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Biomedical subjects

A S BURGEN

Publications and source records attributed to A S BURGEN.

At least 19 recordsLinked to original sources
PubMed1963

INTESTINAL ABSORPTION OF TRITUM-LABELLED FOLIC ACID IN IDIOPATHIC STEATORRHEA: EFFECT OF A GLUTENFREE DIET.

The intestinal absorption of folic acid in patients with idiopathic steatorrhea was studied by the oral administration of tritium-labelled folic acid in a dosage of 15 mug./kg. Results were expressed as a percentage of the orally administered folic acid radioactivity excreted in the urine over 24 hours. The mean excretion of radioactivity in 38 normal subjects was 48.2 +/- 16.6% (mean +/- SD), whereas eight patients with untreated idiopathic steatorrhea excreted only 16.7 +/- 3.4% (mean +/- SE).The ability of the gluten-free diet to correct this absorptive defect was demonstrated by the finding of normal values in 11 patients in complete clinical remission for periods exceeding six months after institution of the diet. Serial studies in individual patients indicated that a significant improvement was obtainable in as short a period as two weeks following exclusion of gluten from the diet.

Administration, Oral↗
PubMed1962

Absorption of folic acid from the small intestine of the rat.

The absorption of folic acid from segments of the small intestine of the rat has been measured in situ with tritium-labelled folic acid. The fraction absorbed was independent of concentration below 10(-6) M but was depressed to half at 4x10(-5) M. Direct measurements of fluxes showed that the mucosal --> serosal flux was about 14 times the serosal --> mucosal flux, and therefore that uptake of folic acid is an active process. In the ileum but not in the duodeno-jejunum, absorption was depressed by the presence of electrolyte. There was little difference in absorptive capacity between jejunum and ileum nor was there any significant change in animals suffering from a dietary deficiency of folic acid.

Animals↗