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Biomedical subjects

A Roussanne

Publications and source records attributed to A Roussanne.

4 recordsLinked to original sources

[Prescribing and performing autologous blood transfusion: experience at a University Medical Center].

Prescription and carrying out of autologous blood transfusion in a university hospital during a whole year (1992) were investigated. 554 patients were involved. 88% of them gave at least one blood unit. Three surgical groups are specified: cardiac surgery with bypass (95 patients), orthopaedic procedures with knee or hip replacement or spine surgery (276 patients) and other types of surgery (117 patients). Prescriptions of blood donation before cardiac surgery were not carried out (by the transfusion centre) twice more often than in the other groups. This is why autologous blood taking is now effected in the anaesthetic unit. 88.9% (n = 434) of all patients did not receive homologous blood (90% in the orthopaedic group, 84% in the cardiac group). 25% of the collected units were not transfused. This figure is only 8% for the cardiac patients. An efficiency index is suggested taking in account the transfusion of autologous blood units and the need of homologous transfusion: % autologous used units x % procedures realized without homologous blood. The good rate to achieve could be 70%. In aorto-coronary bypass surgery when no autologous blood was collected preoperatively, 57.5% patients received homologous blood vs 16% when at least one unit was predeposited. A short review of literature shows an increasing place of predeposited autotransfusion, with some limits in orthopaedic surgery where a combination of autologous blood donation and other erythrocytes saving methods appears to give the best results. Erythropoietin, critical haemoglobine concentration threshold, autologous transfusion in cancer patients still need further studies.

Academic Medical Centers↗

[Hyperthyroidism and mitral valve prolapse: comparative two-dimensional echocardiography study of a hyperthyroid and a control population totalling 104 patients].

Recent studies seem to demonstrate a higher incidence of mitral valve prolapse in hyperthyroid patients. A complete cardiological check-up including 2D echocardiography was performed in 52 hyperthyroid patients and 52 control subjects. In the hyperthyroid population, mitral valve prolapse was diagnosed 3 times, 5,8 p. 100 of cases. These 3 subjects were female; hyperthyroidism was nodular in 2 cases: Grave's disease was only present in 1 case. Hyperthyroidism was very active at the time of the echocardiographic study in those 3 patients. In the control group, mitral valve prolapse was observed in 4 cases (7.7 p. 100). These 4 patients were all female. The results of this study do not show a higher incidence of mitral valve prolapse in the hyperthyroid population than in the control group. Grave's disease was not more prevalent in hyperthyroid patients with mitral valve prolapse. On the other hand, there were significantly more female patients with MVP in both the hyperthyroid and control populations.

Echocardiography↗

[Prolonged hyperthyroidism and recurrent atrio-ventricular block].

The authors report the case of a patient with hyperthyroidism who had three episodes of grade 2 and 3 atrio-ventricular block over a 6-year period. After he recovered from hyperthyroidism, the atrio-ventricular conduction returned to normal and remained so throughout a 5-year follow-up. A grade 1 atrio-ventricular block is found in 6 to 8 p. 100 of hyperthyroid patients, but grade 2 and 3 blocks are rare in such patients. Case reports in which thyrotoxicosis alone seemed to be responsible for disorders of conduction are exceptional; frequently, other factors likely to induce such disorders were present. In 90 p. 100 of the cases hyperthyroidism was due to Graves' disease; it lasted for more than one year and thyrotoxicosis was often severe. These facts suggest the possibility of a thyrotoxic myocarditis and/or an autoimmune focal myocarditis. Although rare, atrio-ventricular block in hyperthyroid subjects is a possibility that warrants electrocardiographic monitoring, notably when negative dromotropic drugs are prescribed.

Adult↗