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Biomedical subjects

A Rubio Suárez

Publications and source records attributed to A Rubio Suárez.

10 recordsLinked to original sources
PubMed2003

[Induction chemotherapy using vinorelbine, cisplatin, and UFT in advanced pharyngeo-laryngeal carcinomas: results of a phase II study].

OBJECTIVE: To evaluate the results of an induction chemotherapy protocol with Vinorelbine, UFT and Cisplatin (UFTVP). METHODS: 93 patients with laryngo-pharyngeal squamous cell carcinoma in stage III or IV were prospectively entered into a protocol to receive four cycles of UFTVP. Responders followed definitive radiation therapy. Nonresponders underwent conventional surgery with postoperative radiation. RESULTS: Following chemotherapy nodal response (complete in 28% and partial in 33%) was less than that the primary site (complete in 60% and partial in 30%), p = 0.002. With a median follow-up of 62 months, the Kaplan-Meier 5-year survival was 45%. Successful larynx preservation was achieved in 50% of patients with laryngeal cancer and in 29% of patients with hypopharyngeal cancer. Lymph node metastases and pharyngeal localization were found to be significant negative factors with regards to survival. CONCLUSIONS: UFTVP is an active regime of chemotherapy in advanced squamous cell carcinoma of the pharynx and larynx. Results differ according to the localization, having significantly better rates of survival and organ preservation in the laryngeal cancers that in those of the pharynx.

Adult↗
PubMed2001

[Early diagnosis of nasopharyngeal carcinoma].

For making an early diagnosis of nasopharyngeal carcinoma it is fundamental to fulfill three requirements. First a high suspicion index based in the knowledge of symptoms and signs of the malady. Secondly it is necessary the routinely use in the consulting room of a nasopharyngoscope. An in third place is to make, in doubtful cases, an enlarged biopsy under endoscopic control and local anesthesia.

Aged↗
PubMed1999

[Diagnosis and treatment of cervical esophageal perforation in adults].

OBJECTIVE: To evaluate the management of cervical esophageal perforation in adult patients. MATERIAL AND METHODS: A retrospective clinical review was made of all cervical esophageal perforations diagnosed in adult patients in the ear, nose and throat department of Marqués de Valdecilla Hospital (Santander, Spain) between January 1989 and December 1996. Age, sex, symptoms, cause of perforation, time to diagnosis, diagnostic studies, treatment, and evolution were obtained from the clinical records. RESULTS: Eleven patients with perforation of the cervical esophagus, age range 38 to 84 years, were seen in the study period. In 8 cases, perforation was caused by a foreign body and 3 cases were iatrogenic (after rigid esophagoscopy). The most frequent symptoms of presentation were cervical pain and odinophagia. Nine patients were treated with broad-spectrum intravenous antibiotic therapy and no oral feeding. Two patients were treated surgically. There were no complications or need for further surgery in any case. CONCLUSIONS: Small perforations of the cervical esophagus in adult patients produced by foreign body impaction or rigid esophagoscopy can be managed by observation, restricted oral intake, and intravenous antibiotics. Neck exploration should be reserved for patients with signs and symptoms of cervical or mediastinal infection.

Adult↗
PubMed1998

[Overexpression of p53 protein in epidermoid carcinoma of the pyriform sinus].

Mutation of the p53 protein may be the commonest genetic event in the development of malignant neoplasms in humans. We analyzed the immunohistological expression of p53 in tissue sections from 51 patients with squamous cell carcinoma of the pyriform sinus who were treated with surgery and postoperative radiotherapy. Overexpression of p53 was found in 37 (72.5%) tumors. No correlation was found between p53 overexpression and clinical and histopathological parameters. Recurrence and overall survival did not differ between p53-positive and p53-negative cases.

Adult↗
PubMed1996

Mucormycosis of the sphenoid sinus in an otherwise healthy patient. Case report and literature review.

Paranasal and rhinocerebral mucormycosis refers to uncommon opportunistic fungal infections, reported to occur especially in association with diabetic acidosis (the most common), immunosuppressive therapy, malignancy, or other chronic debilitating disorders. However, patients who have no underlying disease have occasionally been affected. According to the literature reviewed, only 13 well-documented cases without any predisposing factor have been previously reported. We describe a unique case of sphenoidal mucormycosis in an otherwise healthy individual, and the first patient to present with headache as the only symptom. We emphasize the importance of a high index of suspicion for early diagnosis and prompt management.

Humans↗
PubMedDate not supplied

[Carcinoma of the nasopharynx in Cantabria].

OBJECTIVE: To describe the incidence and main clinicopathologic features of nasopharyngeal carcinoma (NPC) in Cantabria, Spain, and compare these data with reports published in Spain. MATERIAL AND METHODS: The medical records of all patients with the diagnosis of NPC seen in our division in the last 20 years were reviewed. RESULTS: Eighty-two patients ranging in age from 11 to 84 years were diagnosed as NPC. Sixty-five (79.3%) were males. The initial physical examination of the nasopharynx was normal in 7% of patients. The most frequent presenting complaint was the presence of a neck mass in 47% of cases. Forty percent of patients had cranial nerve involvement and 4.9% had distant metastases at the time of diagnosis. The lateral wall was the most frequent tumor location. The histopathological type was undifferentiated carcinoma in 71% of cases. Most patients had advanced-stage disease at the first visit. CONCLUSIONS: The incidence of NPC in Cantabria is 0.8 per 100.000 inhabitants per year. The highest incidence rate occurred in persons 50 to 70 years-old. Males predominated with a male: female ratio of 4:1. Undifferentiated carcinoma was the most frequent histological type. Our findings were similar to those reported in other series of patients with NPC in Spain.

Aged↗
PubMedDate not supplied

[Simultaneous bilateral facial paralysis].

Simultaneous bilateral facial paralysis (SBFP) is very rare, but it can present itself as the first complaint in a wide spectrum of diseases and a comprehensive evaluation must be completed. Bilateral Bell's Palsy can be diagnosed only when all other possible causes have been excluded. The prognosis and treatment for SBFP is dependent upon the underlying etiology. We present four cases of SBFP seen in our department which were finally diagnosed as leukemic infiltration, sarcoidosis, Bell's Palsy and demyelinating polyneuropathy (probably Guillain-Barré syndrome). The most important etiologies of the SBFP and the management of this entity are discussed.

Adult↗
PubMedDate not supplied

[Verrucous carcinoma of the larynx].

The present work shows a retrospective study of 11 cases of verrucous carcinoma of the larynx from data collected at Marqués de Valdecilla Hospital for ten years. All patients were males. Glottis was the most common site involved (10 cases). Eight patients were treated with partial surgery and in two cases total laryngectomy was performed. One patient refused treatment. Five-year survival rates were 100% in the ten patients treated. Verrucous carcinoma of the larynx is a well differentiated variant of squamous cell carcinoma. Surgical treatment is necessary for the primary lesion without neck dissection. Radiotherapy is not indicated because the possibility of anaplastic transformation. Prognosis is excellent after surgical treatment.

Adult↗
PubMedDate not supplied

[Sphenoidal metastasis of laryngeal carcinoma].

Metastatic tumors to the nose and paranasal sinuses are very uncommon and metastases to the sphenoid sinus are exceedingly rare. The most common tumor sites from which sphenoid metastases arise are the kidney and the lung. Distant metastases from laryngeal carcinoma are rare, the most common sites being the lungs, skeletal system, and liver. We report a patient with a supraglottic laryngeal carcinoma who had metastases to the sphenoid sinus. The management of this entity is described and cases reported in the literature are reviewed.

Adult↗