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Biomedical subjects

A S Krajewski

Publications and source records attributed to A S Krajewski.

57 records · Page 4Linked to original sources

Studies on blood lymphocytes of patients with nodular poorly differentiated lymphocytic lymphoma.

T and B lymphocytes were measured in pretreatment blood samples from patients wih nodular poorly differentiated lymphocytic lymphoma (NPDLL). There were significant differences in T cell values between control groups and patients with NPDLL. In 13 out of 20 cases of NPDLL blood lymphocytes showed abnormalities of immunoglobulin light chain expression and were considered to show an abnormal clonal expansion of B lymphocytes. The abnormal clone of B cells in the blood reflected that found in lymph nodes and could be detected in the absence of bone marrow involvement or blood lymphocytosis.

B-Lymphocytes↗

T-cell lymphoma in children and young adults: clinical, immunological and pathological features.

The clinical, pathological and immunological features in 5 cases of T-cell lymphoma without overt marrow involvement are described. Classification of this distinct sub-group of lymphoma on morphological and clinical criteria alone has been shown to be unreliable, and precise recognitionr equires additional information from cytochemical and immunological marker studies of peripheral blood and lymph nodes. Valuable information may also be obtained from analysis of pleural fluid. The accurate identification of this sub-group assumes new clinical relevance in the light of the considerable improvement in prognosis reported with treatment schedules that are effective in acute lymphoblastic leukaemia.

Adolescent↗