Biomedical subjects
Publications and source records attributed to A S Fedoruk.
To evaluate ecologic load with nitrite-nitrate ions, the authors suggest determining the diurnal excretion and then excluding contribution of the endogenous compounds.
The authors analyze the data available in the literature on acute and chronic renal failure (ARF and CRF, respectively). The mechanisms of their development (common and distinctive) are pathogenetically assessed and the functional reserve of the kidneys is determined. The phasic character of development of renal failure (compensation, subcompensation and decompensation) is pathogenetically substantiated. ARF and CRF are shown to be two forms of renal failure development which have both pathogenetic and distinctive characteristics in its mechanisms.
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In experiments on non-inbred albino rats, intoxication was reproduced with 1% aqueous sodium nitrite solution, which was rated by the degree of hemic hypoxia (HH). The findings suggest that changes in renal functions (osmo-regulating, sodium-regulating) occur due to the development of mild HH, by increasing as hypoxia deteriorates. Decreased glomerular filtration and proteinuria, which are concomitantly detected, point to their mixed glomerulotubular pattern of renal lesion in nitrite intoxication.
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As shown in experiments on 54 noninbred white male rats, activation of lipid peroxidation in renal cortical substance contributes to impairment of renal function in acute hemic hypoxia. Administration of alpha-tocopherol promoted stimulation of renal protection: reduced the degree of proteinuria, sodium excretion, enhanced proximal reabsorption of osmotically active substances and sodium, glomerular filtration. This was accompanied with increased activity of superoxide dismutase and lowering of malonic dialdehyde concentration in renal cortical substance.