Biomedical subjects

A Rougereau

Publications and source records attributed to A Rougereau.

At least 19 recordsLinked to original sources

PubMed1998

[Superficial cancer of the stomach in the area of Calvados from 1978 to 1990. Epidemiology and prognostic factors].

AIMS OF THE STUDY: The 5-year survival rate of gastric cancer is less than 20% in cancer registries. The prognosis of early gastric cancer is much better but this diagnosis is rare in Europe. The aim of the study was to evaluate the prognosis and trends in the incidence of early gastric cancer in the area of Calvados (France) during a 13-year period. METHODS: Between 1978 and 1990 the Digestive Cancer Registry of Calvados recorded 1,160 new cases of gastric cancer. The diagnosis of early gastric cancer was defined according to the Japanese Gastroenterological Society criteria. Prognostic factors were determined with univariate and multivariate analysis. RESULTS: One hundred patients had early gastric cancer (8.6%). This rate did not change significantly during the period. The mean age was 64.2 +/- 1.5 in males and 64.8 +/- 2.2 in females and 39% of patients were older than 70. A precancerous condition was present in 56% of cases on the surgical specimen. A total gastrectomy was performed in 23% of cases and a subtotal gastrectomy in 72% of cases. The postoperative mortality was 5% and the 5-year relative survival was 86.8% +/- 4.6. Univariate and multivariate analysis found a better prognosis in patients younger than 75 or in patients with a superficial or excavated gross appearance compared with those older than 75 or with a protruded type. Lymph node metastasis, depth of invasion, size of the tumor and histologic differentiation did not influence significantly the outcome. CONCLUSION: According to the data of the Cancer Registry of Calvados the proportion of Early Gastric Cancer was low and did not change between 1978 and 1990. The prognosis of EGC is good, mainly altered in elderly and in cases with a protruded type.

Adult↗

PubMed1997

[Epidemiology of hepatocellular carcinoma in the department of Calvados].

OBJECTIVES: The aim of this study was to determine the epidemiological characteristics of hepatocellular carcinoma in a non-selected population. METHODS: Between 1984 and 1990, all cases of hepatocellular carcinoma were registered at the Registry of Digestive Tumors of Calvados. Standardized incidence rates were calculated for males and females. Prognostic factors were determined by the Cox multivariate method. RESULTS: 213 patients with hepatocellular carcinoma were registered. Standardized incidence rates were 7.5/100,000 in men and 0.4/100,000 in women. Sex-ratio was 18.3. Mean age was 66.4 years; hepatocellular carcinoma was uncommon (3%) before the age of 50. Cirrhosis was associated in 85.9% of patients. The cause of cirrhosis was known in 150 cases: alcoholic: 73.3%, cryptogenetic: 8.7%, viral B or C: 7.3%, alcoholic and viral B or C: 5.3%, and genetic hemochromatosis: 4.7%. The overall survival rate in 203 patients was 21%, 8% and 3% at 1 year, 3 years and 5 years, respectively. The multivariate study identified 4 prognostic factors: number of tumors < or = 2, lack of ascites, serum alpha-fetoprotein < or = 10 mg/mL, and hepatocellular carcinoma revealing a well-compensated liver disease until the time of diagnosis. CONCLUSION: The occurrence of hepatocellular carcinoma seems to be linked to cirrhosis, male sex, and age > 50, which could be used as the main selection criterias for the screening of hepatocellular carcinoma.

Adult↗

PubMed1995

[Epidemiology and prognosis of gastric carcinomas at the province of Calvados. A 10-year study].

OBJECTIVES: The aim of this study was to determine trends in incidence and survival for gastric cancer in the department of Calvados over a ten-year period. METHODS: Between 1978 and 1987, 999 patients with gastric cancer were registered by the Registry of digestive tumours of Calvados. Standardized incidence rates were calculated for males and females and for each site of the tumour in two consecutive 5-year periods: period I: 1978-1982; period II: 1983-1987. Then prognostic factors were determined with univariate and multivariate methods. RESULTS: Global incidence rates were 15.7/100,000 in men, and 6.7/100,000 in women. Incidence rates of antropyloric carcinomas significantly decreased in women (period I: 3.6/100,000, period II: 2.1/100,000; P < 0.01). The incidence rate of cancer of the cardia did not change in men (period I: 2.7/100,000, period II: 2.9/100,000; NS) nor in women (period I: 0.6/100,000, period II: 0.3/100,000; NS). The ratio of early gastric cancer was respectively 8% and 9.2% (NS). The frequency of "signet ring" cells carcinomas increased from 20% during period I, to 34% during period II (P < 0.05). Overall 5-year survival rate was 16%; it was 26.3% after resection, without significant change between the two periods (27% versus 24.4%). The multivariate study in gastric cancer after resection pointed out 5 prognostic factors: age over 75 years, invaded resection margins, lymph node involvement, metastases and parietal wall involvement. CONCLUSIONS: The results of this epidemiologic study in the department of Calvados indicate that a) the global prognosis of gastric cancer was poor and did not change over the 10 years of the study; b) incidence rates of antropyloric carcinomas slightly decreased in women; c) rates of early gastric cancers did not increase.

Adenocarcinoma↗

PubMed1993

[Cancer of the gallbladder. Epidemiology, diagnosis and prognostic factors].

Between 1978 and 1986, 77 cases of primary gallbladder carcinoma were recorded in the Calvados Digestive tumors Registry (covering a population of 589,559 inhabitants) among 125 extra-hepatic bile duct carcinomas. The crude incidence was 2.4/100,000 in females and 0.6 in males (sex-ratio = 3.8). Cholelithiasis was demonstrated in 81.3%. Gallbladder carcinoma was diagnosed correctly preoperatively in only 13.5%. Out of the 74 operated patients, there were only 6 mucosal or sub-mucosal carcinomas and liver involvement was present in 40%. Diagnosis was made post-operatively on the resected specimen in 13 patients (non reoperated) Operative mortality was 24%. The overall survival was 14.7% at one year, 4% at 5 years (median = 3 months). In multivariate analysis the prognostic factors were: curative resection (9 patients, 3-year survival: 55%), parietal extension, liver involvement. No significant trend in prognosis could be demonstrated during the study period.

Actuarial Analysis↗

PubMed1992

[Application of multifactorial statistical calculation searching for a correlation between fat soluble vitamins and cancer].

The aim of this work was to combine computer methodology applied to multi-factorial statistical calculations with liquid chromatography results on the analyses of serum levels of retinol, bêta-carotene and tocopherols in healthy subjects and in patients with various cancers associated with certain tumor markers. Our results show that the serum levels of the vitamins studied differed in cancer patients in comparison to healthy controls. These results also confirm published data showing that serum variations are generally not characteristic of a specific tumor localization, without indicating if these variations are a cause or an effect of tumor development. Computerized multifactorial analysis taking into account the levels of all vitamins and tumor markers chosen, however, enabled us to classify the different tumors in five groups: cancers of the nervous system, urogenital tract cancers, laryngo-pulmonary cancers and two groups of digestive system cancers. This new approach may lead to the constitution of a data bank on the localization of tumors, as well as a reference system for all analyses of serum levels of vitamins associated with tumor markers.

Adult↗

PubMed1988

Serum levels of carcinomedin (1-keto-24-methyl-25-hydroxycholecalciferol) as an indicator of the progression of cancer. Preliminary results of a prospective study.

The serum levels of the cholesterol derivative 1-keto-24-methyl-25-hydroxycholecalciferol found in patients with cancer varies after surgical, chemical or radiotherapy treatments. The serum level associated with the vitamin profile has a predictive value for evaluating progress of the disease and therapeutic efficacy. The detection, identification and assay of a vitamin D3 derivative, 1-keto-24-methyl-25-hydroxycholecalciferol, named carcinomedin by us, in the serum of cancer patients was described in prior work. Also, the assay of carcinomedin, combined with those of serum levels of vitamin A, beta-carotene and alpha-tocopherol indicated a statistically significant correlation between these parameters and the localization of the primary neoplastic mass. In spite of the probable connection between carcinomedin and the presence of a neoplastic mass, several questions remain unanswered. In particular, it may be asked if the stage and progression of the tumor, surgical, chemotherapeutic or radiotherapeutic treatments may be related with any type of change in the serum levels of carcinomedin and fat soluble vitamins? To verify and respond to these questions, patients with various cancers (stomach, esophagus, breast, ovaries, uterus, etc.) were followed for three years. Clinical data were compared to analytical data supplied by assays of carcinomedin and the fat soluble vitamins.

Adult↗

PubMed1987

Fat soluble vitamins and cancer localization associated to an abnormal ketone derivative of D3 vitamin: carcinomedin.

Many investigations suggested relations between fat soluble vitamin levels in blood and incidence of cancer. These studies are concerning both therapeutical efficiency of vitamins intake, seric levels and cancer risk, and the supposed correlation between blood fat soluble vitamin levels and the cancer localization. The purpose of the present study was to investigate whether the alterations of fat soluble vitamin levels (A-vitamin, beta-carotene and alpha-tocopherol) were correlated not only to carcinogenic processes but also to the localizations of their developments. In a former article, we have found that an abnormal ketone derivative of D3 vitamin (1-keto-24-methyl-25-hydroxycholecalciferol) or carcinomedin was present in the serum of all cancer patients and absent in that of healthy control subjects. Serum levels of the four above substances were determined in 1068 subjects suffering from differently localized cancers and in 880 healthy subjects. A statistical multidimensional analysis of data led a separate five groups of cancer types (p less than 0.001). Within each group alterations of vitamin spectra, compared to controls, were identical; between groups they were significantly different. These groups were: anal and intestinal cancer; pancreatic, hepatic, oesophageal and gastric cancer; laryngeal and lung cancer; uro-genital and breast cancer; brain cancer. All these groups are statistically different from the reference one (p less than 0.001). This grouping roughly corresponds to the embryologic origin of affected organs. This suggests that carcinogenesis may alter fat soluble vitamin metabolism, specifically in various forms of cancer, or these alterations of vitamin metabolism are in some way involved in the carcinogenic process.

Adult↗

PubMed1987

Isolation from the serum of cancer patients and molecular structure determination of a ketone derivative of D3 vitamin.

In a previous article we have reported our finding of an unknown vitamin derivative in the serum of cancer patients and in rats transplanted by a malignant tumor. Analysis of this compound extracted from serum of cancer patients, was carried out by I.R., U.V., mass spectrography and nuclear magnetic resonance (N.M.R.) determination. This analysis led us to the conclusion that the compound was a ketone derivative of D3 vitamin: 1-ceto-24-methyl-25-hydroxycholecalciferol, provisionally designated D3C. Enzymatic pathways involved in the biosynthesis of this substance and its possible role in normal and pathological cell division are discussed.

Calcitriol↗

PubMed1987

Presence in human serum, associated with cancer, of an abnormal cholecalciferol derivative, the 1-ceto-24-methyl-25-hydroxycholecalciferol. Preliminary results of a prospective study.

Using new techniques for micro-determinations of blood fat soluble vitamin concentrations, this study from a large population of cancer patients compared to healthy controls led to the finding, extraction and isolation of an abnormal cholecalciferol derivative the 1-ceto-24-methyl-25-hydroxycholecalciferol. This factor was shown to be present in serum from cancer patients and absent in most normal controls. A double blind study has confirmed the diagnostic value of this new marker of cancer. In the same time, an animal study was performed. The abnormal cholecalciferol derivative, absent in intact rats, was found in the blood of rats transplanted by the Ehrlich carcinoma. The compound, extracted from serum of human cancer patients, injected to transplanted rats significantly decreased their survival time. Injected to untransplanted rats it induced hypocalcemia. The genesis and the possible role of this factor in cancer development are discussed.

Adult↗

PubMed1987

Retinol, beta-carotene and alpha-tocopherol status in a French population of healthy subjects.

Serum concentrations of retinol, beta-carotene and alpha-tocopherol have been determined in an homogeneous French population of healthy subjects. The mean values retinol: 148 +/- 35 UI per deciliter; beta-carotene: 32 +/- 10 microgrammes per deciliter; alpha-tocopherol: 1 +/- 0.2 mg per deciliter and the frequency distribution of values do not dedicate the presence of nutritional deficiencies in such a population. However the 5% lowest and highest (and beyond) levels are taken into consideration in their possible correlation with other pathological states.

Adult↗

PubMed1982

Ferritin and iron status in Senegalese women.

Ferritin, iron status, and hematological parameters--Hb, hematocrit--were determined in 172 mature women at screening visits in first aid medical care units located in Senegal. Of the subjects 36.6, 39.5, 34.9% had Hb, hematocrit, and ferritin levels below accepted norms (i.e., Hb less than 11 g/dl, hematocrit less than 33%, serum ferritin less than 10 ng/ml). Serum iron level was normal (greater than 50 micrograms/dl) in 94.2% of the subjects, but 48.3% had marginal levels (51 to 100 micrograms/dl). The distribution curves of Hb level in the population indicates that about 58% of the women had Hb less than 12 g/dl. Furthermore, the very low serum ferritin levels (less than 20 ng/ml) encountered in 75.6% of subjects, demonstrate the small size of their iron stores. This precarious iron balance indicates that these women are at a high risk of nutritional anemia. Numerous factors such as pregnancy or parasitical infestation can dramatically modify this iron balance and increase the prevalence of anemia in this population.

Adult↗

PubMed1981