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Biomedical subjects

A S Boyd

Publications and source records attributed to A S Boyd.

90 records · Page 5Linked to original sources
PubMed1989

Lichen spinulosus: case report and overview.

Lichen spinulosus is a benign follicular eruption seen primarily in younger persons and is frequently classified among the follicular keratoses. Grouped patches of spinous papules are seen involving the elbows, knees, and buttocks. An atopic background is frequently present in these patients. We describe here a patient treated with multiple modalities over eleven years without appreciable benefit and whose condition showed significant clearing after his first visit to a dermatologist. An overview of this unusual disease process is presented.

Adult↗
PubMed1988

Scalp psoriasis.

Many people suffer from scalp psoriasis. While the cause of this condition is not known, there is effective treatment. With well-planned therapy and patient compliance, scalp lesions can be controlled. Useful agents include coal tar shampoos and preparations, keratolytics and topical corticosteroids. Systemic agents are almost never indicated for scalp psoriasis alone.

Adrenal Cortex Hormones↗
PubMed1988

Varicoceles and male infertility.

Approximately 15 percent of the postpubertal male population develops varicoceles, and one-third of men seen in fertility clinics have this lesion. Semen samples commonly show diminished sperm counts, decreased motility and immature cellular morphology. Treatment is usually surgical, although percutaneous methods are now available. Early diagnosis and treatment may prevent the testicular insult.

Adult↗
PubMed1988

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Anecdotes as Topic↗
PubMed1986

Biosynthesis of porphyrins and corrins. 1. 1H and 13C NMR spectra of (hydroxymethyl)bilane and uroporphyrinogens I and III.

High-field NMR spectroscopic methods have been applied to study the reactions catalyzed by porphobilinogen (PBG) deaminase and uroporphyrinogen III (uro'gen III) cosynthase, which are the enzymes responsible for the formation of the porphyrin macrocycle. The action of these enzymes in the conversion of PBG, [2,11-13C]PBG, and [3,5-13C]PBG to uro'gens I and III has been followed by 1H and 13C NMR, and assignments are presented. The principal intermediate that accumulated was the correspondingly labeled (hydroxymethyl)bilane (HMB), the assignments for which are also presented.

Ammonia-Lyases↗
PubMed1983

13C NMR studies of acetate metabolism during sporulation of Saccharomyces cerevisiae.

The sporulation of Saccharomyces cerevisiae in the presence of [2-13C]acetate was studied by 13C NMR spectroscopy. The fate of 13C label was analyzed in vivo and in cell extracts. During the first 4 hr of sporulation the major metabolite produced from [2-13C]acetate utilization was glutamate. From the labeling pattern observed it is concluded that both the tricarboxylic acid cycle and the glyoxylate cycle are operating. After about 4 hr trehalose is made. Comparison of the doublet/singlet ratios for C-1,1(1) and C-6,6(1) of trehalose shows a steady drop in the ratio of C-1, C-2-coupled species over trehalose labeled only at C-1 in the C-1, 2 segment of the molecule. The negative correlation of this ratio with that for the C-5, 6 segment indicates a cycling of glucose through the hexose monophosphate shunt. Subsequently fatty acid biosynthesis commences. Large amounts of saturated fatty acid were made. There were conspicuous differences observed in the metabolism of [2-13C]acetate between sporulating and vegetatively growing cells.

Acetates↗
PubMed1982

Intrasellar neural-adenohypophyseal choristoma. A morphological and immunocytochemical study.

A patient with mild acromegaly had recurrence of symptoms and signs of a chiasmal-area lesion seventeen years after radiation therapy for a presumed pituitary adenoma. A mass was found anterior to the pituitary gland. Abnormal tissue removed from the sphenoid sinus and sella turcica consisted of a predominantly ganglion-cell lesion. A few ganglion cells were immunoreactive for somatostatin. There were some small cysts lined by cells with immunostaining for glial fibrillary acidic protein, growth hormone or prolactin. Some cells with vacuoles and eosinophilic granules showed immunostaining for growth hormone, prolactin, ACTH, and beta-endorphin and, thus, appeared to be of adenohypophyseal origin. Cases of intrasellar ganglion-cell lesions have been reported, most of them associated with pituitary adenomas and acromegaly. The findings in this case are discussed in relation to the hypothesis that displaced, hypothalamic-type ganglion cells may produce a growth hormone-releasing factor that stimulates the development of a growth hormone-secreting pituitary adenoma. An alternative hypothesis is suggested that includes this concept, but also allows for the influence of non-neuronal cells on neuronal differentiation and for the possible influence of adenohypophyseal hormones on the replication of hypothalamic-type neurons in the lesion.

Adult↗
PubMed1981

Nervous system metastasis from carcinoma of the lung: three unusual cases.

Carcinoma of the lung, fairly common in middle aged men, may be silent and have its first manifestation as a metastatic lesion. In 25% to 35% of such cases the metastases are to the nervous system. Management is dependent upon many factors but satisfactory results can be obtained with proper screening. Three cases of nervous system metastases are presented-one occurred in an unusual site; one had an unusual clinical syndrome and one had prolonged latency.

Adenocarcinoma↗
PubMed1976

Angiotensin II and its heptapeptide (2-8), hexapeptide (3-8), and pentapeptide (4-8) metabolites in arterial and venous blood of man.

We made separate measurements of angiotensin II (A II) and of its immunoreactive metabolites (2-8 heptapeptide, 3-8 hexapeptide, and 4-8 pentapeptide) in arterial and venous plasma from subjects with widely different plasma levels of the peptides. A II and its three metabolites were extracted from blood, separated by paper chromatography, and measured by radioimmunoassay using an A II antiserum which had a 100% cross-reaction with each metabolite. In contrast to results of previous studies, A II was found to predominate in both arterial (60-100%) and venous (55-100%) blood. The biologically active 2-8 heptapeptide metabolite accounted for only 10% of the activity in arterial plasma. Radioimmunoassay of venous plasma extracts using an A II antiserum which had a low cross-reaction with the 3-8 hexapeptide and the 4-8 pentapeptide confirmed the results obtained using the antiserum which had a 100% cross-reaction with the metabolites. We conclude that radioimmunoassay methods for measuring A II in venous blood may be more accurate and relevant than has previously been recognized. The small difference between A II concentrations in arterial and venous plasma suggests further that there may be significant conversion of angiotensin I (A I) to A II in the limb vasculature.

Adult↗
PubMed1975

Pain suppression by peripheral nerve stimulation. Part I. Observations with transcutaneous stimuli.

A systematic, strict appraisal was made of 100 patients, after preliminary clinical trials suggested that some patients with pain could be helped by peripheral nerve stimulation. Transcutaneous stimulation of different nerve trunks was done with a special electrical stimulation device with various selected electrical parameters. More than half of the patients experienced some relief; in many, this effect was obtained by stimulating nerves distant from the area of referred pain. Pain relief lasted for varying periods after stimulation. The maximum benefit was noticed after certain specific parameters were reached for each patient. A few patients had response decay, gain or worsening. Results differ to some degree from previous reports. The results seem encouraging for the treatment of certain forms of intractable pain.

Adolescent↗
PubMed1975

Pain suppression by peripheral nerve stimulation. Part II. Observations with implanted devices.

Twenty-three patients underwent implantation of a stimulator system and were followed for 6-20 months. Twenty patients estimated between 50% and 100% pain relief. The effect was largely consistent and reproducible. Reduced drug intake and improved social performance were associated with subjective improvement. The surgical technique is given, complications are analyzed and parameters are discussed.

Adult↗
PubMedDate not supplied

How to submit a specimen for cutaneous pathology analysis. Using the '5 D's' to get the most from biopsies.

Evaluation of cutaneous biopsy specimens is greatly assisted by appropriate clinical information from the submitting physician. Without such data, it is difficult if not impossible to accurately interpret some histologic findings. As such, the more dermatopathologists know about the patient from whom a biopsy specimen is being obtained the more accurate their interpretation of the histologic findings may be. We have listed 5 categories of information all beginning with the letter D, which should be available to dermatopathologists as they evaluate a cutaneous biopsy specimen-description, demographics, duration, diameter, and diagnosis. Inclusion of this information with skin biopsy specimens will assist in their accurate and timely interpretation.

Humans↗