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Biomedical subjects

A S Markowitz

Publications and source records attributed to A S Markowitz.

At least 19 recordsLinked to original sources
PubMed1980

The role of glycoprotein carbohydrate in the immunological reactivity of antistreptococcal cell-membrane and antiglomerular basement-membrane antisera.

Rabbit antisera to "carbohydrate-rich" antigens prepared from group-A, type-12 streptococcal cell-membrane and human glomerular basement-membrane were found to react by an indirect fluorescent-antibody test with the glomerular basement membrane of adult human kidney. This activity was absent or diminished in neonatal tissue. Removal of the carbohydrate epitopes from the adult tissue by means of carbohydrases removed the immunological activity. Antisera against the "carbohydrate-rich" antigens showed immunological reactivities distinctly different from those against the parent native immunogens--streptococcal cell membrane or glomerular basement membrane--which proved to be directed towards the portein epitopes.

Antigen-Antibody Reactions↗
PubMed1975

Establishment of replicating long-term lines of rabbit macrophages and lymphocytes.

Macrophages (monocyte derived) and lymphocytes have been successfully cultured from rabbit peripheral blood so that replicating long-term cultures are maintained both in media and in the viable, frozen state. The macrophages are considered as such on the basis of phagocytic capabilities, gamma-globulin receptor sites as evidenced by rosette formation with sensitized red cells and disparate enzyme content from the lymphocytes.

Acid Phosphatase↗
PubMed1972

Chronic thyroiditis in the rabbit induced with homologous thyroid microsomes.

Rabbits immunized with freshly isolated homologous thyroid microsomes in complete Freund's adjuvant developed a severe chronic thyroiditis with the concomitant production of antimicrosomal antibodies. The antibody response was measured by indirect immunofluorescence and complement fixation, employing isolated microsomes as the antigen. Microsomes but not thyroglobulin absorbed out the immunologic activity of the rabbit serum.

Animals↗
PubMed1969

The bacterial induction of homograft sensitivity. 3. Effects of group A streptococcal membrane antisera.

Immunization of rabbits with Group A Type 12 streptococcal cell membranes has elicited serum antibodies which have the ability to cause rapid rejection of skin allografts in guinea pigs. Intradermal injection of such antisera has resulted in skin reactions characterized by prominent polymorphonuclear leukocyte infiltrates, similar to those noted in the Arthus reaction. The combined use of membrane antisera and epinephrine has resulted in hemorrhagic necrosis of the skin of guinea pigs. The ability of membrane antisera to exert these effects appears to be dependent upon the presence in the host tissues of antigen(s) shared by or cross-reacting with streptococcal membrane antigens. Such cross-reacting antigens may have a group distribution in the outbred guinea pig population. The results highlight the potential biological importance of antigens present in the Group A streptococcal membrane in the induction of altered tissue reactivity in the mammalian host.

Animals↗