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Biomedical subjects

A Roszak

Publications and source records attributed to A Roszak.

17 recordsLinked to original sources
PubMed2002

[Analysis of epidemiologic risk factors for endometrial cancer].

UNLABELLED: The aim of this study was an analyse of several risk factors for women with endometrial cancer and their influence on overall survival. MATERIALS AND METHODS: A retrospective analysis covered 160 women treated with the primary surgery and adjuvant radiotherapy because of endometrial cancer. Age, lifestyle, age of menarche and menopause, parity, body size, hypertension and diabetes mellitus were determined. RESULTS: The 5-year survival rate were: 87% for the women younger then 60 and 70% for the older ones (p = 0.0026), 81% for the city women and 73% for the country women (p = 0.2034), 91% for the educated women and 70% for the women with elementary education (p = 0.0102), 85% for 1-2 x parous women and 65% for nulliparous (p = 0.0433), 79% for women without miscarriage and 63% for women with 2 or more miscarriages (p = 0.3265), 82% for women with menarche above age of 15 and 66% with menarche under age of 13 (p = 0.1989), 82% for women without obesity, diabetes, hypertension and 72% for women with hypertension, 64% with obesity, 50% for women with all analysed diseases (p = 0.0104). CONCLUSION: An analyse show that age, lifestyle, parity, body size and hypertension modify the overall survival of women with endometrial cancer.

Adult↗
PubMed2000

Estimation of neovascularisation in hyperplasia and carcinoma of endometrium using a "power" angio-Doppler technique.

The aim of this study was to estimate neovascularisation in hyperplasia and carcinoma of the endometrium using a "power" angio-Doppler technique. One hundred and eighty-two postmenopausal patients with irregular bleeding from the sexual organs were investigated. Age of the patients ranged between 46 and 78 years. No neovascularisation in a control group of women with normal histopathological results of the endometrium was observed. The sensitivity of this method with reference to the diagnosis of hyperplasia and cancer of the endometrium was 12.2% and 81.2%, respectively. The specificity and positive prediction values were equal to 100% each in both pathologies. The values of the analysed flow indices in the neovascular arteries in endometrial cancer were significantly lower (p<0.05) (properly PI-0.92+/-0.12; RI-0.46+/-0.08) in comparison to the corresponding values in hyperplasia of the endometrium (PI-1.38+/-0.28 and RI-0.66+/-0.18). In conclusion, using a "power" angio-Doppler technique irregular vascularity of the endometrium in a group of patients with hyperplasia was observed in 12.2% of all patients and in 81.2% of those with cancer of the endometrium. The analysis of the values of the blood flow qualitative parameters in the neovascularisation areas in the endometrium at the significance level of PI < or = 1.0; RI < or = 0.5 and TAMV > 18.0 cm can help determine the essential element in the differential diagnosis of benign and malicious lesions. Transvaginal ultrasonography with a "power" angio-Doppler technique can be a valuable diagnostic method in hyperplasia and cancer of the endometrium, especially useful in the early stages of these pathologies.

Adenocarcinoma↗
PubMed1997

[Malignant vulvar melanoma].

Vulvar malignant melanoma is a rare neoplasm with mostly poor prognosis. As compared with malignant melanoma of the skin vulvar melanoma infiltrates early deep into tissues and into abundant lymph and blood vascularisation. Epidemiology, clinical and histopathological data of primary vulvar melanoma are presented. Currently used methods of treatment are analysed. According to many authors the radical vulvar excision with bilateral lymphangiectomy in all stages of melanoma is a treatment of choice. Due to small population of patients with vulvar melanoma the randomized trials comparing different methods of treatment are not existing. Vulvar melanoma remains controversial medical problem with poor prognosis.

Female↗
PubMed1997

[A case of metastatic malignant melanoma of the vagina with a background of primary vaginal melanoma--clinical case].

Primary vaginal malignant melanoma is an uncommon disease with poor prognosis. As compared with malignant melanoma of the skin, vaginal melanoma infiltrates early deep into tissues and in the abundant lymph and blood vascularisation. Epidemiology, clinical and histopathological data and treatment methods of primary and metastatic vaginal melanoma are discussed. A case of 53 years old women with malignant melanoma of the skin with metastasis to vagina treated in Wielkopolska Center of Oncology is presented. According to the literature aggressive surgical therapy can improve greatly the outlook for patients with vaginal melanoma.

Female↗
PubMed1996

[Role of second-look surgery in treatment of ovarian neoplasms].

The operation second-look was carried out on 66 women with ovarian cancer without any clinical symptoms of disease. 14 of them (21.2%) showed persistent cancer, including 5-cancer in early stages. The level of CA 125 didn't exceed 35 U/ml in 60 women, and in 5 women persistent cancer wasn't detected during the second-look operation. Negative result of second-look operation doesn't inform about recovery because in 8 women out of 52 recurrence of cancer reported.

Adult↗
PubMed1996

Relation between infection with human papilloma viruses and expression of p21 and p53 oncoproteins in patients with cancer of the uterine cervix.

Infection with HPV type 16 was demonstrated in 54% of the cases and infection with HPV type 18 in 36.5% of the cases of uterine cervix carcinoma. Both types of viruses were present in 24.3% of the patients. P53 protein accumulation in cell nuclei was observed in 12.2% of the cases of uterine cervix carcinomas and the cases were mostly HPV negative while the cytoplasmic expression of p53 protein was present in 39% of the cases and was frequently accompanied by HPV infection. Presence of p21 protein was detected in 85.3% of the cases, independently of HPV infection or expression of p53 protein.

Female↗
PubMed1996

[Intracavitary brachytherapy method using after-loading for treatment of women with endometrial uterine neoplasm].

We would like to introduce intracavitary brachytherapy using double rod-shaped applicators. The women who are treated with this method are evaluated in III FIGO stage and the patients in stage I and II who could not undergo the operation. This method allows to distribute equally the dose in whole uterus, insertion of the applicators is not difficult. The brachytherapy treatment is well tolerated.

Adult↗
PubMed1996

[Evaluation of SCC antigen in patients with advanced cervix cancer treated with radiation].

The TA-4 antigen was isolated and described in 1977 by Kato and Torigoe. The antigen called SCC-squamous cell carcinoma is subfraction TA-4 isolated of liver metastases from cervix uteri. The cut-off limits for SCC-antigen is counted as 1.5-2.5 ng/ml. The level of SCC-antigen was determined in the serum of 41 women with advanced cervix uteri cancer-IIIB and IV FIGO stage. The value of SCC-antigen was evaluated twice: before and after the treatment. The increasing of SCC-level was observed in the serum of 80% women. The conclusion are: There was the lowering of SCC-antigen value in patients after the irradiation. In cases of patients who still had high SCC-antigen level after the treatment and it exceeded 8 ng/ml., progression of cancer also was found. The progression of cancer after the treatment was found in women with pretreatment level of SCC-antigen higher than 30 ng/ml.

Adult↗
PubMed1995

[Evaluation of blood flow in uterine arteries in patients with cancer of the cervix uteri using transvaginal color doppler ultrasonography].

The purpose of the study was to estimate blood flow in uterine arteries in patients with uterus cervix invasive carcinoma. In the study the colour Doppler ultrasonography was used. It was found out that in the group of patients with uterus cervix carcinoma pulsation index (PI)--1.82 +/- 1.44 as well as resistance index (RI)--0.72 +/- 0.12 are statistically significantly lower than adequate indices in the control group (PI)--3.36 +/- 1.04 and (RI)--0.81 +/- 0.17 (p < 0.05).

Adult↗
PubMed1994

[Factors influencing the outcome of radiotherapy for endometrial tumor of the uterus].

Assessment of the influence of staging, age of women, type and grading of carcinoma of endometrium, uterus size as well as radiotherapeutic methods on 5-year survival was undertaken. The study was performed on 227 patients with Ist, IInd, IIIrd stage of carcinoma in whom only radiotherapy was applied. All of the mentioned factor have prognostic value, but the most important is staging and grading. Brachytherapy is also important prognostic factor.

Brachytherapy↗
PubMed1994

[Prognostic survival of women after surgery for endometrial cancer].

The influence a few factors on prognosis on 5-th year survival has been estimated in 367 patients with endometrial cancer with stage I, II and III disease which underwent surgery and radiotherapy. The stage is the most important and competent authority indicators of prognosis on 5-th year survival, among prognostic variables for endometrial carcinoma the most important have been identified as: 1) histologic type, 2) grading, 3) depth of myometrial invasion. The 5 year survival appeared correlated with the age of patients survival of patients younger than 59 years of age was higher and statistically significant.

Age Factors↗