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A Routledge

Publications and source records attributed to A Routledge.

6 recordsLinked to original sources
PubMed2005

Recent advances in analytical construct resins.

The area of solid-phase synthesis has witnessed exponential growth in the last fifteen years, but difficulties associated with the monitoring and analysis of resin-bound reactions and products have been apparent due to a limited number of analytical methods available. With the substrate tethered to an insoluble support traditional chromatographic monitoring is only possible after cleavage. In order to address this 'analytical bottleneck' Geysen, in 1996 elaborated Merrifield's initial dual linker strategy by incorporating an encoding system between two in-line linkers. These analytical construct resins represented a new approach for both the quality control of solid-phase combinatorial libraries and for the development of new synthetic sequences on solid-support. This review will summarize the development and application of analytical construct resins focusing on recent applications of the technology.

Chemistry Techniques, Analytical↗
PubMed2000

Surface stability of granular systems under horizontal and vertical vibration: the applicability of a coefficient of friction

We investigate the conditions under which the surface of a granular pile becomes unstable to vibrations. Three stability boundaries are identified, which depend upon the relative phase of the driving forces and the angle of the prepared slope. The experimental findings can be interpreted within the context of a Coulomb friction model and used to define an effective coefficient of friction. For up-hill motion we find that the coefficient of friction depends strongly on the slope angle and that, in general, it requires less vibration to transport grains uphill than would be otherwise expected.

Journal Article↗
PubMed1996

The glycosidic precursor of (Z)-5-ethylidene-2(5H)-furanone in Halocarpus biformis juvenile foliage.

A new glycosidic lactone, (5R,6R)-5-(1-hydroxyethyl)-2(5H)-furanone beta-D-glucopyranoside, has been identified as the principal precursor of (Z)-5-ethylidene-2(5H)-furanone in juvenile foliage of the New Zealand tree Halocarpus biformis. Three related lactone glycosides were isolated in smaller amounts, together with the known phenolic glycosides pyroside, arbutin and picein. The principal lactone glycoside underwent facile elimination of glucose, in neutral or basic conditions, to yield (Z)-5-ethylidene-2(5H)-furanone and its E-isomer. This lactone glycoside was also detected in foliage of H. bidwillii and H. kirkii.

Animals↗
PubMedDate not supplied

Identification and estimation of cell types in mixed primary cell cultures of early and term human placenta.

Placental villi of early and term human placentae were dissociated with trypsin and mixed cell cultures were established. The different cell types were identified and estimated over a 14-day culture period using antibodies to keratin and vimentin filaments and their capacity to phagocytose yeast. The three main cell types were found to be epithelial-, macrophage- and fibroblast-like cells. The epithelial-like cells can be further divided into the multinucleated and the small- and medium-sized round cells, and these are most likely to be derived from the trophoblast. The cellular composition of cultures were different for early and term placentae and also varied characteristically over the 14-day cultures period.

Antibodies↗