Biomedical subjects

A S Fenn

Publications and source records attributed to A S Fenn.

9 recordsLinked to original sources

PubMed1994

Do long-standing nodular goitres result in malignancies?

The records of 506 patients with histologically proven nodular goitre treated by thyroidectomy between January 1966 and July 1988 were reviewed. There were 21 patients with thyroid carcinoma in nodular goitre giving a proportion of 4.1%. There was an almost equal ratio of papillary to follicular carcinomas in the patients with malignancy occurring in a multinodular goitre (11 papillary to 9 follicular). One had an anaplastic lesion. These patients had swelling for a longer period, 9.11 years, as compared with an average of 5.48 years for those with only nodular goitre (P = < 0.01) using the Student's t-test. The male to female ratio in those with multinodular goitre alone was 1:10.8 while in those with carcinoma in multinodular goitre was 1:3.2. Comparing these two groups, the odds ratio of malignancy among males was 2.82 (95% confidence limits of the odds ratio being 1.4-5.5). This indicates that males with multinodular goitre had a significantly higher chance of developing a malignancy, Chi-squared value 5.74 (P < 0.05).

Adenocarcinoma, Follicular↗

PubMed1990

Typhoid ileal perforations: a retrospective study.

This report examines the characteristics of 124 patients with typhoid ileal perforation treated over a 17-year period ending in 1986. Three adverse prognostic determinants were identified: prolonged fever/perforation interval, prolonged perforation/operation interval and multiple perforations. Simple closure was performed in 74 patients with a mortality of 31.1%, and trimming of the ulcer with closure in 38 patients with a 7.9% mortality.

Adolescent↗

PubMed1983

Duodenal ulcer in South Indian children.

Twenty-nine children with duodenal ulcer received treatment during an 18 year period. Twenty-five were followed over a period that ranged from 3 to 18 years; 53.8 percent of the patients who received medical treatment either had recurrence or persistence of ulcer symptoms during adolescence or adulthood. Two patients with acute bleeding ulcers have remained well after vagotomy and drainage procedures. Pyloric stenosis was the most common indication for surgical intervention and in all such cases the patients underwent truncal vagotomy and drainage procedures and continue to live without any symptoms, except one in whom anastomotic ulcer due to incomplete vagotomy has developed.

Adolescent↗

PubMed1983

Primary peritonitis in children.

Thirty-one children with primary peritonitis were studied. Most of them had been healthy prior to the onset of peritonitis and only one had nephrotic syndrome. There were 27 girls and four boys. The predominant organism in girls was pneumococcus, and in boys staphylococcus. The causative organisms, identified in 27 children, were all Gram positive. Most of the children were between four and 10 years of age. The onset of their illness was sudden with fever, vomiting and abdominal pain. Since in recent years, primary pneumococcal peritonitis has been the commonest type of peritonitis in young girls, our earlier policy of routine laparotomy for peritonitis was given up and in girls aged between four and ten, an attempt at initial pre-operative diagnosis was made by Gram's staining of peritoneal aspirate or vaginal swab. If Gram positive peritonitis was diagnosed, early cases were treated with antibiotics alone and late cases with antibiotics and minilaparotomy for drainage of pus. There was one death. Morbidity and mortality were higher when the period without treatment exceeded one week. The contribution of pre-operative diagnosis by Gram's staining to the provision of optimum treatment is emphasized.

Child↗

PubMed1973