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Biomedical subjects

A S Dmitriev

Publications and source records attributed to A S Dmitriev.

At least 19 recordsLinked to original sources
PubMed1999

[Clinical and neurochemical features of depressive syndrome in neuroses and slowly progressive schizophrenia].

The examination was made of 78 patients (57 women, 21 men) with depression of neurotic level in slow progredient neurosis-like schizophrenia or neurosis. In all the cases of neuroses depressive syndrome correlated with relevant premorbid structure of the person. Meanwhile, such correlation was not clearly observed in schizophrenic patients. Complication of the clinical picture of the depression wasn't the same in cases of schizophrenia and neuroses, and resulted from productive symptomatics of different registers. The results of neurochemical studies evidence, that physiologic inactivation of serotonin, in terms of a removal of the active molecules from a zone of interaction with the receptors, was considerably increased in patients with neuroses as compared with schizophrenic patients. This suggests treatment of neurotic patients with the drugs, which inhibit serotonin reuptake selectively.

Adult↗
PubMed1996

[Forensic psychiatric expertise in brain tumors].

The patients with brain tumors are quite rare in forensic-psychiatric practice. The authors observed only 21 cases during 25 years (that is 0.05% from all the persons subjected to the forensic-psychiatric examination). The tumors were revealed in 11 patients during examination; 10 patients underwent forensic-psychiatric examination after operation for brain tumor. There were different mental disturbances of various degree in such patients: disorders of memory, emotional instability, impulsivity, disorders of consciousness, phenomena typical for epileptiform syndrome, and other disorders. 16 patients were characterised as irresponsible ones. The supervision of neurologist and psychiatrist was recommended in all cases.

Adult↗
PubMed1989

[Clinico-diagnostic criteria of protracted anxiety-related depression in manic-depressive psychosis and attacks of schizophrenia].

The study of premorbid period and factors capable of provocking the disease enabled the author to give the comparative clinical and psychopathological characterization of formation and course of prolonged anxious depressions in the framework of circular psychosis vs. schizophrenia. The predictors of these diseases prolongation are described. The present work allowed us to perform a differentiated approach to treatment of prolonged anxious depressions in patients with different disorders.

Adult↗
PubMed1987

[Electric reactive potentials to events with a positive and negative coloring in patients with protracted depression].

The authors measured electrical reactive potentials in the posterior associative and frontal areas, originating in response to winning or losing of the serve in tennis game shown on the video which served as a model of positive and negative emotional reactions. The studied potentials consisted of four waves: P300, N600, P800 and N1000. Healthy subjects experiencing positive emotions showed a more marked negative nature of the potentials in the left posterior associative zone while negative emotions were associated with the presence of predominantly negative potentials in the right frontal area. Patients with protracted depression presented a negative shift of potentials in both right posterior associative zone and left frontal area. The results obtained indicate that protracted depression is attended by impaired topography of the cortical processes associated with positive and negative emotions.

Adolescent↗
PubMedDate not supplied

[The role of trace excitatory processes in the formation of conditioned reflexes to time].

I. P. Pavlov's hypothesis on the role of trace excitation in conditioning to time was verified by mathematical methods proceeding from experimental data on elaborating in rabbits a motor alimentary conditioned reflex to a four-minute interval of time. A connection has been established between the experimental characteristics of formation of a reflex to time and some parameters of the presumed dynamics of trace excitation. The analysis helped to establish the shortest and longest intervals to which a reflex to time can be elaborated by the mechanism of trace reflex, as well as the optimal interval to which it is elaborated more easily. The experimental results so obtained are a significant corroboration to the correctness of the Pavlov hypothesis.

Animals↗
PubMedDate not supplied

[The role of glucocorticoids in the post-vibration changes in inhibition mediation in the brain structures].

Low-frequency vertical vibration for 2 hours together with three-fold increase of glucocorticoids is accompanied by the disruption of typical relationships of neuromediator processes (norepinephrine- and serotoninergic mediation) as well as the reduction of the intensity of choline trapping with glucocorticoid perception. Glucocorticoid-related conformation changes in plasma membranes and a drastic increase of the cAMP level provide plasticity of both nonspecific (hypothalamus, raphe bluish sites and nuclei) and specific (Deiters' nuclei) structures. The relationships of neuromediator processes in different CNS structures depend on the content of glucocorticoids. This should be taken into consideration when developing pathogenetically adequate methods for restoring the vestibular component of the motion sickness syndrome.

Animals↗
PubMedDate not supplied

[Effect of low-frequency whole-body vertical vibration on the serotoninergic system of the brain and spinal cord].

Rat experiments were performed to study variations in serotonin (5-HT) and its metabolite (5-hydroxy indole acetic acid) in different CNS compartments. Control animals were exposed to an acute vibration stress (10 Hz, 1 mm, 2 m/sec2, 15 min) and experimental animals to a prolonged (52-54 days) vibration test. Acute vibration led to 5-HT activation which was most significant in the hippocampus, diencephalon, cerebellum and in the sacrolumbar cord. Prolonged vibration caused an increase of 5-HT in the parietal cortex and its enhanced utilization in the striatum, diencephalon, pons and in the sacrolumbar cord. As compared to the controls, vibration produced a smaller accumulation of 5-HT in the hippocampus and a larger accumulation in the cerebellum, diencephalon, medulla oblongata and spinal cord. The paper discusses the role of regional changes in 5-HT metabolism and reactivity of serotoninergic structures in the mechanism of vibration-related somatosensory disorders.

Animals↗