The authors report a case of fatal pancytopenia associated with sulfamethoxazole-trimethoprim therapy in a patient with folic acid deficiency. The mechanism is a matter of speculation, but the most attractive view is that the inhibiting effect of trimethoprim on dehydrofolate reductase can involve pancytopenia in patients with folic acid deficiency.

Drug Combinations↗

PubMed1978

[Acute thrombopenia during treatment with sulfamethoxazole-trimethoprim].

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Acute Disease↗

PubMed1977

[Anuria with hyperuricemia revealing acute leukemia. Treatment with urate oxidase].

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Aged↗

PubMed1976

Hematologic toxicity of thiophenicol.

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Anemia, Aplastic↗

PubMed1976

[Large non-secreting islet cell adenomas. Review of the literature].

The authors report a case of benign non secretory islet cell tumour. Ten other cases of this type were found in the literature. These non-functional tumours évolve without symptoms and are rarely diagnosed in the presence of an abdominal mass. They are usually discovered at autopsy. Clinical examination and further investigation do not always demonstrate the pancreatic origin of the tumour observed. Treatment is surgical consisting of removal of the tumour. Pathological examination leads to the diagnosis of non-secretory islet cell tumour which is usually benign; only the course can confirm this.

Adenoma, Islet Cell↗