic clinical and EEG improvement. Nonconvulsive epileptiform activity has been called pseudoataxia in the scant literature on this subject. This process should be considered in the evaluation of ataxia in children.

Adolescent↗
PubMed1981

Evaluation of platelet kinetics following porcine and mechanical valve replacement.

Because thromboembolic pathogenesis in mechanical prosthetic valves (MP) might involve selective MP platelet consumption with consequent reduced platelet survival, it has been suggested that lowered platelet half-life (T 1/2) detection provides identification of postoperative thrombotic risk. Porcine heterografts (PH) possess less thromboembolic hazards than MP; thus, comparative evaluation of PH versus MP platelet T 1/2 is germane to the test's thrombotic predictive value, yet platelet kinetics in PH require elucidation. Accordingly, 51chromium platelet T 1/2 was determined in 16 patients with substituted valves (10 PH and 6 MP). Average platelet T 1/2 in PH (2.9 +/- 0.6 d) was similar (p greater than 0.05) to MP (3.2 +/- 0.6 d), and both were considerably lower (p less than 0.05) than platelet T 1/2 in normal subjects (NL, 5.1 +/- 0.5 d). Furthermore, platelet T 1/2 was below the lowest NL platelet T 1/2 (4.0 d) in seven PH and three MP patients. Thus, frequency and extent of decreased platelet survival in PH are common and equal to MP. These results indicate that platelet half-life does not afford thromboembolic predictability in patients with mechanical valves and, instead, favors prosthetic-induced physical trauma causing abnormal platelet survival.

Adult↗
PubMed1981

Trends in the radiological study of pituitary adenoma.

The time and place for the use of plain films of the skull, arteriography and venography, CT with and without contrast enhancement, and metrizamide cisternography as a replacement for air encephalography, for the diagnosis of the various kinds of pituitary adenomas is discussed in conjunction with a report of the experience with eight pituitary adenomas.

Adenoma↗
PubMed1979

Gastrointestinal mucormycosis.

Mucormycosis is an acutely malignant fungal disease causing local thrombosis and infarction. Gastrointestinal infection most commonly occurs in diabetics or in the immunologically compromised. This case demonstrates the radiological appearances of the gastrointestinal lesion and prolonged survival with amphotericin-B therapy.

Adult↗
PubMed1978

Spectral response of the human eye.

A thermal activation energy of 1.5 eV for the activation of rhodopsin is needed to reduce the rate of thermal activations below the rate of optical activation at the luminance of the absolute threshold. The thermal energy of 1.5 eV is not inconsistent with the optical threshold energy of about 1.8 eV.

Humans↗
PubMed1975

[Diurnal variation of glucose tolerance and insulin secretion in man (author's transl)].

The present investigation was designed to determine whether the circadian rhythm of glucose utilization is based on a quantitatively different release of insulin and/or on changing secretory dynamics of the hormone. 22 healthy men received three oral glucose tolerance tests in the morning, afternoon and evening of the same day. The blood sugar levels in the afternoon and evening tests were significantly higher than those found in the morning tests. Also the plasma insulin response was higher in the afternoon than in the evening, but it showed a delayed rise and late peak response. In the evening the normal subjects responded as mild diabetics.

Adolescent↗