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Biomedical subjects

A S Fowle

Publications and source records attributed to A S Fowle.

33 records · Page 2Linked to original sources
PubMed1975

The dosage of co-trimoxazole in childhood.

Co-trimoxazole, a mixture of one part trimethoprim (TMP) and five parts of sulphamethoxazole (SMX) in fixed ratio was given to 48 children aged between one and 48 months twice daily for up to seven days. Twenty were relatively healthy and 28 were very ill. Dosage was based on age. Plasma concentrations of both drugs were measured just before a dose was due and some three hours later. They were in the efective but not toxic range and serve to justify the simple regimen which generated them.

Child, Preschool↗
PubMed1973

Biological availability of digoxin from Lanoxin produced in the United Kingdom.

Though established quality control standards were maintained, the bioavailability of digoxin from Lanoxin tablets produced in the United Kingdom fell in 1969, and was restored in 1972. After 1.5 mg doses of representative batches, tablets made between 1969 and 1972 produced mean values for area under the 50 hours plasma concentration/time curve of 36.6 ng/ml/hr and four-day urinary excretion of 340 mug, compared with respective values of 67.5 ng/ml/hr and 696 mug for recently produced tablets.After 0.5 mg doses of four recent independently produced batches of Lanoxin tablets no significant between-batch difference was found for area under the plasma concentration/time curve or cumulative urinary excretion.Absorption of digoxin from batches of Lanoxin manufactured since May 1972 is uniform and consistent. Content uniformity is an inadequate measure of tablet quality, and consistent digoxin bioavailability cannot be ensured by existing regulations.

Biopharmaceutics↗
PubMed1970

Acute brucellosis treated with trimethoprim and sulphamethoxazole.

Four patients with acute brucellosis are described, none of whom had any connexion with farming or milk industry, the source of infection being different in each case. The diagnosis was made by serological tests, and in three of the four cases was confirmed by positive cultures from bone marrow (one case) and liver biopsy (two cases). Treatment with the combination of trimethoprim/sulphamethoxazole was successful in three out of four cases, and in the fourth case failure may have been due to the development of trimethoprim resistance.

Acute Disease↗
PubMed1968

Trimethoprim.

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Anti-Bacterial Agents↗