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Biomedical subjects

A S Friedman

Publications and source records attributed to A S Friedman.

5 recordsLinked to original sources

Early childhood and maternal antecedents to drug use.

In a longitudinal study, the substance use/abuse histories were obtained on a community sample of 640, (mean age of 24.9 years) randomly selected from the 8,000 Philadelphia black subjects who had been studied comprehensively from birth to seven years of age in the National Collaborative Perinatal Project (NCPP). Among other conclusions, it is postulated from some of the many significant associations found between early life variables and substance use/abuse in early adulthood, that an infant is at risk who has the following combination of characteristics and family situation: outgoing, responsive, assertive or impulsive, or willful, and who is in an unfavorable family environment, with a mother who is generally negative toward the infant, has a larger number of small children and has had more fetal deaths, in a generally poor social environment.

Adult

Interaction of drug therapy with marital therapy in depressive patients.

Comparative effects of the antidepressant drug, amitriptyline hydrochloride, marital therapy, and the drug-psychotherapy interaction effects were studied in a 12-week course of treatment of outpatient depressives. Patients were assigned randomly to four treatment groups, in a 2 times 2 factorial design: (1) drug-marital therapy; (2) drug-minimal contact; (3) placebo-marital therapy; and (4) placebo-minimal contact. Both drug and marital therapy showed substantial beneficial advantages over their control conditions, but drug therapy was faster and generally superior in symptom relief and clinical improvement. Marital therapy was superior in family role task performance and perception of the marital relationship. For reducing hostility and enhancing the perception of the marital relationship, drug therapy had a better early effect, but marital therapy had superior effects by the end of treatment.

Adult